Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Ka Wan Li"'
Autor:
Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate g
Externí odkaz:
https://doaj.org/article/8c2d7e6c8ed449b1816eb6adb95fcab9
Autor:
Ivona Mateska, Anke Witt, Eman Hagag, Anupam Sinha, Canelif Yilmaz, Evangelia Thanou, Na Sun, Ourania Kolliniati, Maria Patschin, Heba Abdelmegeed, Holger Henneicke, Waldemar Kanczkowski, Ben Wielockx, Christos Tsatsanis, Andreas Dahl, Axel Karl Walch, Ka Wan Li, Mirko Peitzsch, Triantafyllos Chavakis, Vasileia Ismini Alexaki
Publikováno v:
eLife, Vol 12 (2023)
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe infla
Externí odkaz:
https://doaj.org/article/d76bdfc84c5744ebb32985d191ed6174
Autor:
Suzanne S. M. Miedema, Merel O. Mol, Frank T. W. Koopmans, David C. Hondius, Pim van Nierop, Kevin Menden, Christina F. de Veij Mestdagh, Jeroen van Rooij, Andrea B. Ganz, Iryna Paliukhovich, Shamiram Melhem, Ka Wan Li, Henne Holstege, Patrizia Rizzu, Ronald E. van Kesteren, John C. van Swieten, Peter Heutink, August B. Smit
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteom
Externí odkaz:
https://doaj.org/article/3d65d481ed034fb3accf44dce1155278
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 15 (2023)
Externí odkaz:
https://doaj.org/article/270a577b2c9044ca9fb090dab55b3711
Autor:
Sang S. Seo, Susana R. Louros, Natasha Anstey, Miguel A. Gonzalez-Lozano, Callista B. Harper, Nicholas C. Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind, Ka Wan Li, Emily K. Osterweil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dysregulated protein synthesis is key contributor to Fragile X syndrome. Here the authors identify a relationship between ribosome expression and the translation of long mRNAs that contributes to synaptic weakening in a model of Fragile X syndrome.
Externí odkaz:
https://doaj.org/article/8ae6ea90e044406685e3c0bd724e960e
Publikováno v:
Cells, Vol 13, Iss 1, p 14 (2023)
GABAA receptors are the major inhibitory receptors in the brain. They are hetero-pentamers with a composition of predominantly two α, two β, and one γ or δ subunit. Of the six α subunit genes, the α5 subunit displays a limited spatial expressio
Externí odkaz:
https://doaj.org/article/d7f9b4d52a7645c69f1d564e94edeec5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract To date, few phenotypes have been described for Arabidopsis 14-3-3 mutants or the phenotypes showing the role of 14-3-3 in plant responding to abiotic stress. Although one member of the 14-3-3 protein family (14-3-3 omicron) was shown to be
Externí odkaz:
https://doaj.org/article/422ea2bb09aa456a92f563f8dd663682
Autor:
Christina F. de Veij Mestdagh, Jaap A. Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S. M. Miedema, Maaike Goris, Rolinka J. van der Loo, Guido Krenning, Ka Wan Li, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains larg
Externí odkaz:
https://doaj.org/article/79d911a2ec34496183b119acd53c6f51
Autor:
Evangelia Thanou, Frank Koopmans, Débora Pita-Illobre, Remco V. Klaassen, Berna Özer, Ioannis Charalampopoulos, August B. Smit, Ka Wan Li
Publikováno v:
Cells, Vol 12, Iss 9, p 1242 (2023)
Suspension TRAPping filter (sTRAP) is an attractive sample preparation method for proteomics studies. The sTRAP protocol uses 5% SDS that maximizes protein solubilization. Proteins are trapped on a borosilicate glass membrane filter, where SDS is sub
Externí odkaz:
https://doaj.org/article/b0fbe708443d4fff8cc1f3c1466bfdbb
Autor:
Stephanie D. Beekhuis-Hoekstra, Kyoko Watanabe, Josefin Werme, Christiaan A. de Leeuw, Iryna Paliukhovich, Ka Wan Li, Frank Koopmans, August B. Smit, Danielle Posthuma, Vivi M. Heine
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102512- (2021)
The use of induced pluripotent stem cells (iPSC) to model human complex diseases is gaining popularity as it allows investigation of human cells that are otherwise sparsely available. However, due to its laborious and cost intensive nature, iPSC rese
Externí odkaz:
https://doaj.org/article/17cd00d645064ceab99c936775f4a01d