Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ka Hyon Park"'
Autor:
Ji-Hyun Kim, Weon-Young Choi, Seung-Jun Jeong, Ka Hyon Park, Gyuseok Lee, Mangeun Kim, Soo-Chang Joo, Seongjun Kim, Beom-Jin Cho, Young-Ok Son, Je-Hwang Ryu
Publikováno v:
Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-12 (2024)
Abstract Periodontal disease presents a significant challenge in oral health due to its chronic inflammatory nature and subsequent degradation of tooth-supporting structures. Natural compounds have attracted attention for their potential therapeutic
Externí odkaz:
https://doaj.org/article/24f4bea643de4cf7b531712bb944d9ee
Autor:
Sun Young Lee, Su-Jin Kim, Ka Hyon Park, Gyuseok Lee, Youngsoo Oh, Je-Hwang Ryu, Yun Hyun Huh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Bone is a highly dynamic tissue undergoing continuous formation and resorption. Here, we investigated differential but complementary roles of hypoxia-inducible factor (HIF)-1α and HIF-2α in regulating bone remodeling. Using RNA-seq analysi
Externí odkaz:
https://doaj.org/article/aead2be3b597492993095c0c6cef9667
Autor:
Thanh-Tam Tran, Gyuseok Lee, Yun Hyun Huh, Ki-Ho Chung, Sun Young Lee, Ka Hyon Park, Seung Hee Kwon, Min-Suk Kook, Jang-Soo Chun, Jeong-Tae Koh, Je-Hwang Ryu
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 12, Pp 2553-2563 (2023)
Abstract Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this relationship is lacking, and the involvement of cholesterol metabolism in the pathogenesis of periodont
Externí odkaz:
https://doaj.org/article/158a32c49f144c138b57ec12c0cfbf54
Autor:
Je-Hwang Ryu, Sun Young Lee, Won-Hyun Song, Yun Hyun Huh, Seung-Hee Kwon, Jeong-Tae Koh, Ka Hyon Park, Gyuseok Lee, Su-Jin Kim
Publikováno v:
Experimental & Molecular Medicine
Aging is associated with cellular senescence followed by bone loss leading to bone fragility in humans. However, the regulators associated with cellular senescence in aged bones need to be identified. Hypoxia-inducible factor (HIF)−2α regulates bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52873226acd1f859ac77660f6d43db2
https://doi.org/10.1038/s12276-021-00594-y
https://doi.org/10.1038/s12276-021-00594-y
Autor:
Je-Yong Choi, Jeong-Tae Koh, Hyung-Gu Yu, Gyuseok Lee, Won-Hyun Song, Sun Young Lee, Hong-In Shin, Yun Hyun Huh, Je-Hwang Ryu, Ka Hyon Park, Eunbyul Kook
Publikováno v:
Bone Research
Bone Research, Vol 7, Iss 1, Pp 1-14 (2019)
Bone Research, Vol 7, Iss 1, Pp 1-14 (2019)
Pathological bone loss is caused by an imbalance between bone formation and resorption. The bone microenvironments are hypoxic, and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling. However, the relevant functions of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfb9db82a09ba5d57017eece9f3a777
http://europepmc.org/articles/PMC6513851
http://europepmc.org/articles/PMC6513851
Autor:
Song Yub Shin, Kyung-Soo Hahm, Jin-Kyoung Kim, Ju-Un Lee, Yoonkyung Park, Ka Hyon Park, Yangmee Kim, Jee-Young Lee
Publikováno v:
Bulletin of the Korean Chemical Society. 29:1190-1194
209-214]. Our previous study on AR-1 and its linearderivative showed that disulfide bridge and the amphipat hic â-sheet structure of the AR-1 play important rolesin their biological activities. AR-1 ha s high antibacterial activity but it also displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697680549c26f02de9fe7c0a42cd444e
https://doi.org/10.5012/bkcs.2008.29.6.1190
https://doi.org/10.5012/bkcs.2008.29.6.1190
Publikováno v:
Journal of Peptide Science. 14:876-882
To develop novel Pro-rich model AMPs with shorter length and higher bacterial selectivity/therapeutic index (TI) than natural AMP, indolicidin, we synthesized a series of undodecapeptides derived from the sequence XXPXXPWXPXX-NH2 (X indicates Leu or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f584371b73580523391199b17898f3
https://doi.org/10.1002/psc.1019
https://doi.org/10.1002/psc.1019
Autor:
Ka Hyon Park, Yong Hai Nan, Il-Seon Park, Yoonkyung Park, Kyung-Soo Hahm, Young Jin Jeon, Song Yub Shin
Publikováno v:
Protein & Peptide Letters. 14:1003-1007
To develop a novel cell-selective antimicrobial peptide with potent anti-inflammatory activity as well as high bacterial cell selectivity, we synthesized a Leu/Lys-rich model peptide, KLW-f (KWKKLLKKfLKLfKKLLK-NH(2)) containing two Phe-peptoid residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec52851e6d31c8c46055dd733b62ccd
https://doi.org/10.2174/092986607782541042
https://doi.org/10.2174/092986607782541042
Autor:
Song Yub Shin, Yun Mi Song, Yoonkyung Park, Il-Seon Park, Jae Il Kim, Ka Hyon Park, Sung-Tae Yang, Wan Long Zhu, Kyung-Soo Hahm
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768:1506-1517
Melittin (ME), a non-cell-selective antimicrobial peptide, contains the leucine zipper motif, wherein every seventh amino acid is leucine or isolucine. Here, we attempted to generate novel cell-selective peptides by substituting amino acids in the le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e055cad8a7578ae67cdd6401f53422a5
https://doi.org/10.1016/j.bbamem.2007.03.010
https://doi.org/10.1016/j.bbamem.2007.03.010
Autor:
Min-Suk Kook, Sun Hun Kim, Gyuseok Lee, Yunkyung Hong, Je-Hwang Ryu, Jeong Tae Koh, Duck Kyu Kim, Yun Hyun Huh, Jang-Soo Chun, Su Hyeon Lee, Shee Eun Lee, Ka Hyon Park
Publikováno v:
Experimental & Molecular Medicine
Periodontal disease is one of the most prevalent chronic disorders worldwide. It is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss. Here, we focused on the role of adipokines, which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6372aff6d4f334d5f91e3649a96353b9
https://doi.org/10.1038/emm.2017.116
https://doi.org/10.1038/emm.2017.116