Zobrazeno 1 - 10
of 91
pro vyhledávání: '"KOTARO KUMAGAI"'
Autor:
Ai Toyodome, Seiichi Mawatari, Hiromi Eguchi, Midori Takeda, Kotaro Kumagai, Ohki Taniyama, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Masanori Ikeda, Akio Ido
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) affect the efficacy of direct-acting antivirals (DAAs). In this study, we aimed to clarify the susceptibility of the coexistence of nonstructural (NS) 5A Q24K/L28M/R30Q (o
Externí odkaz:
https://doaj.org/article/3fe6eb0227284a16be2ea8103fd1f582
Autor:
Kotaro Kumagai, Shuji Kanmura, Seiichi Mawatari, Yuko Nakamura, Hiromi Eguchi, Oki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Keita Shimata, Taizo Hibi, Akio Ido
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: Glycoprotein non-metastatic melanoma protein B (GPNMB) is expressed in macrophages during recovery from acute liver injury (ALI) in carbon tetrachloride (CCl4)-induced liver injury model mice. In this retrospective study, we assessed whet
Externí odkaz:
https://doaj.org/article/a1f40279821e4041848a49127e33c2db
Autor:
Keisuke Kakisaka, Nobuaki Nakayama, Kotaro Kumagai, Takuro Hisanaga, Takayuki Kondo, Toru Setsu, Shunsuke Sato, Yohei Kooka, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Ryuzo Abe, Taka-aki Nakada, Yoshihiro Ikura, Kenichi Harada, Takuya Genda, Shuji Terai, Naoya Kato, Taro Takami, Akio Ido, Satoshi Mochida, Takayuki Matsumoto, Atsushi Tanaka
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 4, Pp 497-504 (2023)
Background and Aims: Acute liver injury (ALI) due to autoimmune hepatitis (AIH) can be treated by immunosuppression. In contrast, idiosyncratic drug-induced liver injury (DILI) had a poor prognosis. DILI thus needs to be distinguished from non-DILI.
Externí odkaz:
https://doaj.org/article/41e7930ab9084fc1bab5aaa463fc1040
Autor:
Seiichi Mawatari, Kotaro Kumagai, Kohei Oda, Kazuaki Tabu, Sho Ijuin, Kunio Fujisaki, Shuzo Tashima, Yukiko Inada, Hirofumi Uto, Akiko Saisyoji, Yasunari Hiramine, Masafumi Hashiguchi, Tsutomu Tamai, Takeshi Hori, Ohki Taniyama, Ai Toyodome, Haruka Sakae, Takeshi Kure, Kazuhiro Sakurai, Akihiro Moriuchi, Shuji Kanmura, Akio Ido
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Background The features of hepatitis C virus patients with a sustained virologic response (SVR) who developed hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) therapy are unclear. Methods The study population included 1494 DAA-SVR p
Externí odkaz:
https://doaj.org/article/a9d631c3572b48d2b03ea489655c1018
Autor:
Nao Nishikoba, Kotaro Kumagai, Shuji Kanmura, Yuko Nakamura, Mayumi Ono, Hiromi Eguchi, Tomomi Kamibayashiyama, Kohei Oda, Seiichi Mawatari, Shiroh Tanoue, Shinichi Hashimoto, Hirohito Tsubouchi, Akio Ido
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Backgrounds and Aims: Hepatocyte Growth Factor (HGF)-MET signaling is known to promote biological functions such as cell survival, cell motility, and cell proliferation. However, it is unknown if HGF-MET alters the macrophage phenotype. In this study
Externí odkaz:
https://doaj.org/article/45c402f89fa444ca809e820f37cca1ab
Autor:
Kazuaki Tabu, Seiichi Mawatari, Kohei Oda, Kotaro Kumagai, Yukiko Inada, Hirofumi Uto, Akiko Saisyoji, Yasunari Hiramine, Masafumi Hashiguchi, Tsutomu Tamai, Takeshi Hori, Kunio Fujisaki, Dai Imanaka, Takeshi Kure, Ohki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuhiro Sakurai, Akihiro Moriuchi, Shuji Kanmura, Akio Ido
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237475 (2020)
Background and aimsDirect-acting antivirals (DAAs) against hepatitis C virus (HCV) exert high anti-HCV activity and are expected to show anti-inflammatory effects associated with HCV elimination. Furthermore, hepatocellular carcinoma (HCC) is known t
Externí odkaz:
https://doaj.org/article/77e19cc7fd2f44569864b15ba39951ef
Autor:
Nobuhiro Hiraishi, Shuji Kanmura, Kouhei Oda, Shiho Arima, Kotaro Kumagai, Seiichi Mawatari, Shiroh Tanoue, Fumisato Sasaki, Shinichi Hashimoto, Akio Ido
Publikováno v:
Biochemistry and Biophysics Reports, Vol 20, Iss , Pp - (2019)
Colorectal cancer is a multi-factorial disease involving genetic, environmental and lifestyle risk factors. In recent years, many changes in the bacterial composition of the intestinal microflora have been reported in colorectal cancer, suggesting th
Externí odkaz:
https://doaj.org/article/fc6ca359adb6438696cab75cb38cfc7b
Autor:
Seiichi Mawatari, Kohei Oda, Kazuaki Tabu, Sho Ijuin, Kotaro Kumagai, Kunio Fujisaki, Masafumi Hashiguchi, Yukiko Inada, Hirofumi Uto, Yasunari Hiramine, Takeshi Kure, Takeshi Hori, Oki Taniyama, Ai Kasai, Tsutomu Tamai, Akihiro Moriuchi, Akio Ido
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198642 (2018)
OBJECTIVE:The present study aimed to reveal the factors associated with virologic failure in sofosbuvir and ledipasvir (SOF/LDV)-treated patients, and identify baseline NS5A or NS5B resistance-associated substitutions (RASs). METHODS:Four hundred nin
Externí odkaz:
https://doaj.org/article/dd5b56e94e8f4b56a63aad408af02b30
Autor:
Rie Ibusuki, Hirofumi Uto, Kohei Oda, Akihiko Ohshige, Kazuaki Tabu, Seiichi Mawatari, Kotaro Kumagai, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174913 (2017)
Neutrophil infiltration of the liver is a typical feature of alcoholic liver injury. Human neutrophil peptide (HNP)-1 is an antimicrobial peptide secreted by neutrophils. The aim of this study was to determine if HNP-1 affects ethanol-induced liver i
Externí odkaz:
https://doaj.org/article/3fcd7cd994b040e89977b5e26e5b349f
Autor:
Kotaro Kumagai, Kazuaki Tabu, Fumisato Sasaki, Yoichiro Takami, Yuko Morinaga, Seiichi Mawatari, Shinichi Hashimoto, Shiroh Tanoue, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143413 (2015)
Glycoprotein nonmetastatic melanoma B (Gpnmb), a transmembrane glycoprotein that is expressed in macrophages, negatively regulates inflammation. We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino
Externí odkaz:
https://doaj.org/article/2ebe0f32e9c8445a989f507947fcbb0c