Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kabamba B. Alexandre"'
Autor:
Oluwafemi Samuel Obisesan, Lesego L. Tshweu, Sipho Chauke, Kanyane Bridgett Malatji, Bathabile Ramalapa, Kabamba B. Alexandre, Hazel Tumelo Mufhandu
Publikováno v:
Nano Select, Vol 5, Iss 6, Pp n/a-n/a (2024)
Abstract The remarkable ability of the human immunodeficiency virus (HIV) to evade the host's immune system and conventional antiretroviral therapy, has posed significant challenges in achieving complete eradication of the virus in people living with
Externí odkaz:
https://doaj.org/article/ebbf7a40708049b8a18f6f4429573aeb
Autor:
Tanya Mabank, Kabamba B. Alexandre, Stephen C. Pelly, Ivan R. Green, Willem A. L. van Otterlo
Publikováno v:
ARKIVOC, Vol 2019, Iss 4, Pp 245-279 (2019)
Externí odkaz:
https://doaj.org/article/825637778e8d48dc87af0554584fdfc8
Publikováno v:
Biomedical Reports
Aptamers are nucleic acids selected by systematic evolution of ligands by exponential enrichment. They have potential as alternatives to antibodies in medical research and diagnostics, with the advantages of being non-immunogenic and relatively inexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9b1a9063e930bf3eb6d0d197a12ea1
https://doi.org/10.3892/br.2021.1491
https://doi.org/10.3892/br.2021.1491
Autor:
C. Johan van der Westhuizen, Vinesh Maharaj, Gerda Fouche, Phindiwe Chawuke, Luke Invernizzi, Narine van den Berg, Kabamba B. Alexandre, Tinotenda Shoko
Publikováno v:
Journal of ethnopharmacology. 277
Ethnopharmacological relevance There have been different methods proposed to prevent the sexual transmission of HIV-1 and many of them have centered on the use of anti-retrovirals as microbicides. Given that a large section of the African population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc21d316b86e4311c7daf8c9d024406
https://pubmed.ncbi.nlm.nih.gov/34033901
https://pubmed.ncbi.nlm.nih.gov/34033901
Publikováno v:
Virology. 544
Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dc75858ac380e64ebd10366e50686b
https://pubmed.ncbi.nlm.nih.gov/32174510
https://pubmed.ncbi.nlm.nih.gov/32174510
Publikováno v:
Virology. 497:69-80
The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1577f0b32c27fec63b736a28503b3d1
https://doi.org/10.1016/j.virol.2016.07.004
https://doi.org/10.1016/j.virol.2016.07.004
Publikováno v:
Biochemistry and Biophysics Reports
We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype C isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b55f88e3ffe62b53782395ba7c02a5f
http://europepmc.org/articles/PMC5613508
http://europepmc.org/articles/PMC5613508
Publikováno v:
MethodsX
MethodsX, Vol 7, Iss, Pp 101014-(2020)
MethodsX, Vol 7, Iss, Pp 101014-(2020)
HIV-1 infection is caused by cell-free and cell-associated viruses. Currently most of the assays used to screen potential HIV-1 entry inhibitors focus on the inhibition of cell-free viruses. One assay that is widely employed is the TZM-bl neutralizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9970d5c0db5cb5a69d7bf6a930526
https://doi.org/10.1016/j.mex.2020.101014
https://doi.org/10.1016/j.mex.2020.101014
Autor:
Ereck Chakauya, Penny L. Moore, Rachel Chikwamba, Nthabeleng Ranchobe, Elin S. Gray, James B. McMahon, Molati Nonyane, Barry R. O'Keefe, Kabamba B. Alexandre, Lynn Morris
Publikováno v:
Virology. 446:66-76
We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 strains cultured under esc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ae79f23497d6607f2d782c0be1d8e9
https://doi.org/10.1016/j.virol.2013.07.019
https://doi.org/10.1016/j.virol.2013.07.019
Autor:
Hazel T Mufhandu, Lynn Morris, Nancy Tumba, Kabamba B. Alexandre, Elin S. Gray, Makobetsa Khati, Maphuti C. Madiga, Penny L. Moore, Thandeka. Khoza, Constantinos Kurt Wibmer
Publikováno v:
Journal of Virology. 86:4989-4999
Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by the virion surface envelope (Env) glycoproteins, making it a desirable target for antiretroviral entry inhibitors. We previously isolated a family of gp120 binding RNA apt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e964cc57c576b1e7bb806421722bbb
https://doi.org/10.1128/jvi.06893-11
https://doi.org/10.1128/jvi.06893-11