Zobrazeno 1 - 10
of 4 371
pro vyhledávání: '"Ka‐Fai To"'
Autor:
Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS
Publikováno v:
JTO Clinical and Research Reports, Vol 6, Iss 1, Pp 100754- (2025)
Introduction: The germline human leukocyte antigen (HLA) status has been found to be associated with immunotherapy outcomes in patients with NSCLC, but its correlation to immunotherapy-induced pneumonitis and prognostic impact in the Asian population
Externí odkaz:
https://doaj.org/article/059884a272f345c18d1c55e8ba3a0eda
Autor:
Xiaoyu Liu, Man Liu, Haoran Wu, Wenshu Tang, Weiqin Yang, Thomas T.H. Chan, Lingyun Zhang, Shufen Chen, Zhewen Xiong, Jianxin Liang, Willis Wai-Yiu Si-Tou, Ting Shu, Jingqing Li, Jianquan Cao, Chengpeng Zhong, Hanyong Sun, Tsz Tung Kwong, Howard H.W. Leung, John Wong, Paul Bo-San Lai, Ka-Fai To, Tingxiu Xiang, Joseph Jao-Yiu Sung, Stephen Lam Chan, Jingying Zhou, Alfred Sze-Lok Cheng
Publikováno v:
JHEP Reports, Vol 6, Iss 7, Pp 101087- (2024)
Background & Aims: Recent studies demonstrated the importance of fibrosis in promoting an immunosuppressive liver microenvironment and thereby aggressive hepatocellular carcinoma (HCC) growth and resistance to immune checkpoint blockade (ICB), partic
Externí odkaz:
https://doaj.org/article/548a0fa4c9c849b8b8cb170ca38dbeaf
Autor:
Ryan Tsz‐Hei Tse, Christine Yim‐Ping Wong, Xiaofan Ding, Carol Ka‐Lo Cheng, Chit Chow, Ronald Cheong‐Kin Chan, Joshua Hoi‐Yan Ng, Victor Wai‐Lun Tang, Peter Ka‐Fung Chiu, Jeremy Yuen‐Chun Teoh, Nathalie Wong, Ka‐Fai To, Chi‐Fai Ng
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Introduction Kidney cancer is a common urological malignancy worldwide with an increasing incidence in recent years. Among all subtypes, renal cell carcinoma (RCC) represents the most predominant malignancy in kidney. Clinicians faced a majo
Externí odkaz:
https://doaj.org/article/8568ecb3f89e4e14bb1fd30b5680afa0
Autor:
Jane Siu-Fan Li, Philip Chiu-Tsun Tang, Chun Kit K. Choi, Alex Siu-Wing Chan, Calvin Sze-Hang Ng, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102823- (2024)
Summary: Immunodynamics in the tumor microenvironment can be precisely examined by using multiple antigen identification approaches. Here, we present a protocol for capturing expression levels of multiple target proteins in the same specimen at singl
Externí odkaz:
https://doaj.org/article/cd4afc4f3ab7487fb859f4714d8f1397
Autor:
Alvin Ho-Kwan Cheung, Kit-Yee Wong, Xiaoli Liu, Fenfen Ji, Chris Ho-Lam Hui, Yihan Zhang, Johnny Sheung-Him Kwan, Bonan Chen, Yujuan Dong, Raymond Wai-Ming Lung, Jun Yu, Kwok Wai Lo, Chi Chun Wong, Wei Kang, Ka-Fai To
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-14 (2023)
Abstract MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progression. However, its role in lung adenocarcinoma has not been characterized. Here, we showed that MLK4 was overexpressed
Externí odkaz:
https://doaj.org/article/1fab759148bb485a803a9fe5b39656cf
Autor:
Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Jeff Yat‐Fai Chung, Alex Siu‐Wing Chan, Dongmei Zhang, Chunjie Li, Kam‐Tong Leung, Calvin Sze‐Hang Ng, Yi Wu, Ka‐Fai To, Hui‐Yao Lan, Patrick Ming‐Kuen Tang
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung carcinoma (NSCLC) in a TGF‐β1/Smad3 dependent manner. Better un
Externí odkaz:
https://doaj.org/article/87ee915054aa49ad8d44d285ae662e18
Autor:
Max Kam-Kwan Chan, Emily Lok-Yiu Chan, Zoey Zeyuan Ji, Alex Siu-Wing Chan, Chunjie Li, Kam-Tong Leung, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 2, Pp 316-343 (2023)
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, b
Externí odkaz:
https://doaj.org/article/f66b695eb39a44d683eec8cd54acc160
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and anti-cancer activities are reported, including not only angiogenesis, extra
Externí odkaz:
https://doaj.org/article/a52ec436a9d74b35b7278bb97071615b
Autor:
Chi Hin Wong, Ut Kei Lou, Frederic Khe-Cheong Fung, Joanna H. M. Tong, Chang-hua Zhang, Ka-Fai To, Stephen Lam Chan, Yangchao Chen
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Circular RNAs (circRNAs) play important roles in many biological processes. However, the detailed mechanism underlying the critical roles of circRNAs in cancer remains largely unexplored. We aim to explore the molecular mechanisms
Externí odkaz:
https://doaj.org/article/0809fdecbc0a4741a5ee9cfc386e59c8