Rationale for a conditional knockout mouse model to study carnitine palmitoyltransferase I deficiencies

Autor: van der Leij, FR, Drijfholt, A, Kuipers, JRG, Quant, PA, Eaton, S

Publikováno v: CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS, 377-385
STARTPAGE=377;ENDPAGE=385;TITLE=CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS

Several severe congenital cardiomyopathies are known to be associated with deficiencies in long-chain fatty acid transport and oxidation. Our studies are focused on a key enzyme in the regulation of intracellular long-chain fatty acid transport: carn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5553dd6a238e807910ca30d886c46298
https://research.rug.nl/en/publications/1e91662f-4f95-4aed-9630-96c745f41b02

Determination of organ substrate oxidation in vivo by measurement of (CO2)-C-13 concentration in blood

Autor: Beaufort-Krol, GCM, Takens, J, Molenkamp, MC, Smid, GB, Zijlstra, WG, Kuipers, JRG

Publikováno v: Journal of Mass Spectrometry, 33(4), 328-333. Wiley

Substrate oxidation by various organs in animals as web is in humans is usually studied by experiments in which radioactively labeled substrates Pre used and the production of (CO2)-C-14 is measured In vivo, substrate oxidation by an organ has, up to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1c74d2f6504ef3899bc1a50b022dc00c
https://research.rug.nl/en/publications/ea5405f9-c8f8-4814-a227-e278ff8a8949

EFFECT OF INCREASED WHOLE-BLOOD VISCOSITY ON REGIONAL BLOOD FLOWS IN CHRONICALLY HYPOXEMIC LAMBS

Autor: DALINGHAUS, M, KNOESTER, H, GRATAMA, JWC, VANDERMEER, J, ZIJLSTRA, WG, KUIPERS, JRG

Publikováno v: American Journal of Physiology, 267(2), H471-H476

In chronic hypoxemia blood flow and oxygen supply to vital organs are maintained, but to nonvital organs they are decreased. We measured organ blood flows (microspheres) and whole blood viscosity in 10 chronically hypoxemic lambs, with an atrial sept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8c55c81e6064b4babb59908ed8db4d4a
https://research.rug.nl/en/publications/793e4b99-9994-468f-8fe1-73b452a789c3

BLOOD-VOLUME AND BODY-FLUID COMPARTMENTS IN LAMBS WITH AORTOPULMONARY LEFT-TO-RIGHT SHUNTS

Autor: GRATAMA, JWC, DALINGHAUS, M, MEUZELAAR, JJ, GERDING, AM, KOERS, JH, ZIJLSTRA, WG, KUIPERS, JRG

Publikováno v: The Journal of Clinical Investigation, 90(5), 1745-1752. AMER SOC CLINICAL INVESTIGATION INC

A left-to-right shunt is accompanied by an increased plasma and blood volume. Since this is likely realized through renin/aldosterone-mediated salt and water retention, other body fluid compartments may be changed too. Therefore, we studied blood vol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e170b6aab0ef181b83c99e3984a0e004
https://research.rug.nl/en/publications/f4ef2979-abbe-42b9-bcde-89724ce79698

MYOCARDIAL CARBOHYDRATE, KETONE, AND FATTY-ACID UPTAKE IN CONSCIOUS LAMBS WITH AORTOPULMONARY SHUNTS

Autor: GRATAMA, JWC, DALINGHAUS, M, MEUZELAAR, JJ, GERDING, AM, KOERS, JH, MUSKIET, FAJ, KUIPERS, JRG

Publikováno v: Pediatric Research, 32(1), 27-32. Nature Publishing Group

A left to right shunt increases myocardial work and is often accompanied by increased catecholamine levels. Because both increased myocardial work and increased catecholamine levels may induce increased fatty acid utilization, which could increase re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ec954d512b55d1ab76581d3e89604daf
https://research.rug.nl/en/publications/9d54f460-9006-4079-8ead-a5a65ae718c9