Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ka Cheong Lee"'
Autor:
Catriona M. Manville, Kayleigh Smith, Zbyslaw Sondka, Holly Rance, Simon Cockell, Ian G. Cowell, Ka Cheong Lee, Nicholas J. Morris, Kay Padget, Graham H. Jackson, Caroline A. Austin
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1436-1447 (2015)
We report the whole genome ChIP seq for human TOP2B from MCF7 cells. Using three different peak calling methods, regions of binding were identified in the presence or absence of the nuclear hormone estradiol, as TOP2B has been reported to play a role
Externí odkaz:
https://doaj.org/article/055315db40254aaea064d00951d4fe25
Autor:
Ka Cheong Lee, Kay Padget, Hannah Curtis, Ian G. Cowell, Davide Moiani, Zbyslaw Sondka, Nicholas J. Morris, Graham H. Jackson, Simon J. Cockell, John A. Tainer, Caroline A. Austin
Publikováno v:
Biology Open, Vol 1, Iss 9, Pp 863-873 (2012)
Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions
Externí odkaz:
https://doaj.org/article/c1789a07de1448d3ab9e218b1af5e122
Autor:
Ka Cheong Lee, Rebecca L. Swan, Zbyslaw Sondka, Kay Padget, Ian G. Cowell, Caroline A. Austin
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2056 (2018)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5′-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilisin
Externí odkaz:
https://doaj.org/article/a01a595025de4fa4b731de81b19ea60d
Autor:
Kay Padget, Ian G. Cowell, Ka Cheong Lee, Rebecca L. Swan, Caroline A. Austin, Zbyslaw Sondka
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2056 (2018)
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2056 (2018)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5′-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb0d6af4d44506da4830341dcdf9b0c
Autor:
Graham Jackson, Zbyslaw Sondka, Simon Cockell, Kay Padget, Caroline A. Austin, Holly Ashlene Rance, Catriona Manville, Kayleigh A. Smith, Ka Cheong Lee, Nicholas J. Morris, Ian G. Cowell
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1436-1447 (2015)
Biology Open
Biology Open
We report the whole genome ChIP seq for human TOP2B from MCF7 cells. Using three different peak calling methods, regions of binding were identified in the presence or absence of the nuclear hormone estradiol, as TOP2B has been reported to play a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439070e5fc3cec5ed444e93fc575e278
http://bio.biologists.org/content/4/11/1436
http://bio.biologists.org/content/4/11/1436
Autor:
Kay Padget, Ian G. Cowell, Caroline A. Austin, John A. Tainer, Hannah Curtis, Simon Cockell, Zbyslaw Sondka, Ka Cheong Lee, Graham Jackson, Nicholas J. Morris, Davide Moiani
Publikováno v:
Biology Open, Vol 1, Iss 9, Pp 863-873 (2012)
Biology Open
Biology Open
Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 59phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2f51e989c705c9e97fadbc95ba71d2
http://bio.biologists.org/content/1/9/863
http://bio.biologists.org/content/1/9/863
Autor:
Ian G. Cowell, Catriona Manville, Graham Jackson, Noritaka Adachi, Malgorzata Sidorczuk-Lesthuruge, Ka Cheong Lee, Caroline A. Austin, Kayleigh A. Smith, Kay Padget, Zbyslaw Sondka, Holly Ashlene Rance
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8989-8994
Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective cytotoxic anticancer agents. However, they are associated with the development of therapy-related acute myeloid leukemias (t-AMLs), which display characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebe5aaebf76068007352aa136ce7182
https://doi.org/10.1073/pnas.1204406109
https://doi.org/10.1073/pnas.1204406109
Autor:
Cowella, Ian G., Sondka, Zbyslaw, Smith, Kayleigh, Ka Cheong Lee, Manville, Catriona M., Sidorczuk-Lesthuruge, Malgorzata, Rance, Holly Ashlene, Padget, Kay, Jackson, Graham Hunter, Adachi, Noritaka, Austin, Caroline A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/5/2012, Vol. 109 Issue 23, p8989-8994, 6p