Studies on the site and mechanism of action of phenformin. I. Evidence for significant 'nonperipheral' effects of phenformin on glucose metabolism in normal subjects

Autor: Hollobaugh Sl, Rao Mb, Kruger Fa

Publikováno v: Diabetes. 19(1)

Oral and intravenous glucose tolerance tests were performed in ten normal subjects. Phenformin pretreatment flattened the glucose and insulin response to oral glucose loading but did not significantly alter the response to intravenous glucose. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a616e9bcb723a8799e5fd8d28637bdce
https://pubmed.ncbi.nlm.nih.gov/5410101

Structural and Functional View of Polypharmacology.

Autor: Moya-García A; University College London, Institute of Structural and Molecular Biology, London, UK. aurelio.moya@ucl.ac.uk.; Department of Molecular Biology and Biochemistry, Universidad de Malaga, 29071, Málaga Spain, CIBER de Enfermedades Raras (CIBERER), 29071, Málaga, Spain. aurelio.moya@ucl.ac.uk., Adeyelu T; University College London, Institute of Structural and Molecular Biology, London, UK., Kruger FA; European Molecular Laboratory - European Bioinformatics Institute, Hinxton, UK.; BenevolentAI, Churchway 40, NW1 1LW, London, UK., Dawson NL; University College London, Institute of Structural and Molecular Biology, London, UK., Lees JG; University College London, Institute of Structural and Molecular Biology, London, UK., Overington JP; European Molecular Laboratory - European Bioinformatics Institute, Hinxton, UK.; Medicines Discovery Catapult, Mereside, Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK., Orengo C; University College London, Institute of Structural and Molecular Biology, London, UK., Ranea JAG; Department of Molecular Biology and Biochemistry, Universidad de Málaga, 29071, Málaga, Spain.; CIBER de Enfermedades Raras (CIBERER), 29071, Málaga, Spain.

Publikováno v: Scientific reports [Sci Rep] 2017 Aug 31; Vol. 7 (1), pp. 10102. Date of Electronic Publication: 2017 Aug 31.

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

Autor: White J; UCL Genetics Institute, University College, London, UK. Electronic address: jon.white@ucl.ac.uk., Sofat R; Centre for Clinical Pharmacology, University College London, London, UK., Hemani G; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Shah T; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK., Engmann J; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK., Dale C; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Shah S; Queensland Brain Institute, University of Queensland, QLD, Australia., Kruger FA; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK., Giambartolomei C; UCL Genetics Institute, University College, London, UK., Swerdlow DI; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK., Palmer T; Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Langenberg C; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Zabaneh D; UCL Genetics Institute, University College, London, UK., Lovering R; Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, University College London, London, UK., Cavadino A; Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UnK., Jefferis B; Department of Primary Care & Population Health, University College London, Royal Free Campus, London, UK., Finan C; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Amuzu A; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Ong K; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Gaunt TR; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK., Warren H; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Denstistry, Queen Mary University of London, London, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Davies TL; School of Social and Community Medicine, University of Bristol, Bristol, UK., Drenos F; Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, University College London, London, UK; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Cooper J; Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, University College London, London, UK., Ebrahim S; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Lawlor DA; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Talmud PJ; Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, University College London, London, UK., Humphries SE; Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, University College London, London, UK., Power C; Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UnK., Hypponen E; Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UnK; School of Population Health and Sansom Institute of Health Research, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Richards M; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Hardy R; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Wareham N; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ben-Shlomo Y; School of Social and Community Medicine, University of Bristol, Bristol, UK., Day IN; School of Social and Community Medicine, University of Bristol, Bristol, UK., Whincup P; Population Health Research Institute, St George's, University of London, London, UK., Morris R; Department of Primary Care & Population Health, University College London, Royal Free Campus, London, UK., Strachan MW; Metabolic Unit, Western General Hospital, Edinburgh, UK., Price J; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Kivimaki M; Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK., Plagnol V; UCL Genetics Institute, University College, London, UK., Whittaker JC; Genetics Division, Research and Development, GlaxoSmithKline, Harlow, UK., Smith GD; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Dudbridge F; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Casas JP; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK., Holmes MV; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Surgery and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michael.holmes@ndph.ox.ac.uk., Hingorani AD; Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.

Publikováno v: The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2016 Apr; Vol. 4 (4), pp. 327-36. Date of Electronic Publication: 2016 Jan 16.

Mapping small molecule binding data to structural domains.

Autor: Kruger FA; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Rostom R, Overington JP

Publikováno v: BMC bioinformatics [BMC Bioinformatics] 2012; Vol. 13 Suppl 17, pp. S11. Date of Electronic Publication: 2012 Dec 13.

RNA polymerases in isolated rat heart nuclei and their response to cyclic nucleotides.

Autor: Nesher R, Robinson WF, Gibb L, Bishop SP, Kruger FA

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 1977 Jul; Vol. 9 (7), pp. 579-93.