Zobrazeno 1 - 10
of 3 319
pro vyhledávání: '"KRAS MUTATION"'
Autor:
Rui Zhao, Yang Shu, Wei Xu, Fengxian Jiang, Pancen Ran, Liying Pan, Jingliang Wang, Weihao Wang, Jing Zhao, Yahui Wang, Guobin Fu
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Purpose The KRAS mutation is highly prevalent in NSCLC and is associated with poor efficacy of immunotherapy. Nevertheless, the impact of KRAS mutation, mutation subtypes, and co-mutations on the effectiveness of immunotherapy remains uncert
Externí odkaz:
https://doaj.org/article/856f91f3fa3240f6addacce2db4a42fd
Autor:
Sounetra Choudhury, Sandip Ghosh, Prosenjeet Chakraborty, Sayari Pal, Koustuv Ghosh, Subhankar Saha, Jitesh Midha, Vinu Sankar, Abhisek Mohata, Bitan Kumar Chattopadhyay, Shibajyoti Ghosh, Soumen Das, Biswarup Basu, Nilabja Sikdar
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Background and introduction Two and half percent of the Indian population suffer from gallbladder cancer (GBC). The primary factors that lead GBC are associated with mutation of several protooncogenes such as EGFR, ERBB2, Myc, and CCND1 alon
Externí odkaz:
https://doaj.org/article/2851fcba53e8421e8e44c2d035b5daa0
Autor:
Nathaniel Grabill, MD, Mena Louis, DO, Mariah Cawthon, MD, Claudia Gherasim, MD, James Chambers, MD
Publikováno v:
Radiology Case Reports, Vol 19, Iss 12, Pp 6016-6026 (2024)
Adenosquamous carcinoma of the pancreas (ASCP) is a rare and aggressive variant of pancreatic cancer, characterized by both adenocarcinoma and squamous cell carcinoma components. It presents significant diagnostic and therapeutic challenges due to it
Externí odkaz:
https://doaj.org/article/784af63923114cdf8e71bd5db5955890
Autor:
Jiaqi Ma, Xinsheng Nie, Xiangjiang Kong, Lingqing Xiao, Han Liu, Shengming Shi, Yupeng Wu, Na Li, Linlin Hu, Xiaofu Li
Publikováno v:
BMC Medical Imaging, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background The study aimed to identify the optimal model for predicting rectal cancer liver metastasis (RCLM). This involved constructing various prediction models to aid clinicians in early diagnosis and precise decision-making. Methods A r
Externí odkaz:
https://doaj.org/article/c31e990c5e5f43faa0b9be0b343d1d6f
Publikováno v:
International Journal of General Medicine, Vol Volume 17, Pp 4507-4517 (2024)
Yawan Jing,1,2 Ruixin Cheng,3 Hao Zeng,1 Qin Huang,1 Dongyu He,1 Jiayi Sun,1 Panwen Tian,1,4 Yalun Li1,4 1Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Heal
Externí odkaz:
https://doaj.org/article/61874a4feed143d3bb42c30cd01c1643
Publikováno v:
Precision Medical Sciences, Vol 13, Iss 3, Pp 148-166 (2024)
Abstract As one of the most prevalent tumors, colorectal cancer (CRC) owns complex pathogenesis and the high recurrence rate significantly influence the prognosis of patients with KRAS mutant CRC, to discovery the crosstalk among KEAP1‐NFE2L2 and o
Externí odkaz:
https://doaj.org/article/798c3ad3793246c4b8f8ff92642e320a
Publikováno v:
Big Data Mining and Analytics, Vol 7, Iss 3, Pp 590-602 (2024)
Kirsten rat sarcoma viral oncogene homolog (namely KRAS) is a key biomarker for prognostic analysis and targeted therapy of colorectal cancer. Recently, the advancement of machine learning, especially deep learning, has greatly promoted the developme
Externí odkaz:
https://doaj.org/article/e5318c9013be456dab7a3a654e626975
Autor:
Lova Sun, MD, MSCE, Yunyun Zhou, PhD, Elizabeth A. Handorf, PhD, Hossein Borghaei, DO, Jessica Bauman, MD, Charu Aggarwal, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 6, Iss 1, Pp 100755- (2025)
Introduction: The predictive and prognostic implications of different KRAS mutation (KRASm) subtypes in metastatic NSCLC have not been clearly defined. We used a nationwide observational database to investigate whether KRASm subtypes differ in their
Externí odkaz:
https://doaj.org/article/e4bc08556a0444da862a819628b99ca5
Autor:
Dingwen Zhang, Yuming Luo, Yan Lin, Zhou Fang, Hanhao Zheng, Mingjie An, Qingyu Xie, Zhuo Wu, Chao Yu, Jiabin Yang, Min Yu, Changhao Chen, Rufu Chen
Publikováno v:
Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)
Abstract Perineural invasion (PNI) represents a unique biological feature associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC), especially in the presence of KRAS mutations. Extracellular vesicle (EV)‐packaged circular RNAs (ci
Externí odkaz:
https://doaj.org/article/f922e7feea2940d5a5e1d2e7d19042f2
Autor:
Shangshang Ma, Kun Li, Rangrang Wang, Jiayi Qian, Yongfei Fan, Xichun Qin, Mingjun Li, Leilei Wu
Publikováno v:
Clinical Surgical Oncology, Vol 3, Iss 4, Pp 100069- (2024)
Background: Adjuvant chemotherapy (ACT) remains the current first-line systemic treatment option for patients with KRAS-mutated lung adenocarcinoma (LUAD), but the response is not effective. The prognosis of ACT in patients with KRAS mutations in sta
Externí odkaz:
https://doaj.org/article/69b8d1c2c4a44394a1599770d5e1680b