Výsledky vyhledávání - "KRISTIAN SASS-ØRUM"

1292-P: Differential Glycaemic Effects of Recombinant IL-9 across Species Highlight Translational Challenges for Immunometabolic Phenotypes

Autor: TINGQING GUO, ELLEN MARIE STRAARUP, JOSEFINE LINDROOS CHRISTENSEN, GERT BOLT, PEDER LISBY NØRBY, WANG ZHE, THOMAS A. PEDERSEN, MERCEDES FERRERAS, KRISTIAN SASS-ØRUM, KLAUS S. FREDERIKSEN

Publikováno v: Diabetes. 71

In the present study, IL-9 was initially identified as a strong regulator of blood glucose in diabetic db/db mice through a hydrodynamic gene delivery screening effort. IL-9 belongs to the common gamma-chain binding cytokine family and has classicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77a0b625372f94c6f423e4743af3458a
https://doi.org/10.2337/db22-1292-p

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Sa1547: NORMALISATION OF COLONIC INFLAMMATION BY A NOVEL LONGACTING LIPIDATED INTERLEUKIN-22 IN AN ACUTE DSS COLITIS MODEL

Autor: Martijn van de Bunt, Ellen M. Straarup, Jens C. Norrild, Kristian Sass-Ørum, Anne Louise Kj⊘lbye, Rasmus Jorgensen

Publikováno v: Gastroenterology. 162:S-409

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d10427c8e0f410fbdb81b8e22189813
https://doi.org/10.1016/s0016-5085(22)60974-0

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Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

Autor: Kirsten Raun, Sara G. Vienberg, Birgitte Andersen, Tina Møller Tagmose, Xin Zhao, Xujia Zhang, Henning Thøgersen, Kristian Sass-Ørum, Ann Maria Kruse Hansen, Dan Han, Kirsten Lykkegaard, Goa Tingqing

Publikováno v: Biochemical Journal. 475:2985-2996

Fibroblast growth factors (FGF) 19, 21 and 23 are characterized by being endocrinely secreted and require co-receptor α-klotho or β-klotho (BKL) for binding and activation of the FGF receptors (FGFR). FGF15 is the rodent orthologue of human FGF19,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e7aa51ad1b5bc4f782e5fe16ff20b4
https://doi.org/10.1042/bcj20180555

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FGF21 decreases food intake and body weight in obese Göttingen minipigs

Autor: Xujia Zhang, Kirsten Raun, Birgitte Andersen, Berit Ø Christoffersen, Ellen Marie Straarup, Kristian Sass-Ørum, Kirsten Lykkegaard, Johannes Josef Fels

Publikováno v: Diabetes, obesitymetabolism. 21(3)

Aims The aim of this study was to assess the effect of FGF21 on food intake, body weight, body composition, glucose homeostasis, bone mineral density (BMD), cortisol and growth hormone (GH) in obese minipigs. The pig is a unique model for studying FG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ebc28cda8681472ac332753f49c7a2
https://pubmed.ncbi.nlm.nih.gov/30328263

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