Zobrazeno 1 - 10
of 21
pro vyhledávání: '"KOSUKE TANEGASHIMA"'
Autor:
Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Rina Iwase, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Takahiko Hara
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 247-256 (2017)
CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various t
Externí odkaz:
https://doaj.org/article/f048954521c2406293e2893fe84fb88f
Autor:
Kosuke Tanegashima, Shiki Okamoto, Yuki Nakayama, Choji Taya, Hiroshi Shitara, Rie Ishii, Hiromichi Yonekawa, Yasuhiko Minokoshi, Takahiko Hara
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10321 (2010)
BACKGROUND: CXCL14 is a chemoattractant for macrophages and immature dendritic cells. We recently reported that CXCL14-deficient (CXCL14(-/-)) female mice in the mixed background are protected from obesity-induced hyperglycemia and insulin resistance
Externí odkaz:
https://doaj.org/article/05a836ce881e4b3db5ecb24c99208f4a
Autor:
Kojiro Tsujihana, Kosuke Tanegashima, Yasuko Santo, Hiroyuki Yamada, Sota Akazawa, Ryuta Nakao, Keiko Tominaga, Risa Saito, Yasumasa Nishito, Ryu-Ichiro Hata, Tomonori Nakamura, Iori Murai, Yuka Kono, Maho Sugawa, Miki Tanioka, Gyohei Egawa, Masao Doi, Tadashi Isa, Kenji Kabashima, Takahiko Hara, Hitoshi Okamura
Publikováno v:
Proceedings of the National Academy of Sciences (PNAS). 119(25)
The epidermis is the outermost layer of the skin and the body’s primary barrier to external pathogens; however, the early epidermal immune response remains to be mechanistically understood. We show that the chemokine CXCL14, produced by epidermal k
Autor:
Rena Takahashi, Naoto Naruse, Rina Iwase, Kohei Tsuji, Akira Shigenaga, Hideko Nuriya, Takahiko Hara, Akira Otaka, Kosuke Tanegashima
Publikováno v:
EBioMedicine
EBioMedicine, Vol 24, Iss C, Pp 247-256 (2017)
EBioMedicine, Vol 24, Iss C, Pp 247-256 (2017)
CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various t
Autor:
Masabumi Funakoshi, Takahiko Hara, Yasumasa Nishito, Yukiko Sato-Miyata, Toshiro Aigaki, Kosuke Tanegashima
Publikováno v:
Genes to Cells. 22:71-83
We carried out liquid chromatography-tandem mass spectrometry analysis of metabolites in mice. Those metabolome data showed that hepatic glucose content is reduced, but that brain glucose content is unaffected, during fasting, consistent with the pri
Publikováno v:
The International journal of developmental biology. 63(1-2)
Latrophilin2 (Lphn2) is an adhesion-class of G protein-coupled receptor with an unknown function in development. Here, we show that Xenopus laevis lphn2 (Xlphn2) is involved in the migration and differentiation of neural crest (NC) cells and placode
Autor:
Kohei Sato, Kohei Tsuji, Akira Otaka, Kosuke Tanegashima, Tsubasa Inokuma, Akira Shigenaga, Ken Sakamoto, Takahiko Hara
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5909-5914
CXCL14 is a CXC-type chemokine that exhibits chemotactic activity for immature dendritic cells, activated macrophages, and activated natural killer cells. However, its specific receptor and signaling pathway remain obscure. Recently, it was reported
Autor:
Yusaku Kodaka, Takahiko Hara, Kosuke Tanegashima, Kenji Kitajima, Kiyoko Tanaka, Ryoichi Matsuda
Publikováno v:
Experimental Cell Research. 331:309-319
LIM homeobox transcription factor Lhx2 is known to be an important regulator of neuronal development, homeostasis of hair follicle stem cells, and self-renewal of hematopoietic stem cells; however, its function in skeletal muscle development is poorl
Autor:
Takahiko Hara, Kosuke Tanegashima
Publikováno v:
Journal of Biochemistry. 151:469-476
CXCL14 is a member of the CXC chemokine family. CXCL14 possesses chemoattractive activity for activated macrophages, immature dendritic cells and natural killer cells. CXCL14-deficient mice do not exhibit clear immune system abnormalities, suggesting
Publikováno v:
Experimental Cell Research. 316:1263-1270
CXCL14 is a CXC-type chemokine acting on tissue macrophages, immature dendritic cells, natural killer cells, and epithelial tumor cells. It also serves as a metabolic regulator in obese mice by blunting insulin activity. In contrast to other CXC chem