Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ka-Hei Siu"'
Autor:
Lauren Narcross, Michael E. Pyne, Kaspar Kevvai, Ka-Hei Siu, John E. Dueber, Vincent J. J. Martin
The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises over 2,500 members, including the pharmaceuticals morphine, codeine, and papaverine as well as the antibiotics sanguinarine and chelerythrine used in animal hus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f6998ca3d3e8ce612be2b7976df778
https://doi.org/10.1101/2023.05.19.541502
https://doi.org/10.1101/2023.05.19.541502
Autor:
Jie Ren Gerald Har, Bryan von Hagel, Alec Agee, Ka-Hei Siu, Eleftherios T. Papoutsakis, Maciek R. Antoniewicz, R. Kyle Bennett
Publikováno v:
Metabolic Engineering. 61:1-10
Synthetic methylotrophy aims to engineer methane and methanol utilization pathways in platform hosts like Escherichia coli for industrial bioprocessing of natural gas and biogas. While recent attempts to engineer synthetic methylotrophs have proved s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881ac8aa1da37d7d5f39a5a15ffb2c01
https://doi.org/10.1016/j.ymben.2020.04.007
https://doi.org/10.1016/j.ymben.2020.04.007
Autor:
Wilfred Chen, Ka-Hei Siu
Publikováno v:
Nature Chemical Biology. 15:217-220
Predictable control over gene expression is essential to elicit desired synthetic cellular phenotypes. Although CRISPR–Cas9 offers a simple RNA-guided method for targeted transcriptional control, it lacks the ability to integrate endogenous cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db933c42652ee8284cc126223bba45f8
https://doi.org/10.1038/s41589-018-0186-1
https://doi.org/10.1038/s41589-018-0186-1
Publikováno v:
Current Opinion in Biotechnology. 36:98-106
Controlling local concentrations of reactants, intermediates, and enzymes in synthetic pathways is critical for achieving satisfactory productivity of any desired products. An emerging approach to exert control over local concentrations is the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e48a7d048cf09f855a40a12d8ce76
https://doi.org/10.1016/j.copbio.2015.08.009
https://doi.org/10.1016/j.copbio.2015.08.009
Publikováno v:
Biotechnology and Bioengineering. 112:1495-1505
For many applications, increasing synergy between distinct proteins through organization is important for the specificity, regulation, and overall reaction efficiency. Although there are many examples of protein complexes in nature, a generalized met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90196b27587578f0127da4b990a0b56f
https://doi.org/10.1002/bit.25637
https://doi.org/10.1002/bit.25637
Autor:
May N. Taw, Ka-Hei Siu, Robert J. Conrado, Larry P. Walker, Jessica C. Stark, Donna M. Gibson, Brian C. King, Matthew P. DeLisa, Jason T. Boock
Publikováno v:
Journal of Molecular Biology. 427:1451-1463
Heterologous expression of many proteins in bacteria, yeasts, and plants is often limited by low titers of functional protein. To address this problem, we have created a two-tiered directed evolution strategy in Escherichia coli that enables optimiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6c7c5c4ca923389f524d24bd4034e7
https://doi.org/10.1016/j.jmb.2015.01.003
https://doi.org/10.1016/j.jmb.2015.01.003
Autor:
Ka-Hei Siu, Wilfred Chen
Publikováno v:
ACS synthetic biology. 6(8)
Synthetic control strategies using signaling peptides to regulate and coordinate cellular behaviors in multicellular organisms and synthetic consortia remain largely underdeveloped because of the complexities necessitated by heterologous peptide expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b913231879b30051489128a20888be
https://pubmed.ncbi.nlm.nih.gov/28505429
https://pubmed.ncbi.nlm.nih.gov/28505429
Publikováno v:
Biotechnology and bioengineering. 112(8)
For many applications, increasing synergy between distinct proteins through organization is important for the specificity, regulation, and overall reaction efficiency. Although there are many examples of protein complexes in nature, a generalized met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e72f4e29d43ee914c39dbdecec3e4151
https://pubmed.ncbi.nlm.nih.gov/25943909
https://pubmed.ncbi.nlm.nih.gov/25943909
Publikováno v:
Current opinion in biotechnology. 28
Proteins inherently are not designed to be standalone entities. Whether it is a multi-step biochemical reaction or a signaling event that triggers several other cascading events, proteins are naturally designed to function cohesively. Several natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3705a4f8a54dafc9077ea57d1f02384d
https://pubmed.ncbi.nlm.nih.gov/24832076
https://pubmed.ncbi.nlm.nih.gov/24832076
Autor:
Rebecca Chen1, Qi Chen1, Kim, Heejae1, Ka-Hei Siu1, Qing Sun1, Shen-Long Tsai2, Wilfred Chen1 wilfred@udel.edu
Publikováno v:
Current Opinion in Biotechnology. Aug2014, Vol. 28, p59-68. 10p.