Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ka Man V. Lai"'
Autor:
Ka Man V. Lai, Christopher M. Coleman, Kristen E. Pascal, Alejandro O. Mujica, Christos A. Kyratsous, Robert Babb, Vishal Kamat, Matthew B. Frieman, Ashok Badithe, Krystal Matthews, Neil Stahl, Charleen Hunt, Alexander Berrebi, Tammy T. Huang, Jeanne M. Sisk, Gang Chen, Jeanette L. Fairhurst, George D. Yancopoulos, William C. Olson, John Strein
Publikováno v:
Proceedings of the National Academy of Sciences
Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections hinders the in vivo testing of potential therapeutics. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55faf5193b385b5ba5dc08c6212c8d6
Autor:
Elizabeth J. Brown, Victoria T. Charoonratana, Fang Wang, Henry N. Higgs, Martin R. Pollak, Balajikarthick Subramanian, Hua Sun, Johannes Schlondorff, Paul Yan, Ka Man V Lai, David M. Valenzuela
Publikováno v:
Kidney international. 90(2)
Mutations in the INF2 (inverted formin 2) gene, encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause human focal segmental glomerulosclerosis (FSGS). INF2 interacts directly with certain other mammalian diapha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396359c76a32688b692053f489d83f3c
https://pubmed.ncbi.nlm.nih.gov/27350175
https://pubmed.ncbi.nlm.nih.gov/27350175
Autor:
Buckler David R, Charleen Hunt, Michael F. Murray, Jeffrey G. Reid, Jesper Gromada, Jesus A. Trejos, George D. Yancopoulos, Lukas Habegger, Aris Baras, Ingrid B. Borecki, Frederick E. Dewey, David J. Carey, Alan R. Shuldiner, David H. Ledbetter, John Penn, Andrew J. Murphy, Joseph B. Leader, Cristopher V. Van Hout, Omri Gottesman, Marylyn D. Ritchie, Colm O'Dushlaine, Alexander E. Lopez, Viktoria Gusarova, John D. Overton, Ka Man V. Lai, H. Lester Kirchner
Higher-than-normal levels of circulating triglycerides are a risk factor for ischemic cardiovascular disease. Activation of lipoprotein lipase, an enzyme that is inhibited by angiopoietin-like 4 (ANGPTL4), has been shown to reduce levels of circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2709df700f20f96ff853e7fb5a0f645e
https://europepmc.org/articles/PMC4900689/
https://europepmc.org/articles/PMC4900689/
Autor:
David J. Glass, George D. Yancopoulos, William O. Kline, Mark W. Sleeman, Karen Garcia, Katherine E. Wortley, Jennifer Kintner, Ka-Man V. Lai, Lori C. Gowen, Stanley J. Wiegand, Trevor Stitt
Publikováno v:
Nature Medicine. 11:199-205
Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death. In the previous study, the targeting construct left the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b215efee772a1ee775ea09e36a25447e
https://doi.org/10.1038/nm1178
https://doi.org/10.1038/nm1178
Autor:
Michael Gonzalez, Trevor Stitt, George D. Yancopoulos, William O. Kline, William Poueymirou, Elizabeth Zlotchenko, Erqian Na, Ka-Man V. Lai, Aris N. Economides, David J. Glass
Publikováno v:
Molecular and Cellular Biology. 24:9295-9304
Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of atrophy is to induce the pathways normally leading to skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04e8e240816880f2436aebb616f9c7d
https://doi.org/10.1128/mcb.24.21.9295-9304.2004
https://doi.org/10.1128/mcb.24.21.9295-9304.2004
Autor:
Helen H. Hobbs, Yongcheng Huang, Jesper Gromada, Eriks Smagris, Jonathan C. Cohen, Ka Man V. Lai, John Zhong Li, Soumik BasuRay
Publikováno v:
Hepatology (Baltimore, Md.). 61(1)
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3bfcdc5bcca79570f17572d31fb5f3
https://pubmed.ncbi.nlm.nih.gov/26206460
https://pubmed.ncbi.nlm.nih.gov/26206460