Zobrazeno 1 - 10
of 267
pro vyhledávání: '"KRAS G12D"'
Autor:
Margarita Dionysiou, Stavriani C. Makri, Shivani Ahlawat, Melike Guryildirim, Kristin W. Barañano, Mari L. Groves, Pedram Argani, Christine A. Pratilas
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
The RASopathies, collectively, are a spectrum of genetic syndromes caused by mutations in genes involved in the RAS/ mitogen-activated protein kinase (MAPK) pathway, including but not limited to PTPN11, NRAS, KRAS, HRAS, BRAF, and MAP2K1. Recognized
Externí odkaz:
https://doaj.org/article/1276b5df977e4efbbf6f69fcda642fbb
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The Kirsten rat sarcoma viral oncoprotein homolog (KRAS) is currently a primary focus of oncologists and translational scientists, driven by exciting results with KRAS-targeted therapies for non-small cell lung cancer (NSCLC) patients. While KRAS mut
Externí odkaz:
https://doaj.org/article/aca5e330a22840b09ee81bb5d601f5c2
Autor:
So-Youn Park, Venu Venkatarame Gowda Saralamma, Sagar Dattatraya Nale, Chang Joong Kim, Yun Seong Jo, Mohammad Hassan Baig, JungHwan Cho
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28495- (2024)
Oncogenic RAS mutations, commonly observed in human tumors, affect approximately 30% of cancer cases and pose a significant challenge for effective cancer treatment. Current strategies to inhibit the KRAS G12D mutation have shown limited success, emp
Externí odkaz:
https://doaj.org/article/3555ab74604d407baef18aa612469a64
Autor:
Qiang Cai, Quazi T. H. Shubhra
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/7e306b5777514e498b433c112dd4fc83
Autor:
Prasanna Srinivasan Ramalingam, Purushothaman Balakrishnan, Senthilnathan Rajendran, Arunachalam Jothi, Rajasekaran Ramalingam, Sivakumar Arumugam
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 3, Pp 2136-2156 (2023)
The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that
Externí odkaz:
https://doaj.org/article/8ccc40080dcd47c79e596476a0750727
Autor:
Amar Ajmal, Muhammad Danial, Maryam Zulfat, Muhammad Numan, Sidra Zakir, Chandni Hayat, Khulood Fahad Alabbosh, Magdi E. A. Zaki, Arif Ali, Dongqing Wei
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 551 (2024)
Single-point mutations in the Kirsten rat sarcoma (KRAS) viral proto-oncogene are the most common cause of human cancer. In humans, oncogenic KRAS mutations are responsible for about 30% of lung, pancreatic, and colon cancers. One of the predominant
Externí odkaz:
https://doaj.org/article/86e3c80421e3471e82e051885b8f873e
Akademický článek
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Autor:
Ivan Ranđelović, Kinga Nyíri, Gergely Koppány, Marcell Baranyi, József Tóvári, Attila Kigyós, József Tímár, Beáta G. Vértessy, Vince Grolmusz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2572 (2024)
Mutated genes may lead to cancer development in numerous tissues. While more than 600 cancer-causing genes are known today, some of the most widespread mutations are connected to the RAS gene; RAS mutations are found in approximately 25% of all human
Externí odkaz:
https://doaj.org/article/7529b61e5cd54d1f95b30df68f2d8c7d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Daisuke Minami, Nagio Takigawa, Yasuhiro Nakajima, Nobuaki Miyahara, Yasuyuki Mizumori, Mitsuhiro Ueda, Seiji Nakamura, Fumihiko Suzuki, Yoshiharu Sato, Kei Morikawa, Arihiko Kanehiro
Publikováno v:
Thoracic Cancer, Vol 13, Iss 11, Pp 1735-1738 (2022)
Abstract Here, we report a case of a pulmonary invasive mucinous adenocarcinoma harboring KRAS G12D, diagnosed from tumor samples containing a very small amount of tumor cells using next‐generation sequencing (NGS) and the recently developed Lung C
Externí odkaz:
https://doaj.org/article/776c21d1b0314ce1b5900e00d90e462c