Modi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers.

Autor: Al-Omari AA; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Cook KW; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Symonds P; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Skinner A; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Wright A; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Zhu Y; Barinthus Biotherapeutics North America, Inc; 20400 Century Blvd, Suite 210, Germantown, MD, 20874, USA., Coble VL; Barinthus Biotherapeutics North America, Inc; 20400 Century Blvd, Suite 210, Germantown, MD, 20874, USA., Mohammed OJ; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Choudhury RH; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Uddin N; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Ranglani P; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Parry A; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Adams SE; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK., Lynn GM; Barinthus Biotherapeutics North America, Inc; 20400 Century Blvd, Suite 210, Germantown, MD, 20874, USA., Durrant LG; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK. lindydurrant@scancell.co.uk., Brentville VA; Scancell Ltd; Bellhouse Building, Sanders Road, Oxford Science Park, Oxford, OX4 4GD, UK.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Nov 27; Vol. 9 (1), pp. 236. Date of Electronic Publication: 2024 Nov 27.

Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool.

Autor: Choudhury RH; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Daniels I; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Vaghela P; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Atabani S; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK., Kirk T; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Symonds P; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Cook KW; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Al-Omari A; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Weston D; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Shah S; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Hutchinson D; Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Paston SJ; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Metheringham RL; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Brentville VA; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK., Durrant LG; Scancell Limited, University of Nottingham Biodiscovery Institute, Nottingham, UK.; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.

Publikováno v: Immunology [Immunology] 2023 Aug; Vol. 169 (4), pp. 467-486. Date of Electronic Publication: 2023 Apr 13.

Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy.

Autor: Brentville VA; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Symonds P; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Chua J; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Skinner A; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Daniels I; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Cook KW; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Koncarevic S; Proteome Sciences R & D GmbH & Co.KG, Frankfurt-am-Main, Germany., Martinez-Pinna R; Proteome Sciences R & D GmbH & Co.KG, Frankfurt-am-Main, Germany., Shah S; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Choudhury RH; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Vaghela P; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Weston D; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Al-Omari A; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Davis J; Division of Cancer and Stem Cells, Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom., Durrant LG; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.; Division of Cancer and Stem Cells, Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Dec 05; Vol. 13, pp. 1066185. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2022).

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses.

Autor: Symonds P; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Marcu A; Department of Immunology, Interfaculty Institute for Cell Biology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumour Therapies', University of Tübingen, Tübingen, Germany., Cook KW; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Metheringham RL; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Durrant LG; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.; Biodiscovery Institute, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, United Kingdom., Brentville VA; Scancell Limited, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Nov 09; Vol. 12, pp. 764462. Date of Electronic Publication: 2021 Nov 09 (Print Publication: 2021).

Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses.

Autor: Brentville VA; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Metheringham RL; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Daniels I; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Atabani S; Biodiscovery Institute, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK., Symonds P; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Cook KW; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Vankemmelbeke M; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Choudhury R; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Vaghela P; Biodiscovery Institute, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK., Gijon M; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK., Meiners G; ISA Pharmaceuticals, Leiden, The Netherlands., Krebber WJ; ISA Pharmaceuticals, Leiden, The Netherlands., Melief CJM; ISA Pharmaceuticals, Leiden, The Netherlands.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands., Durrant LG; Scancell Ltd, University of Nottingham Biodiscovery Institute, Nottingham, UK lindy.durrant@nottingham.ac.uk.; Biodiscovery Institute, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Jun; Vol. 8 (1).