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Autor:
Chris Power, Gail Davies, Ilaria Gandin, Panagiotis Deloukas, Jennifer E. Huffman, Pascal Timshel, Albert V. Smith, A. Kong, Paul Lichtenstein, Joseph K. Pickrell, Philipp Koellinger, P. L. De Jager, Reedik Mägi, G. B. Chen, Neil Pendleton, B. V. Halldórsson, George Dedoussis, Antti-Pekka Sarin, Natalia Pervjakova, Veikko Salomaa, Simona Vaccargiu, Ozren Polasek, K. H. Jöckel, Elisabeth Steinhagen-Thiessen, Y. Milaneschi, Jessica D. Faul, Patricia A. Boyle, Patrik K. E. Magnusson, Igor Rudan, Christopher P. Nelson, Vilmundur Gudnason, John Attia, Jürgen Wellmann, Kristi Läll, Konstantin Strauch, Stuart J. Ritchie, Markus Perola, Nicola Pirastu, Klaus Bønnelykke, Robert Karlsson, R. de Vlaming, Liisa Keltigangas-Jarvinen, Thomas Meitinger, Riccardo E. Marioni, Anu Loukola, Barbera Franke, Reinhold Schmidt, Maël Lebreton, Sven Oskarsson, E. Mihailov, Harm-Jan Westra, David R. Weir, Aldi T. Kraja, Niek Verweij, Peter M. Visscher, Hans-Jörgen Grabe, Johannes H. Brandsma, Mark Adams, R. J. Scott, G. Thorleifsson, Tõnu Esko, Mika Kähönen, Saskia P. Hagenaars, Patrick Turley, Johannes Waage, Peter Lichtner, Dragana Vuckovic, Antonietta Robino, Henry Völzke, Lydia Quaye, C. de Leeuw, Marika Kaakinen, Wei Zhao, Abdel Abdellaoui, Reka Nagy, Pedro Marques-Vidal, Johan G. Eriksson, Alan F. Wright, Andres Metspalu, Lavinia Paternoster, Momoko Horikoshi, Jan A. Staessen, Tarunveer S. Ahluwalia, Tian Liu, Martin Kroh, Aldo Rustichini, Giorgia Girotto, Cristina Venturini, Lili Milani, Jennifer A. Smith, Ginevra Biino, Tessel E. Galesloot, Michael A. Horan, Gerardus A. Meddens, James F. Wilson, Francesco Cucca, Peter Vollenweider, Erika Salvi, P. J. van der Most, Jari Lahti, Campbell A, David Laibson, Andrew Bakshi, Wolfgang Hoffmann, Tomi Mäki-Opas, Andreas J. Forstner, C M van Duijn, Nicholas G. Martin, Jonathan Marten, Ute Bültmann, Olli T. Raitakari, David A. Bennett, A.G. Uitterlinden, J. E. De Neve, Ingrid B. Borecki, WD Hill, Bo Jacobsson, Antti Latvala, Katri Räikkönen, Michael B. Miller, Jonathan P. Beauchamp, S. J. van der Lee, Ilja Demuth, Stavroula Kanoni, Veronique Vitart, Elina Hyppönen, N. Eklund, Francesco P. Cappuccio, Robert F. Krueger, Maria Pina Concas, Jaime Derringer, F. J.A. Van Rooij, Helena Schmidt, Patrick J. F. Groenen, Valur Emilsson, Rico Rueedi, Aysu Okbay, Georg Homuth, Edith Hofer, W. E. R. Ollier, Hannah Campbell, Paolo Gasparini, Mark Alan Fontana, Magnus Johannesson, Seppo Koskinen, Christopher F. Chabris, Jouke-Jan Hottenga, Christine Meisinger, Kari Stefansson, Jun Ding, Tia Sorensen, Brenda W.J.H. Penninx, Michelle N. Meyer, James J. Lee, Diego Vozzi, Gonneke Willemsen, K. Petrovic, Sarah E. Medland, Mary F. Feitosa, Henning Tiemeier, L. J. Launer, William G. Iacono, Massimo Mangino, Tune H. Pers, S. E. Baumeister, Christopher Oldmeadow, Grant W. Montgomery, Marjo-Riitta Järvelin, Jaakko Kaprio, Catharine R. Gale, S.F.W. Meddens, Kevin Thom, Klaus Berger, Pablo V. Gejman, Lude Franke, Gyda Bjornsdottir, Daniel J. Benjamin, Steven F. Lehrer, Krista Fischer, Alan R. Sanders, S. Ulivi, Katharina E. Schraut, Tim D. Spector, Amy Hofman, Matt McGue, Terho Lehtimäki, D. C. Liewald, Hans Bisgaard, L. Eisele, Astanand Jugessur, George Davey Smith, T.B. Harris, A.R. Thurik, Cornelius A. Rietveld, David Schlessinger, Z. Kutalik, David J. Porteous, Lynne J. Hocking, N J Timpson, A. Palotie, Lambertus A. Kiemeney, Ian J. Deary, Sharon L.R. Kardia, Peter K. Joshi, Nilesh J. Samani, Michael A. Province, Börge Schmidt, Richa Gupta, Carmen Amador, Erin B. Ware, Joyce Y. Tung, Ioanna-Panagiota Kalafati, Lars Bertram, Caroline Hayward, P. van der Harst, Penelope A. Lind, Kadri Kaasik, N.A. Furlotte, Sarah E. Harris, B. St Pourcain, Susan M. Ring, Zhihong Zhu, Alexander Teumer, Behrooz Z. Alizadeh, Judith M. Vonk, Blair H. Smith, A Payton, Wouter J. Peyrot, Jacob Gratten, Douglas F. Levinson, C Gieger, Leanne M. Hall, Andrew Heath, Mario Pirastu, Peter Eibich, Nancy L. Pedersen, Ronny Myhre, Antonio Terracciano, David M. Evans, Raymond A. Poot, Uwe Völker, Dorret I. Boomsma, Clemens Baumbach, Unnur Thorsteinsdottir, Ivana Kolcic, Jia-Shu Yang, Dalton Conley, A. A. Vinkhuyzen, Danielle Posthuma, Karl-Oskar Lindgren, Olga Rostapshova, Jonas Bacelis, Daniele Cusi, Yong Qian, Bjarni Gunnarsson, George McMahon, Elizabeth G. Holliday, Pamela A. F. Madden, David A. Hinds, David Cesarini, Jianxin Shi, Najaf Amin, Dale R. Nyholt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of Ame, 113(47), 13366-13371. National Academy of Sciences
Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13366-13371. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Abdellaoui, A, Hottenga, J J, Willemsen, G, Boomsma, D I, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J & de Vlaming, R 2016, ' Genetic variants linked to education predict longevity. ', Proceedings of the National Academy of Sciences of the United States of America, no. 113, 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13366-13371. National Academy of Sciences
Social Science Genetic Association Consortium 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D, Campbell, A, Wilson, J F, Hayward, C, Esko, T & Porteous, D J & Gale, C V 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences (PNAS), vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences USA, 113, 47, pp. 13366-13371
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J, Social Science Genetic Association Consortium & Pendleton, N 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences of the United States of America, 13366-13371. National Acad Sciences
ISSUE=113;STARTPAGE=13366;ENDPAGE=13371;ISSN=0027-8424;TITLE=Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 113, 13366-13371
Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13366-13371. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Abdellaoui, A, Hottenga, J J, Willemsen, G, Boomsma, D I, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J & de Vlaming, R 2016, ' Genetic variants linked to education predict longevity. ', Proceedings of the National Academy of Sciences of the United States of America, no. 113, 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13366-13371. National Academy of Sciences
Social Science Genetic Association Consortium 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D, Campbell, A, Wilson, J F, Hayward, C, Esko, T & Porteous, D J & Gale, C V 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences (PNAS), vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences USA, 113, 47, pp. 13366-13371
Marioni, R E, Ritchie, S J, Joshi, P K, Hagenaars, S P, Okbay, A, Fischer, K, Adams, M J, Hill, W D, Davies, G, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, D C, Campbell, A, Wilson, J F, Hayward, C, Esko, T, Porteous, D J, Gale, C R, Deary, I J, Social Science Genetic Association Consortium & Pendleton, N 2016, ' Genetic variants linked to education predict longevity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 47, pp. 13366-13371 . https://doi.org/10.1073/pnas.1605334113
Proceedings of the National Academy of Sciences of the United States of America, 13366-13371. National Acad Sciences
ISSUE=113;STARTPAGE=13366;ENDPAGE=13371;ISSN=0027-8424;TITLE=Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 113, 13366-13371
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Bioba
Autor:
Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ulrich A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Zudina L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., González KSG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Faggian A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Maina JG; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Todorov PV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sharapov S; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., David A; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK., Marullo L; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rujan RM; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gao Η; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Εvangelou Ε; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Benyamin B; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Willems SM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Meisinger C; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Corrêa IR Jr; New England Biolabs, Ipswich, MA, USA., Farber-Eger E; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schmidberger J; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hveem K; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Shmeliov A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Haenle M; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore., Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK., Salem V; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Florez JC; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Montgomery G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Tzoulaki I; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Brittain EL; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Groop L; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Deganutti G; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Demirkan A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Reynolds CA; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Aulchenko YS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk., Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
Publikováno v:
Nature genetics [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. Date of Electronic Publication: 2023 Sep 07.
Autor:
Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu., Emmerich A; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Pillon NJ; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Moore T; Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA., Hemerich D; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cornelis MC; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mazzaferro E; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Broos S; Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.; Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium., Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Chong M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; GlaxoSmithKline, Cambridge, MA, USA., Berry D; Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore., Dueker ND; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.; Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA., Kasbohm E; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Institute of Mathematics and Computer Science, University of Greifswald, Greifswald, Germany., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Hall LM; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Haller T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK., Hillis DA; Genetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA, USA., Huikari V; Institute of Health Sciences, University of Oulu, Oulu, Finland., Heard-Costa N; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Holzapfel C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.; Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Johansson Å; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Jørgensen AM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kaakinen MA; Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Kerr KF; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kim B; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea., Koolhaas CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Kutalik Z; University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland., Lagou V; Wellcome Sanger Institute, Cambridge, UK., Lind PA; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Lorentzon M; Geriatric Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital Mölndal, Gothenburg, Sweden.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Metzendorf C; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Monroe KR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Pacolet A; Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium., Pérusse L; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.; Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada., Pool R; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Richmond RC; MRC Integrative Epidemiology Unit and Avon Longitudinal Study of Parents and Children, University of Bristol Medical School, Population Health Sciences and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK., Rivera NV; Respiratory Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Rheumatology Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Center of Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden., Robiou-du-Pont S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Schulz CA; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vanmunster M; Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium., van Rooij FJA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zhang X; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; School of Public Health, Department of Biostatistics, Shandong University, Jinan, China., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK., Balslev-Harder MN; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Baumeister SE; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; University of Münster, Münster, Germany., Beilby J; Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Brage S; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bruinenberg M; Lifelines Cohort Study, Groningen, the Netherlands., Ekelund U; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Cole JW; Vascular Neurology, Department of Neurology, University of Maryland School of Medicine and the Baltimore VAMC, Baltimore, MD, USA., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Enroth S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fernandez-Rhodes L; Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA., Fohner AE; Department of Epidemiology, Institute of Public Health Genetics, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Franco OH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland., Galesloot TE; Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands., Gordon SD; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hartman CA; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heiss G; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Hui J; Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.; School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.; Busselton Population Medical Research Institute, Busselton, Western Australia, Australia., Illig T; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Jago R; Centre for Exercise Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK., James A; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Humanity Inc, Boston, MA, USA., Jung T; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea., Kähönen M; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, Croatia., Kraft PP; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA., Li A; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Vidal PM; Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Medland SE; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology and Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia., Milaneschi Y; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands., Moscati A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Musk B; Busselton Population Medical Research Institute, Busselton, Western Australia, Australia., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Peters A; Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Power C; Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Reedik M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Ryan K; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Sarzynski MA; Department of Exercise Science, University of South Carolina, Columbia, SC, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Siggeirsdottir K; Icelandic Heart Association, Kópavogur, Iceland., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kópavogur, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Sonestedt E; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Strøm M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo KK; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany., Tremblay A; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.; Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada., Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Vangipurapu J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., van Schoor N; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands., Völker U; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Williams K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA., Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Zillikens MC; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Zonderman AB; Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA., Ameur A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bandinelli S; Geriatric Unit, Azienda USL Toscana Centro, Florence, Italy., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Smith GD; MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK., de Geus EJC; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Deldicque L; Faculty of Movement and Rehabilitation Sciences, Institute of Neuroscience, UC Louvain, Louvain-la-Neuve, Belgium., Dörr M; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Fox C; Genetics and Pharmacogenomics (GpGx), Merck Research Labs, Boston, MA, USA., Garland T Jr; Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA., Gudnason V; Icelandic Heart Association, Kópavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gyllensten U; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Hyppönen E; Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK., Jarvelin MR; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK., Johnson WC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kiemeney LA; Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Martin NG; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Melbye M; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; K.G.Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Meyre D; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Orho-Melander M; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Pare G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Park T; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.; Department of Statistics, Seoul National University, Seoul, South Korea., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Penninx BWJH; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Polasek O; University of Split School of Medicine, Split, Croatia., Prokopenko I; Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.; UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol Medical School, University of Bristol, Bristol, UK., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA., van der Velde N; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Section of Geriatrics, Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Vollenweider P; Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany., Voortman T; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Waeber G; Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Hevener AL; Division of Endocrinology, Department of Medicine, University of California, Los Angeles, CA, USA., Krook A; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Zierath JR; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Thomis MAI; Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoed MD; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden. marcel.den_hoed@igp.uu.se.
Publikováno v:
Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1332-1344. Date of Electronic Publication: 2022 Sep 07.
Autor:
Hassan S; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, India., Kaakinen MA; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK., Draisma H; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK., Zudina L; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK., Ganie MA; Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences (SKIMS), Srinagar 190011, India., Rashid A; Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences (SKIMS), Srinagar 190011, India., Balkhiyarova Z; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK., Kiran GS; Department of Food Science and Technology, School of Life Sciences, Pondicherry University, Puducherry 605014, India., Vogazianos P; Stremble Ventures Ltd., Limassol 4710, Cyprus., Shammas C; AVVA Pharmaceuticals Ltd., Limassol 4710, Cyprus., Selvin J; Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, India., Antoniades A; Stremble Ventures Ltd., Limassol 4710, Cyprus., Demirkan A; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK.; Department of Genetics, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands., Prokopenko I; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK.; Laboratory UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, F-59000 Lille, France.
Publikováno v:
Genes [Genes (Basel)] 2022 Feb 18; Vol. 13 (2). Date of Electronic Publication: 2022 Feb 18.
Autor:
Ronkainen J; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Nedelec R; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Atehortua A; Artificial Intelligence in Medicine Lab (BCN-AIM), University of Barcelona, Barcelona, Spain.; Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain., Balkhiyarova Z; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; Bashkir State Medical University, Department of Endocrinology, Ufa, Russian Federation., Cascarano A; Artificial Intelligence in Medicine Lab (BCN-AIM), University of Barcelona, Barcelona, Spain.; Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain., Ngoc Dang V; Artificial Intelligence in Medicine Lab (BCN-AIM), University of Barcelona, Barcelona, Spain.; Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain., Elhakeem A; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom., van Enckevort E; Department of Genetics and Genomics Coordination Center, University of Groningen, Groningen, the Netherlands., Goncalves Soares A; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom., Haakma S; Department of Genetics and Genomics Coordination Center, University of Groningen, Groningen, the Netherlands., Halonen M; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Heil KF; Artificial Intelligence in Medicine Lab (BCN-AIM), University of Barcelona, Barcelona, Spain.; Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain., Heiskala A; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Hyde E; Department of Genetics and Genomics Coordination Center, University of Groningen, Groningen, the Netherlands., Jacquemin B; University of Rennes, INSERM, School of Advanced Studies in Public Health (EHESP), Research Institute for Environmental and Occupational Health, UMR_S 1085, Rennes, France., Keikkala E; Finnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Kerckhoffs J; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Klåvus A; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Kopinska JA; Department of Social Sciences and Economics, Sapienza University of Rome, Rome, Italy., Lepeule J; Grenoble Alpes University, INSERM, CNRS, Institute for Advanced Biosciences, Grenoble, France., Marazzi F; CEIS Tor Vergata, Centre for Economic and International Studies, University of Rome Tor Vergata, Rome, Italy., Motoc I; Amsterdam UMC, Epidemiology and Data Science, University of Amsterdam, Amsterdam Public Health, Amsterdam, the Netherlands., Näätänen M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Ribbenstedt A; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Rundblad A; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway., Savolainen O; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.; Department of Biology and Biological Engineering, Chalmers Mass Spectrometry Infrastructure, Chalmers University of Technology, Gothenburg, Sweden., Simonetti V; R&D Department, Ab.Acus srl, Milan, Italy., de Toro Eadie N; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St. Mary's Hospital, London, United Kingdom., Tzala E; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St. Mary's Hospital, London, United Kingdom., Ulrich A; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom., Wright T; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St. Mary's Hospital, London, United Kingdom., Zarei I; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., d'Amico E; R&D Department, Ab.Acus srl, Milan, Italy., Belotti F; CEIS Tor Vergata, Centre for Economic and International Studies, University of Rome Tor Vergata, Rome, Italy.; Department of Economics and Finance, University of Rome Tor Vergata, Rome, Italy., Brunius C; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Castleton C; CyNexo srl, Trivignano Udinese, Italy., Charles MA; Center for Research in Epidemiology and Statistics, INSERM, INRAE, University of Paris, Paris, France.; Ined, INSERM, EFS, Elfe Joint Unit, Aubervilliers, France., Gaillard R; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Hanhineva K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Biochemistry, University of Turku, Turku, Finland., Hoek G; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Holven KB; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway.; National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Kaakinen MA; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Kajantie E; Finnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Lakka T; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Matthews J; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway., Piano Mortari A; CEIS Tor Vergata, Centre for Economic and International Studies, University of Rome Tor Vergata, Rome, Italy., Vääräsmäki M; Finnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Voortman T; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Webster C; Beta Technology Ltd, Doncaster, United Kingdom., Zins M; Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France., Atella V; CEIS Tor Vergata, Centre for Economic and International Studies, University of Rome Tor Vergata, Rome, Italy.; Department of Economics and Finance, University of Rome Tor Vergata, Rome, Italy.; Stanford University, Stanford, CA., Bulgheroni M; R&D Department, Ab.Acus srl, Milan, Italy., Chadeau-Hyam M; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St. Mary's Hospital, London, United Kingdom., Conti G; Department of Economics, University College London, London, United Kingdom.; Social Research Institute, London, United Kingdom., Evans J; Beta Technology Ltd, Doncaster, United Kingdom., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Heude B; Center for Research in Epidemiology and Statistics, INSERM, INRAE, University of Paris, Paris, France., Järvelin MR; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St. Mary's Hospital, London, United Kingdom., Kolehmainen M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Landberg R; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Lekadir K; Artificial Intelligence in Medicine Lab (BCN-AIM), University of Barcelona, Barcelona, Spain.; Department of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain., Parusso S; CyNexo srl, Trivignano Udinese, Italy., Prokopenko I; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation., de Rooij SR; Amsterdam UMC, Epidemiology and Data Science, University of Amsterdam, Amsterdam Public Health, Amsterdam, the Netherlands., Roseboom T; Amsterdam UMC, Epidemiology and Data Science, University of Amsterdam, Amsterdam Public Health, Amsterdam, the Netherlands.; Gynaecology and Obstetrics, Amsterdam Reproduction and Development Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Swertz M; Department of Genetics and Genomics Coordination Center, University of Groningen, Groningen, the Netherlands., Timpson N; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom., Ulven SM; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway., Vermeulen R; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.; Julius Center, University Medical Center Utrecht, Utrecht, the Netherlands., Juola T; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Sebert S; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
Publikováno v:
Environmental epidemiology (Philadelphia, Pa.) [Environ Epidemiol] 2021 Dec 28; Vol. 6 (1), pp. e184. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2022).
Autor:
Chen J; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA., Marenne G; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France., Varshney A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Corbin LJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Willems SM; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Zhang X; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China., Horikoshi M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan., Boutin TS; Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, Edinburgh, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Waage J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Chan KHK; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.; Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, China., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Anasanti MD; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heikkinen J; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Hong J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Huo S; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., März W; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Moreno-Macias H; Department of Economics, Metropolitan Autonomous University, Mexico City, Mexico., Ndungu A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., North KE; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Raulerson CK; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rohde R; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; HPI Digital Health Center, Digital Health and Personalized Medicine, Hasso Plattner Institute, Potsdam, Germany., Sim X; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Southam L; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Stewart ID; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Wang Y; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Appel EVR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Brody JA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Burtt NP; Metabolism Program, Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Cabrera CP; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Cade BE; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Chai JF; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen BH; Department of Epidemiology, The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Chiu YF; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Demirkan A; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Engmann J; Institute of Cardiovascular Science, University College London, London, UK., Fatumo SA; Uganda Medical Informatics Centre (UMIC), MRC/UVRI and London School of Hygiene & Tropical Medicine (Uganda Research Unit), Entebbe, Uganda.; London School of Hygiene & Tropical Medicine, London, UK.; H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria., Gayán J; Bioinfosol, Sevilla, Spain., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gong JH; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Gustafsson S; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hai Y; Department of Statistics, The University of Auckland, Science Center, Auckland, New Zealand., Hartwig FP; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., He J; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Heianza Y; Department of Epidemiology, Tulane University Obesity Research Center, Tulane University, New Orleans, LA, USA., Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Huerta-Chagoya A; Molecular Biology and Genomic Medicine Unit, National Council for Science and Technology, Mexico City, Mexico.; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Jensen RA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Kooner IK; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Lai S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Lange LA; Department of Medicine, Divison of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Langefeld CD; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Lauzon M; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Li M; Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA., Ligthart S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Liu J; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden., Mangino M; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK., Marzi C; Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Montasser ME; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Nag A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nakatochi M; Public Health Informatics Unit, Department of Integrated Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Noce D; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Pistis G; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raffield L; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Robertson NR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ryan K; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Sanna S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Saxena R; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Sennblad B; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Setoh K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland., Sparsø T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Strawbridge RJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., van den Akker E; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, the Netherlands.; Department of Biomedical Data Sciences, Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genomics PLC, Oxford, UK., Vogel M; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Wang H; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Wang N; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Wood AR; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zafarmand MH; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Zhao JH; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Arzumanyan Z; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Astrup A; Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Baldassarre D; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Beekman M; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Blüher M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, MD, USA., Bornstein SR; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Cai Q; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., de Geus EJC; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Dehghan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Farmaki AE; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Frånberg M; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Fuchsberger C; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Gao Y; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Herder C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Düsseldorf, Germany., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Hsieh CH; Internal Medicine, Endocrine and Metabolism, Tri-Service General Hospital, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hsueh WA; Internal Medicine, Endocrinology, Diabetes and Metabolism, Diabetes and Metabolism Research Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Igase M; Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson WC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Odense, Denmark., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Kalyani RR; Department of Medicine, Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kandeel FR; Clinical Diabetes, Endocrinology and Metabolism, Translational Research and Cellular Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kiess W; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, Croatia., Kuulasmaa T; Institute of Biomedicine, Bioinformatics Center, Univeristy of Eastern Finland, Kuopio, Finland., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lam K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, the Philippines.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, the Philippines., Lemaitre RN; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Li H; State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Lin SY; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.; National Defense Medical Center, National Yang-Ming University, Taipei, Taiwan., Lindström J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lorenzo C; Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA., Matsubara T; Department of Internal Medicine, Aichi Gakuin University School of Dentistry, Nagoya, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mingrone G; Department of Diabetes, Diabetes, and Nutritional Sciences, James Black Centre, King's College London, London, UK., Mooijaart S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Moon S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadler JL; Department of Medicine and Pharmacology, New York Medical College School of Medicine, Valhalla, NY, USA., Nelis M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Norris JM; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ohyagi Y; Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Toon, Japan., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia.; Gen-Info, Zagreb, Croatia., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Raven D; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Reilly DF; Genetics and Pharmacogenomics, Merck Sharp & Dohme, Kenilworth, NJ, USA., Reiner A; Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Rivideneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health, The Usher Institute, University of Edinburgh, Edinburgh, UK., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Schürmann A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Shi J; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China., Stringham HM; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teslovich TM; Sarepta Therapeutics, Cambridge, MA, USA., Thuesen B; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Timmers PRHJ; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Tremoli E; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Uitterlinden A; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., van Dam RM; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., van Vliet-Ostaptchouk JV; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vangipurapu J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Wang T; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Willems van Dijk K; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Zemunik T; Department of Human Biology, University of Split School of Medicine, Split, Croatia., Abecasis GR; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Aguilar-Salinas CA; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición and Tec Salud, Mexico City, Mexico.; Instituto Tecnológico y de Estudios Superiores de Monterrey Tec Salud, Monterrey, Mexico., Alarcón-Riquelme ME; Department of Medical Genomics, Pfizer/University of Granada/Andalusian Government Center for Genomics and Oncological Research (GENYO), Granada, Spain.; Institute for Environmental Medicine, Chronic Inflammatory Diseases, Karolinska Institutet, Solna, Sweden., An P; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Aviles-Santa L; Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, Bethesda, MD, USA., Becker DM; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Beilin LJ; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Black C; Aberdeen Centre for Health Data Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK., Boehnke M; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Böhm BO; Division of Endocrinology and Diabetes, Graduate School of Molecular Endocrinology and Diabetes, University of Ulm, Ulm, Germany.; LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London, UK, Singapore, Singapore., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Boomsma DI; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institut, University Potsdam, Potsdam, Germany., Buchanan TA; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Canouil M; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Université de Lille, Lille, France.; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, MD, USA., Correa A; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Cucca F; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Kallithea, Greece., Elmståhl S; Department of Clinical Sciences, Lund University, Malmö, Sweden., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy., Ferrucci L; Intramural Research Program, National Institute of Aging, Baltimore, MD, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Frayling TM; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Froguel P; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Université de Lille, Lille, France.; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College London, London, UK., Gigante B; Department of Medicine, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Grallert H; Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grimsgaard S; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., Groop L; Diabetes Centre, Lund University, Lund, Sweden.; Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hamsten A; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Heckbert SR; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., James PS; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu Univerisity Hospital, OYS, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Institute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kaleebu P; MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.; Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Körner A; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; IFB Adiposity Diseases, University of Leipzig Medical Center, Leipzig, Germany., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Institute of Primary Care and Public Health, Division of Biostatistics, University of Lausanne, Lausanne, Switzerland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Leander K; Institute of Environmental Medicine, Cardiovascular and Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden., Li H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lin X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lind L; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden., Lindgren C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Liu S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Mori TA; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., O'Connell JR; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Oldehinkel AJ; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ong KK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Qi L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Raffel LJ; Department of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, Irvine, CA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Redline S; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Havard Medical School, Boston, MA, USA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Saaristo TE; Tampere, Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Sandhu M; Department of Medicine, University of Cambridge, Cambridge, UK., Saramies J; South Karelia Central Hospital, Lappeenranta, Finland., Schneiderman N; Department of Psychology, University of Miami, Miami, FL, USA., Schwarz P; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine, Dresden, Germany., Scott LJ; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Slagboom PE; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Small KS; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sofer T; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Sørensen TIA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Stanton A; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Steves CJ; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; Department of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, UK., Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Sun L; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tai ES; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Cardiovascular and Metabolic Disease Signature Research Program, Duke-NUS Medical School, Singapore, Singapore., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Tuomilehto J; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie T; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico.; Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., van der Harst P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Duijn C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Vitart V; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Vrijkotte TGM; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wagenknecht LE; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Walker M; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wei WB; Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Willemsen G; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Xiang AH; Department of Research and Evaluation, Kaiser Permanente of Southern California, Pasadena, CA, USA., Yanek LR; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yengo L; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Yokota M; Kurume University School of Medicine, Kurume, Japan., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Prokopenko I; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK., Leong A; Harvard Medical School, Boston, MA, USA.; Department of Medicine, General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Diabetes Unit and Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Parker SCJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wheeler E; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. ines.barroso@exeter.ac.uk.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK. ines.barroso@exeter.ac.uk.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. ines.barroso@exeter.ac.uk.
Publikováno v:
Nature genetics [Nat Genet] 2021 Jun; Vol. 53 (6), pp. 840-860. Date of Electronic Publication: 2021 May 31.
Autor:
Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, The Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, The Netherlands.; Department of Physiology, Maastricht University, Maastricht, The Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, The Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, The Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 995. Date of Electronic Publication: 2021 Feb 08.
Autor:
Loizidou EM; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK., Kucherenko A; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Tatarskyy P; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Chernushyn S; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Livshyts G; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Gulkovskyi R; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Vorobiova I; Institute of Paediatrics, Obstetrics and Gynaecology of the National Academy of Medical Sciences, 04050 Kiev, Ukraine., Antipkin Y; Institute of Paediatrics, Obstetrics and Gynaecology of the National Academy of Medical Sciences, 04050 Kiev, Ukraine., Gorodna O; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine., Kaakinen MA; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.; Section of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford GU2 7XH, UK., Prokopenko I; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.; Section of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford GU2 7XH, UK.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, 119192 Ufa, Russia., Livshits L; Institute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Publikováno v:
Genes [Genes (Basel)] 2021 Jan 05; Vol. 12 (1). Date of Electronic Publication: 2021 Jan 05.
Autor:
Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2021 Jan 05; Vol. 12 (1), pp. 24. Date of Electronic Publication: 2021 Jan 05.
Autor:
Prokopenko I; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Miyakawa G; Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.; Max Planck Institute for Molecular Genetics, Berlin, Germany., Zheng B; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK., Heikkinen J; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK.; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK., Petrova Quayle D; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK., Udeh-Momoh C; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK., Claringbould A; Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands., Neumann J; Nuffield Department of Clinical Neuroscience, Neuropathology and Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Haytural H; Nuffield Department of Clinical Neuroscience, Neuropathology and Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Kaakinen MA; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK., Loizidou E; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK., Meissner E; Max Planck Institute for Molecular Genetics, Berlin, Germany., Bertram L; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Gveric DO; Multiple Sclerosis and Parkinson's Tissue Bank, Imperial College London, London, UK., Gentleman SM; Neuropathology Unit, Department of Medicine, Imperial College London, London, UK., Attems J; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK., Perneczky R; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany., Arzberger T; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany.; Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany., Muglia P; Neuroscience Discovery Medicine, UCB Pharma, Brussels Area, Belgium., Lill CM; Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK., Parkkinen L; Nuffield Department of Clinical Neuroscience, Neuropathology and Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Middleton LT; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Neurology, Public Health Directorate, Imperial College NHS Healthcare Trust Hospitals, London, UK.
Publikováno v:
Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2019 Nov 20; Vol. 5, pp. 814-824. Date of Electronic Publication: 2019 Nov 20 (Print Publication: 2019).