Zobrazeno 1 - 10
of 4 381
pro vyhledávání: '"Ka Fai To"'
Autor:
Man Wu, Pok Man Hau, Linxian Li, Chi Man Tsang, Yike Yang, Aziz Taghbalout, Grace Tin-Yun Chung, Shin Yee Hui, Wing Chung Tang, Nathaniel Jillette, Jacqueline Jufen Zhu, Horace Hok Yeung Lee, Ee Ling Kong, Melissa Sue Ann Chan, Jason Ying Kuen Chan, Brigette Buig Yue Ma, Mei-Ru Chen, Charles Lee, Ka Fai To, Albert Wu Cheng, Kwok-Wai Lo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the lack of specific and efficient therapeutic agents to indu
Externí odkaz:
https://doaj.org/article/5ea7e874509d4bf389c2b2f00f71f2fc
Autor:
Bonan Chen, Peiyao Yu, Wai Nok Chan, Fuda Xie, Yigan Zhang, Li Liang, Kam Tong Leung, Kwok Wai Lo, Jun Yu, Gary M. K. Tse, Wei Kang, Ka Fai To
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-41 (2024)
Abstract Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellul
Externí odkaz:
https://doaj.org/article/09e92dfd5d834ba09b5bb3234a545c80
Autor:
Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To, Yangchao Chen
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effective therapies remain
Externí odkaz:
https://doaj.org/article/9389a1b3b2f84f64a6c66f954ca07751
Autor:
Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alvin H. K. Cheung, Raymond W. M. Lung, Chit Chow, Zhenhua Zhang, Canbin Fang, Peiyao Yu, Shihua Shi, Shikun Zhou, Guoming Chen, Zhangding Wang, Shouyu Wang, Xiaofan Ding, Bing Huang, Li Liang, Yujuan Dong, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Nathalie Wong, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Wei Kang, Ka Fai To
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions. Their inherent phenotypic and functional di
Externí odkaz:
https://doaj.org/article/9cd923a1d35b477fa1d0c64190bf7e15
Autor:
Bei Huang, Steven W. H. Chau, Yaping Liu, Joey W. Y. Chan, Jing Wang, Suk Ling Ma, Jihui Zhang, Paul K. S. Chan, Yun Kit Yeoh, Zigui Chen, Li Zhou, Sunny Hei Wong, Vincent C. T. Mok, Ka Fai To, Hei Ming Lai, Simon Ng, Claudia Trenkwalder, Francis K. L. Chan, Yun Kwok Wing
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree re
Externí odkaz:
https://doaj.org/article/c3bbdd259c714201900d6ae7b4f3e793
Autor:
Bonan Chen, Xiaoli Liu, Peiyao Yu, Fuda Xie, Johnny S. H. Kwan, Wai Nok Chan, Canbin Fang, Jinglin Zhang, Alvin H. K. Cheung, Chit Chow, Gloria W. M. Leung, Kam Tong Leung, Shihua Shi, Bin Zhang, Shouyu Wang, Dazhi Xu, Kaili Fu, Chi Chun Wong, William K. K. Wu, Michael W. Y. Chan, Patrick M. K. Tang, Chi Man Tsang, Kwok Wai Lo, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background Gastric cancer (GC) is one of the most common tumours in East Asia countries and is associated with Helicobacter pylori infection. H. pylori utilizes virulence factors, CagA and VacA, to up‐regulate pro‐inflammatory cytokines
Externí odkaz:
https://doaj.org/article/7bfa61a822b64b09a39959da5d928f18
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 3, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/1d8ccae8dff047db8893ef0085f000a1
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 3, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/13735357856741d5a24d3aecc570e273
Autor:
Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic targ
Externí odkaz:
https://doaj.org/article/b983ec1445e54ade901f9b1e5f30d6ee
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 2, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/15f2377cd531424c867af68e4e137988