ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Autor: Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Publikováno v: eLife, Vol 12 (2023)

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an

Externí odkaz: https://doaj.org/article/00504a5ab43345eda6eb322958fe33b8

Enhanced asymmetric blocked qPCR method for affordable detection of point mutations in KRAS oncogene

Autor: Ángel Maquieira, Luis Antonio Tortajada-Genaro, Ana Lázaro

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

[EN] An accurate genetic diagnostic is key for adequate patient management and the suitability of healthcare systems. The scientific challenge lies in developing methods to discriminate those patients with certain genetic variations present in tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63b00a4a338fa6923ad1f4254af3178
https://doi.org/10.1007/s00216-021-03229-3

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KRAS Assessment Following ESMO Recommendations for Colorectal Liver Metastases. Is It Always Worth It?

Autor: Olga Morató, Maria Villamonte, Patricia Sánchez-Velázquez, Eva Pueyo-Périz, Luís Grande, Benedetto Ielpo, Edoardo Rosso, Alessandro Anselmo, Fernando Burdío

Publikováno v: Healthcare; Volume 10; Issue 3; Pages: 472

Background: Genetic evaluation is essential in assessing colorectal cancer (CRC) and colorectal liver metastasis (CRLM). The aim of this study was to determine the pragmatic value of KRAS on oncological outcomes after CRLM according to the ESMO recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f8ea0c10b811ab1fdb9c294895556e

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