Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

Autor: Stephen Boulton, Mathieu J.F. Crupi, Siddharth Singh, Madalina E. Carter-Timofte, Taha Azad, Bailey C. Organ, Xiaohong He, Rida Gill, Serge Neault, Taylor Jamieson, Jaahnavi Dave, Naziia Kurmasheva, Bradley Austin, Julia Petryk, Ragunath Singaravelu, Ben Zhen Huang, Noah Franco, Kaaviya Babu, Robin J. Parks, Carolina S. Ilkow, David Olagnier, John C. Bell

Publikováno v: Boulton, S, Crupi, M J F, Singh, S, Carter-Timofte, M E, Azad, T, Organ, B C, He, X, Gill, R, Neault, S, Jamieson, T, Dave, J, Kurmasheva, N, Austin, B, Petryk, J, Singaravelu, R, Huang, B Z, Franco, N, Babu, K, Parks, R J, Ilkow, C S, Olagnier, D & Bell, J C 2023, ' Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development ', The Journal of Biological Chemistry, vol. 299, no. 6, 104749 . https://doi.org/10.1016/j.jbc.2023.104749

The recent SARS-CoV-2 and mpox outbreaks have highlighted the need to expand our arsenal of broad-spectrum antiviral agents for future pandemic preparedness. Host-directed antivirals are an important tool to accomplish this as they typically offer pr

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