Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

Autor: Vicky Wang-Wei Tsai, Laurence Macia, Christine Feinle-Bisset, Rakesh Manandhar, Arne Astrup, Anne Raben, Janne Kunchel Lorenzen, Peter T Schmidt, Fredrik Wiklund, Nancy L Pedersen, Lesley Campbell, Adamandia Kriketos, Aimin Xu, Zhou Pengcheng, Weiping Jia, Paul M G Curmi, Christopher N Angstmann, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher P Marquis, Yasmin Husaini, Christoph Beglinger, Shu Lin, Herbert Herzog, David A Brown, Amanda Sainsbury, Samuel N Breit

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133362 (2015)

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct

Externí odkaz: https://doaj.org/article/737ad1ed5f8142afac832eb05e943fb9

TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

Autor: Vicky Wang-Wei Tsai, Laurence Macia, Heiko Johnen, Tamara Kuffner, Rakesh Manadhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Liyun Wu, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Herbert Herzog, David A Brown, Amanda Sainsbury, Samuel N Breit

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55174 (2013)

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels o

Externí odkaz: https://doaj.org/article/4ebdfbedb0784895822349eac65958ab

Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity

Autor: Hong Ping Zhang, Rakesh Manandhar, Helene Lebhar, Ka Ki Michelle Lee-Ng, Vicky Wang-Wei Tsai, Samuel N. Breit, Christopher P. Marquis, Yasmin Husaini, David Brown

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0233846 (2020)

Growth Differentiation Factor-15 (GDF15) is a divergent TGF-beta superfamily cytokine that is overexpressed by most cancers and is induced by anticancer therapy. Transgenic and induced animal models suggest that it protects from cancer development bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952d15a875dabcd218cb2dacd38ebd74
https://pubmed.ncbi.nlm.nih.gov/32502202

MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma

Autor: M L Thomas, David Brown, Natalia K. Botelho, Samuel N. Breit, Dan Falkenback, Reginald V. Lord, David C. Whiteman, Ka Ki Michelle Lee-Ng, Oliver M. Fisher, Yuri V. Bobryshev, Sarah J. Lord, A. J. M. Levert-Mignon

Publikováno v: British Journal of Cancer; 112(8), pp 1384-1391 (2015)
British Journal of Cancer

Background: Biomarkers are needed to improve current diagnosis and surveillance strategies for patients with Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). Macrophage inhibitory cytokine 1/growth differentiation factor 15 (MIC-1/GDF1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f083e0a5fff088fbd4639d3859e4e403
https://lup.lub.lu.se/record/5342032

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

Autor: Hong Ping Zhang, Ka Ki Michelle Lee-Ng, Samuel N. Breit, Aimin Xu, Adamandia D. Kriketos, Christine Feinle-Bisset, Shu Lin, Fredrik Wiklund, Paul M. G. Curmi, David Brown, Christopher P. Marquis, Laurence Macia, Christoph Beglinger, Herbert Herzog, Zhou Pengcheng, Arne Astrup, Rakesh Manandhar, Peter T. Schmidt, Yasmin Husaini, Nancy L. Pedersen, Janne K. Lorenzen, Christopher N. Angstmann, Weiping Jia, Vicky Wang-Wei Tsai, Amanda Sainsbury, Lesley V. Campbell, Anne Raben

Publikováno v: Europe PubMed Central
PLoS ONE
Tsai, V W-W, Macia, L, Feinle-Bisset, C, Manandhar, R, Astrup, A, Raben, A, Lorenzen, J K, Schmidt, P T, Wiklund, F, Pedersen, N L, Campbell, L, Kriketos, A, Xu, A, Pengcheng, Z, Jia, W, Curmi, P M G, Angstmann, C N, Lee-Ng, K K M, Zhang, H P, Marquis, C P, Husaini, Y, Beglinger, C, Lin, S, Herzog, H, Brown, D A, Sainsbury, A & Breit, S N 2015, ' Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI ', P L o S One, vol. 10, no. 7, e0133362 . https://doi.org/10.1371/journal.pone.0133362
PLoS ONE, Vol 10, Iss 7, p e0133362 (2015)

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59e0cde7773d207581a1bb97a5a5049
http://europepmc.org/abstract/med/26207898