The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

Autor: Wojciech, Stefanie, Ahmad, Raise, Belaid-Choucair, Zakia, Journé, Anne-Sophie, Gallet, Sarah, Dam, Julie, Daulat, Avais, Ndiaye-Lobry, Delphine, Lahuna, Olivier, Karamitri, Angeliki, Guillaume, Jean-Luc, Do Cruzeiro, Marcio, Guillonneau, François, Saade, Anastasia, Clément, Nathalie, Courivaud, Thomas, Kaabi, Nawel, Tadagaki, Kenjiro, Delagrange, Philippe, Prévot, Vincent, Hermine, Olivier, Prunier, Céline, Jockers, Ralf

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1216. 〈10.1038/s41467-018-03609-x〉
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, 2018, 9 (1), pp.1216. ⟨10.1038/s41467-018-03609-x⟩

Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative complex between TβRI and the orphan GPR50, belonging to the G protein-coupled recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::43045d9949b1a82435f26acf42035d22
https://hal.archives-ouvertes.fr/hal-01815738