Zobrazeno 1 - 10
of 24
pro vyhledávání: '"KRAS, Kirsten rat sarcoma viral oncogene homolog"'
Autor:
Song Han, Gerik W. Tushoski-Alemán, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Zhiguang Huo, Jonathan Licht, Thomas J. George, Carmen Allegra, Jose G. Trevino, Steven J. Hughes
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101070- (2025)
Oncogenic KRAS signaling plays a critical role in pancreatic ductal adenocarcinoma (PDAC) biology. Recent studies indicate that the combination of MEK and BCL-xL inhibition is synthetically lethal and holds promise for some types of solid cancers, ho
Externí odkaz:
https://doaj.org/article/191df517e9ab4a0b927c1c49c80b247d
Akademický článek
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Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 843-856 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
The epithelial lining of the intestine, particularly the stem cell compartment, is affected by harsh conditions in the luminal environment and also is susceptible to genotoxic agents such as radiation and chemotherapy. Therefore, the ability for inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c4548990c68ba5ebf409224d926be
http://www.sciencedirect.com/science/article/pii/S2352345X21002551
http://www.sciencedirect.com/science/article/pii/S2352345X21002551
Autor:
Haibo Cheng, Zhigui Wu, Jian Gao, Manru Li, Hongqi Chen, Dongdong Sun, Rui Zhang, Yuxian Shen, Qiang Xu, Xianjia Qi, Yang Sun, Mingxia Zhao, Dijun Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 149-166 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79268ea53d1ac127b470be7ad862d9e6
http://www.sciencedirect.com/science/article/pii/S2211383521002963
http://www.sciencedirect.com/science/article/pii/S2211383521002963
Autor:
Rebekka Van Hoof, Michal Szymonik, Stefanos K. Nomidis, Karen Hollanders, An Jacobs, Inge Nelissen, Patrick Wagner, Jef Hooyberghs
Publikováno v:
Sensors and Actuators B: Chemical
Nucleic acids duplex formation via hybridization is a crucial reaction in many processes and application across different disciplines. In life sciences the detection of mutations is an important application for which hybridization is used, e.g. in di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dad1bad7d75a270864d151971abdf89
https://lirias.kuleuven.be/handle/20.500.12942/702147
https://lirias.kuleuven.be/handle/20.500.12942/702147
Autor:
Marina Pasca di Magliano, Ben L. Allen, Filip Bednar, Hui-Ju Wen, Yaqing Zhang, Paloma E. Garcia, Howard C. Crawford, Michael K. Scales, Amara Z. Shaikh, Esther Kim, Yara S. El-Tawil, Maeva Adoumie, Deneen M. Wellik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)
Background & Aims Although the healthy pancreas consists mostly of epithelial cells, pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia, are characterized by an extensive accumulation of fibroinflammatory stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb9a4858459dea9c49e9fd7caeb3bb
http://europepmc.org/articles/PMC7399194
http://europepmc.org/articles/PMC7399194
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101089-(2021)
Translational Oncology
Translational Oncology
Highlights • Diabetes mellitus and hyperglycemia significantly affect the incidence and prognosis of colorectal cancer. • Evidence of the effects of metformin remain controversial in cancer prognosis. • Potential molecular mechanisms by which D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748b9c71d9b30a48c845ddaf0de4297
https://doi.org/10.1016/j.tranon.2021.101089
https://doi.org/10.1016/j.tranon.2021.101089
Publikováno v:
JHEP Reports
Summary Biliary tract cancers (BTCs) are aggressive epithelial malignancies that can arise at any point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising steadily over the past 40 years, highlighting the need to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba037ba710b2d3cec7628aee5054cce
https://doi.org/10.1016/j.jhepr.2021.100226
https://doi.org/10.1016/j.jhepr.2021.100226
Autor:
Kyung Soo Lee, Joungho Han, Yeonu Choi, Se-Hoon Lee, Teri J. Franks, Chohee Kim, Joon Young Choi, Hyunjin Park, Hwan-Ho Cho
Publikováno v:
European Journal of Radiology Open
European Journal of Radiology Open, Vol 8, Iss, Pp 100351-(2021)
European Journal of Radiology Open, Vol 8, Iss, Pp 100351-(2021)
Introduction To demonstrate semantic, radiomics, and the combined risk models related to the prognoses of pulmonary pleomorphic carcinomas (PCs). Methods We included 85 patients (M:F = 71:14; age, 35–88 [mean, 63 years]) whose imaging features were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fa61545f0abe8d23f910ae114d871d
https://doi.org/10.1016/j.ejro.2021.100351
https://doi.org/10.1016/j.ejro.2021.100351