Zobrazeno 1 - 10
of 380
pro vyhledávání: '"KPNA2"'
Autor:
Jie‐Xin Huang, Chun‐I Wang, Chia‐Yu Kuo, Ting‐Wei Chang, Yu‐Chin Liu, Ting‐Feng Hsiao, Chih‐Liang Wang, Chia‐Jung Yu
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 8, Pp 276-288 (2024)
Abstract Karyopherin α 2 (KPNA2, importin α1), a transport factor shuttling between the nuclear and cytoplasmic compartments, is involved in the nuclear import of proteins and participates in cellular processes such as cell cycle regulation, apopto
Externí odkaz:
https://doaj.org/article/8906b78fdc9d4b898ef7df83ed5e0374
Autor:
Xia Chen, Hui Wei, Ailin Yue, Huiyun Zhang, Ya Zheng, Weiming Sun, Yongning Zhou, Yuping Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract RNA-binding proteins (RBPs) play critical roles in genome regulation. In this study, we explored the latent function of KPNA2, which is an essential member of the RBP family, in the regulation of alternative splicing (AS) in gastric cancer (
Externí odkaz:
https://doaj.org/article/2c8da778eea749b4855f752e2cbac0d9
Akademický článek
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Autor:
Yuan Xia, Dan Wang, Huijie Zhao, Tingyi Meng, Qingling Jiang, Zhaohai Pan, Guoli Wang, Tianyue An, Bohan Li, Sixue Bi, Huikai Wang, Jun Lu, Hongfu Liu, Haiyan Lin, Chunhua Lin, Qiusheng Zheng, Defang Li
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107327- (2024)
Evidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, the regulatory mechanism of TMOD1 in tumor progression is still unclear. Here, we showed that TMOD1 was highly expressed i
Externí odkaz:
https://doaj.org/article/03950e4f790f411a80587bc4b9bf27d5
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Hsa_circ_0022383 (circ_0022383) is a newly discovered circRNA. Its functions and relevant molecular mechanisms in tumorigenesis have not been reported. Here we aimed to explore how circ_0022383 regulates the tumorigenesis of non-small-cell l
Externí odkaz:
https://doaj.org/article/aeb16c2156b74df0aed614c86361c7fd
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-25 (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Muhammad Suleman, Afsheen Said, Haji Khan, Shoaib Ur Rehman, Abdulrahman Alshammari, Sergio Crovella, Hadi M. Yassine
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surfaced on 31 December, 2019, and was identified as the causative agent of the global COVID-19 pandemic, leading to a pneumonia-like disease. One of its accessory proteins, ORF6, has been
Externí odkaz:
https://doaj.org/article/30a6c7b22f014456a1ed251918d40bf2
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Purpose Angiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear transport protein family, was recently shown to be induced by hyp
Externí odkaz:
https://doaj.org/article/79fff517edf645bd80c7f847b753629d
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Melanoma is a common type of skin cancer, and its incidence is increasing gradually. Exploring melanoma pathogenesis helps to find new treatments. Objective We aimed to explore the potential molecular mechanisms by which CREB1 reg
Externí odkaz:
https://doaj.org/article/aa1ec217425840c2b2f25b598ffcc69b