IL‐6 signaling pathway contributes to exercise pressor reflex in rats with femoral artery occlusion in association with Kv4 activity in muscle afferent nerves

Autor: Qin Li, Lu Qin, Jianhua Li

Publikováno v: Physiological Reports, Vol 9, Iss 13, Pp n/a-n/a (2021)

Abstract Interleukin‐6 (IL‐6) via trans‐signaling pathway plays a role in modifying muscle sensory nerve‐exaggerated exercise pressor reflex in rats with ligated femoral arteries, but the underlying mechanisms are poorly understood. It is kno

Externí odkaz: https://doaj.org/article/d1a2244e224844939be90a16bff2249e

Modulation of K(V)4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

Autor: Angela de Benito-Bueno, Paula G. Socuellamos, Yaiza G. Merinero, Pilar Cercos, Carolina Izquierdo, Miguel Daniel-Mozo, Irene Marín-Olivero, Angel Perez-Lara, Juan A. Gonzalez-Vera, Angel Orte, Armando Albert, Mercedes Martin-Martinez, Marta Gutierrez-Rodriguez, Carmen Valenzuela

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9170
International Journal of Molecular Sciences
Digital.CSIC. Repositorio Institucional del CSIC
instname

The transient outward potassium current (Itof) is generated by the activation of KV4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f180e327b6c81f4e01fef6de03f7ab

Variation of Two S3b Residues in KV4.1–4.3 Channels Underlies Their Different Modulations by Spider Toxin κ-LhTx-1

Autor: Piao Zhao, Xiangyue Wu, Cheng Tang, Zhonghua Liu, Songping Liang, Zhen Xiao, Xiangjin Kong, Ruiwen Wang

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

The naturally occurred peptide toxins from animal venoms are valuable pharmacological tools in exploring the structure-function relationships of ion channels. Herein we have identified the peptide toxin κ-LhTx-1 from the venom of spider Pandercetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de221b8999603c29f5eb1c5fe53bde38
http://europepmc.org/articles/PMC8222713

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KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling

Autor: Julieta Palomeque, Charlotte Morel, Roger Kaprielian, Roger J. Hajjar, Djamel Lebeche, Ioannis Karakikes, Lahouaria Hadri, Hongwei Jin

Publikováno v: Journal of Molecular and Cellular Cardiology. 48:1169-1179

Recent evidence shows that the auxiliary subunit KChIP2, which assembles with pore-forming Kv4-subunits, represents a new potential regulator of the cardiac calcium-independent transient outward potassium current ( I to ) density. In hypertrophy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214b9f1dc3a1b1520ebf8a9c4ae08be9
https://doi.org/10.1016/j.yjmcc.2009.12.019