Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ka-Wai Leong"'
Autor:
Haoqing Shen, Omer An, Xi Ren, Yangyang Song, Sze Jing Tang, Xin-Yu Ke, Jian Han, Daryl Jin Tai Tay, Vanessa Hui En Ng, Fernando Bellido Molias, Priyankaa Pitcheshwar, Ka Wai Leong, Ker-Kan Tan, Henry Yang, Leilei Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA editing and circRNAs are involved in tumorigenesis. Here the authors report that ADARs regulate the circular transcriptome in a bidirectional manner through and beyond their editing function in multiple cancer cells.
Externí odkaz:
https://doaj.org/article/f2d8d4caaf374a63a3b50fdc64d144c8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4931-4940 (2021)
Microsatellite instability (MSI), a phenotype displayed as deletions/insertions of repetitive genomic sequences, has drawn great attention due to its application in cancer including diagnosis, prognosis and immunotherapy response prediction. Several
Externí odkaz:
https://doaj.org/article/be7ae32254934254b2e8504512a4e937
Autor:
Sze Jing Tang, Haoqing Shen, Omer An, HuiQi Hong, Jia Li, Yangyang Song, Jian Han, Daryl Jin Tai Tay, Vanessa Hui En Ng, Fernando Bellido Molias, Ka Wai Leong, Priyankaa Pitcheshwar, Henry Yang, Leilei Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.
Externí odkaz:
https://doaj.org/article/97121b7cd8a54dd7a91a545e6f93aeff
Autor:
Leilei Chen, Jonathan Göke, Jasmin Xin Jia Teo, Chen Ying, Max Wei Jie Lim, Vanessa Hui En Ng, Yangyang Song, Omer An, Ka Wai Leong, Andre Sim, Fernando Bellido Molias
Supplementary Data - Main File
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db401fff25140e023d72a34260f90ab
https://doi.org/10.1158/0008-5472.22529135
https://doi.org/10.1158/0008-5472.22529135
Autor:
Leilei Chen, Jonathan Göke, Jasmin Xin Jia Teo, Chen Ying, Max Wei Jie Lim, Vanessa Hui En Ng, Yangyang Song, Omer An, Ka Wai Leong, Andre Sim, Fernando Bellido Molias
List of ncNATs expressed in TCGA tumors, for which their associated sense genes have two active alternative promoters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5053164e5f2db281536f782150051b23
https://doi.org/10.1158/0008-5472.22529129
https://doi.org/10.1158/0008-5472.22529129
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Verification of detection power calculation. Comparison between the predicted detection power of 18 replicates and the actual fraction of those replicates that were called MRD+. 18 independent samples from a 1:100k dilution were probed with a 488 SNV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64af9516783cfdb147d8e83ff11e720a
https://doi.org/10.1158/1078-0432.22478915.v1
https://doi.org/10.1158/1078-0432.22478915.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Early stage breast cancer cohort. (A) Overview of subtype distribution of cohort as well as the timing of blood draws relative to surgery and treatment. (B) REMARK diagram of the early stage breast cancer cohort. (C) Distribution of the number of mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a78d91244c2f15245d1f854b249187
https://doi.org/10.1158/1078-0432.22478927.v1
https://doi.org/10.1158/1078-0432.22478927.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Purpose:Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1,000-fold lower e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22733ab4686b715c65b3b05813aea31f
https://doi.org/10.1158/1078-0432.c.6530084
https://doi.org/10.1158/1078-0432.c.6530084
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Overview schematic of MRD assay. MRD assay workflow from characterizing a primary tumor to determining if a blood draw contains evidence of residual disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109f474d4909e0ad619512094777e084
https://doi.org/10.1158/1078-0432.22478924.v1
https://doi.org/10.1158/1078-0432.22478924.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Validation of tumor fraction confidence interval and effects of biological variability on tumor fraction inference. (A) Confidence intervals inferred from simulated data were aggregated into coverage probability for each condition and compared agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b046730e8f622b0bc9925a544e1dbd
https://doi.org/10.1158/1078-0432.22478912.v1
https://doi.org/10.1158/1078-0432.22478912.v1