Zobrazeno 1 - 10
of 85
pro vyhledávání: '"KOUSHIRO OHTSUBO"'
Autor:
Hiroshi Kotani, Tomoyoshi Yamano, Justin C. Boucher, Shigeki Sato, Hiroyuki Sakaguchi, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Takumi Nishiuchi, Hiroko Oshima, Masanobu Oshima, Marco L. Davila, Seiji Yano
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-6 (2024)
Abstract Precision medicine has drastically changed cancer treatment strategies including KRAS-mutant cancers which have been undruggable for decades. While intrinsic or acquired treatment resistance remains unresolved in many cases, epigenome-target
Externí odkaz:
https://doaj.org/article/b9b2e0380ce9438081e69ef411f40371
Autor:
Tadayoshi Hashimoto, Yoshiaki Nakamura, Yoshito Komatsu, Satoshi Yuki, Naoki Takahashi, Naohiro Okano, Hidekazu Hirano, Koushiro Ohtsubo, Takashi Ohta, Eiji Oki, Tomohiro Nishina, Hisateru Yasui, Hisato Kawakami, Taito Esaki, Nozomu Machida, Ayako Doi, Shogen Boku, Toshihiro Kudo, Yoshiyuki Yamamoto, Akiyoshi Kanazawa, Tadamichi Denda, Masahiro Goto, Naoko Iida, Hiroshi Ozaki, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Hideaki Bando, Yoichi Naito, Takayuki Yoshino
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background While advanced gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs), acquired resistance from specific mutations in KIT or PDGFRA frequently occurs. We aimed to assess the utility of
Externí odkaz:
https://doaj.org/article/8d89e02235024fa88d2552871e8438cb
Autor:
Hiroshi Kotani, Hiroko Oshima, Justin C. Boucher, Tomoyoshi Yamano, Hiroyuki Sakaguchi, Shigeki Sato, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Takumi Nishiuchi, Masanobu Oshima, Marco L. Davila, Seiji Yano
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-13 (2024)
Abstract Background KRAS mutations frequently occur in cancers, particularly pancreatic ductal adenocarcinoma, colorectal cancer, and non-small cell lung cancer. Although KRAS G12C inhibitors have recently been approved, effective precision therapies
Externí odkaz:
https://doaj.org/article/e76a3f8454924a68ab32ec86f27f0f26
Autor:
Akihiro Nishiyama, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Kaname Yamashita, Koushiro Ohtsubo, Shigeki Nanjo, Seiji Yano, Keishi Mizuguchi, Hiroko Ikeda, Shinji Takeuchi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
We report a case of limited effectiveness of dabrafenib and trametinib in a 59-year-old man with poorly differentiated lung carcinoma and a rare BRAF K601E mutation. The patient, unresponsive to chemotherapy and immunotherapy, received these targeted
Externí odkaz:
https://doaj.org/article/67c78e62172b42b580e93f5cade774a9
Autor:
Akihiro Nishiyama, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Kaname Yamashita, Koushiro Ohtsubo, Keishi Mizuguchi, Hiroko Ikeda, Kenji Iino, Hirofumi Takemura, Shinji Takeuchi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
In the realm of rare cardiac tumors, intimal sarcoma presents a formidable challenge, often requiring innovative treatment approaches. This case report presents a unique instance of primary intimal sarcoma in the left atrium, underscoring the critica
Externí odkaz:
https://doaj.org/article/5b28db188c8a4b39872e162ed79f8cf7
Autor:
Rikako Ueda, Naho Yamamoto, Yuki Hori, Kouji Yoshida, Koushiro Ohtsubo, Takeshi Terashima, Tsutomu Shimada, Yoshimichi Sai
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Background Gemcitabine plus nab-paclitaxel (GnP) therapy is used for unresectable pancreatic ductal adenocarcinoma, but may cause interstitial lung disease (ILD) as a serious side effect. However, the risk factors for ILD in patients receivi
Externí odkaz:
https://doaj.org/article/34f0e58db96647bc849ca27f4f0a129a
Autor:
Mitsuyoshi Okazaki, Hidehiro Tajima, Yoshinao Ohbatake, Hiroyuki Shinbashi, Shinichi Nakanuma, Isamu Makino, Itasu Ninomiya, Sachio Fushida, Koushiro Ohtsubo, Tetsuo Ohta
Publikováno v:
BMC Surgery, Vol 20, Iss 1, Pp 1-6 (2020)
Abstract Background Rhabdomyosarcoma (RMS), a malignant neoplasm that normally differentiates to form striated muscle, is the most common type of childhood soft tissue sarcoma. However, it infrequently occurs in adults and is uncommon in the liver. W
Externí odkaz:
https://doaj.org/article/84fd516b2876455a95bd5668c93acf21
Autor:
Yuta Adachi, Naohiro Yanagimura, Chiaki Suzuki, Sakiko Ootani, Azusa Tanimoto, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi, Seiji Yano
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-4 (2020)
Abstract Background A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the drugs in combinati
Externí odkaz:
https://doaj.org/article/248ccedf4c7e4010a00b7c2f3c8a2c40
Autor:
Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda, Seiji Yano
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-4 (2018)
Abstract Background Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresectable PCS. Case present
Externí odkaz:
https://doaj.org/article/7a69227862094f0caf65786b14b15e03
Autor:
Takashi Okai, Koushiro Ohtsubo, Junta Sakai, Hiroyuki Watanabe, Yoshiharu Motoo, Atsuhiro Kawashima, Sawabu Norio
Publikováno v:
Canadian Journal of Gastroenterology, Vol 14, Iss 9, Pp 761-766 (2000)
PURPOSE: To clarify whether the depth of ulceration evaluated by endoscopic ultrasonography (EUS) influences a modified dual therapy with amoxicillin and lansoprazole for the treatment of Helicobacter pylori-positive patients with gastric ulcer.
Externí odkaz:
https://doaj.org/article/a5a37c7190c3491c8c77343d64d1ae18