Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ka Fai Suen"'
Publikováno v:
Pflügers Archiv, Vol. 450, No 1 (2005) pp. 61-73
The coupling of GABA(B) receptors to G-protein-gated inwardly rectifying potassium (GIRK) channels constitutes an important inhibitory pathway in the brain. Here, we examined the mechanism underlying desensitization of agonist-evoked currents carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc701924da2791617da23a262c4185c
http://doc.rero.ch/record/318739/files/424_2004_Article_1367.pdf
http://doc.rero.ch/record/318739/files/424_2004_Article_1367.pdf
Autor:
Jennifer L. Harris, Christine Tumanut, Glen Spraggon, Gene Liau, Eric Hampton, Rachelle Tumanut, Scott A. Lesley, John Trauger, David Yowe, Julie-Ann Gavigan, Waan-Jeng Huang, Jun Li, Ka Fai Suen
Publikováno v:
Biochemical Journal. 406:203-207
PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a672502076628c7d9f90639f6c0c2e95
https://doi.org/10.1042/bj20070664
https://doi.org/10.1042/bj20070664
Publikováno v:
The Journal of Physiology. 580:51-65
Many neurotransmitters and hormones signal by stimulating G protein-coupled neurotransmitter receptors (GPCRs), which activate G proteins and their downstream effectors. Whether these signalling proteins diffuse freely within the plasma membrane is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d2ad6edcdbc81beaf1d035443df1b0
https://doi.org/10.1113/jphysiol.2006.123216
https://doi.org/10.1113/jphysiol.2006.123216
Publikováno v:
Journal of Biological Chemistry. 279:28149-28158
Ligand-gated ion channel receptors mediate the response of fast neurotransmitters by opening in less than a millisecond. Here, we investigated the activation mechanism of a serotonin-gated receptor (5-HT3A) by systematically introducing cysteine subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65e07c5182083756e897ec7239c4ddb
https://doi.org/10.1074/jbc.m403545200
https://doi.org/10.1074/jbc.m403545200
Publikováno v:
The Journal of Physiology. 555:643-657
The activity of G protein-activated inwardly rectifying K+ channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although Gβγ subunits are known to bind the N- and C-termini of GIRK chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43be7f6d3a72cf0ee82cb319e11d5ca3
https://doi.org/10.1113/jphysiol.2003.056101
https://doi.org/10.1113/jphysiol.2003.056101
Autor:
Michael Eckart, Bo Liu, Masao Yamada, Jennifer L. Harris, Weijia Ou, Anthony Slavin, Mary S. Turner, Elizabeth Zuo, Feng Gao, Tove Tuntland, Alana Althage, Tomohisa Ogawa, John Trauger, Ka Fai Suen
Publikováno v:
Protein expression and purification. 71(1)
Transient transfection of mammalian cells in suspension culture has recently emerged as a very useful method for production of research-scale quantities of recombinant proteins. The most commonly used cell lines for this purpose are suspension-adapte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341cbca456571c928dae793964376ec5
https://pubmed.ncbi.nlm.nih.gov/20045465
https://pubmed.ncbi.nlm.nih.gov/20045465
Autor:
Sinead M. Clancy, Melissa Finley, Frédérique Berton, Christine Arrabit, Patrick J. Casey, Paul A. Slesinger, Tohru Kosaza, Catherine E. Fowler, Ka Fai Suen
Publikováno v:
Molecular and cellular neurosciences. 28(2)
Neuronal G-protein-gated inwardly rectifying potassium (Kir3; GIRK) channels are activated by G-protein-coupled receptors that selectively interact with PTX-sensitive (Galphai/o) G proteins. Although the Gbetagamma dimer is known to activate GIRK cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b23175bd7b6f1468e7f6daaeaac1948
https://pubmed.ncbi.nlm.nih.gov/15691717
https://pubmed.ncbi.nlm.nih.gov/15691717
Publikováno v:
The Journal of physiology. 555(Pt 3)
The activity of G protein-activated inwardly rectifying K(+) channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although G(betagamma) subunits are known to bind the N- and C-termini of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2498420a359f717830561ef2ae767595
https://pubmed.ncbi.nlm.nih.gov/14724209
https://pubmed.ncbi.nlm.nih.gov/14724209
Autor:
Jun Li, Christine Tumanut, Julie-Ann Gavigan, Waan-Jeng Huang, Eric N. Hampton, Rachelle Tumanut, Ka Fai Suen, John W. Trauger, Glen Spraggon, Scott A. Lesley, Gene Liau, David Yowe, Jennifer L. Harris
Publikováno v:
Biochemical Journal; 2007, Vol. 406 Issue 2, p203-207, 5p
Publikováno v:
Pflügers Archiv: European Journal of Physiology; Apr2005, Vol. 450 Issue 1, p61-73, 13p