OP0004 Pivotal role for the small gtpase rap1 in the regulation of intracellular generated ros after t cell stimulation

Autor: JM VanLaar, Ferdinand C. Breedveld, KA Reedquist, CL Verweij, SI Gringhuis, Phj Remans

Publikováno v: Speaker abstracts 2001.

Background Oxidative stress plays a critical role in various diseases including cancer, neuronal degeneration, atherosclerosis and rheumatoid arthritis. Identifying the target proteins for redox modification is crucial in understanding how oxidants m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cae5b76b3fcb2a859e8a2ed00d433c82
https://doi.org/10.1136/annrheumdis-2001.518

HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients.

Autor: Martínez-Ramos S; Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain., Rafael-Vidal C; Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain., Malvar-Fernández B; Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain., Rodriguez-Trillo A; Laboratorio de Reumatología Experimental y Observacional, Servicio de Reumatología, Instituto de Investigación Sanitaria de Santiago (IDIS), Hospital Clínico, Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain., Veale D; Rheumatology EULAR Centre of Excellence, St Vincent's University Hospital and University College Dublin, Dublin, Ireland., Fearon U; Rheumatology EULAR Centre of Excellence, St Vincent's University Hospital and University College Dublin, Dublin, Ireland.; Department of Molecular Rheumatology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland., Conde C; Laboratorio de Reumatología Experimental y Observacional, Servicio de Reumatología, Instituto de Investigación Sanitaria de Santiago (IDIS), Hospital Clínico, Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain., Conde-Aranda J; Molecular and Cellular Gastroenterology, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Radstake TRDJ; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Pego-Reigosa JM; Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain., Reedquist KA; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., García S; Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Jul 05; Vol. 62 (7), pp. 2621-2630.

Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.

Autor: Ottria A; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Zimmermann M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Paardekooper LM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Carvalheiro T; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Vazirpanah N; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Silva-Cardoso S; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Affandi AJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Chouri E; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., V D Kroef M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Tieland RG; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Bekker CPJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Wichers CGK; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Rossato M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Mocholi-Gimeno E; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Tekstra J; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Ton E; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., van Laar JM; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Cossu M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Beretta L; Referral Center for Systemic Autoimmune Diseases, University of Milan & Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy., Garcia Perez S; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Pandit A; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Bonte-Mineur F; Department of Rheumatology and Clinical Immunology, Maasstad Hospital, Rotterdam., Reedquist KA; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., van den Bogaart G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands., Radstake TRDJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Marut W; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 May 30; Vol. 61 (6), pp. 2682-2693.

cDC1 are required for the initiation of collagen-induced arthritis.

Autor: Ramos MI; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands., Garcia S; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands., Helder B; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands., Aarrass S; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands., Reedquist KA; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands., Jacobsen SE; Haematopoietic Stem Cell Laboratory and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Tak PP; Department of Clinical Immunology and Rheumatology., Lebre MC; Department of Clinical Immunology and Rheumatology.; Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2020 Sep 16; Vol. 3, pp. 100066. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).

Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients.

Autor: Kabala PA; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Malvar-Fernández B; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Lopes AP; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Carvalheiro T; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Hartgring SAY; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Tang MW; Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, The Netherlands., Conde C; Laboratorio de Investigación 8 y Servicio de Reumatología, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Spain., Baeten DL; Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, The Netherlands., Sleeman M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA., Tak PP; Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, The Netherlands.; GlaxoSmithKline, Stevenage.; Department of Medicine, University of Cambridge, Cambridge, UK., Connor J; MedImmune LCC, MD, USA., Radstake TR; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., Reedquist KA; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht., García S; Department of Rheumatology and Clinical Immunology, University of Utrecht, Utrecht.; Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Feb 01; Vol. 59 (2), pp. 426-438.