Zobrazeno 1 - 10
of 542
pro vyhledávání: '"KOSAKU, HIROTA"'
Autor:
Kosaku Hirota, Hideo Inoue, Yoshinari Sawama, Yoshifumi Maki, Yasunari Monguchi, Yukio Kitade, Kanoko Ikawa, Yusuke Iida, Hironao Sajiki
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6519-6546 (2012)
The reaction of 5-halogenouracil and uridine derivatives 1 and 7 with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the nature of the carbanions. Three different types of rea
Externí odkaz:
https://doaj.org/article/14c2c06b12004165997f486bc07042a3
Autor:
Yoshifumi Maki, Yasunari Monguchi, Yoshinari Sawama, Yukio Kitade, Kanoko Ikawa, Hideo Inoue, Yusuke Iida, Kosaku Hirota, Hironao Sajiki
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6519-6546 (2012)
Molecules
Volume 17
Issue 6
Pages 6519-6546
Molecules
Volume 17
Issue 6
Pages 6519-6546
The reaction of 5-halogenouracil and uridine derivatives 1 and 7 with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the nature of the carbanions. Three different types of rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4abe9d9f5068536afe6ee313ca9a54
http://www.mdpi.com/1420-3049/17/6/6519
http://www.mdpi.com/1420-3049/17/6/6519
Autor:
Kosaku Hirota, Kana Nunome, Takahiro Taira, Masatoshi Inden, Hiroyoshi Ariga, Shinsuke Nakagawa, Takashi Yanagida, Yoshihisa Kitamura, Masami Niwa, Sanae M.M. Iguchi-Ariga, Shizuma Ishikawa, Shin Miyazaki
Publikováno v:
Journal of Neurochemistry. 105:2418-2434
Parkinson's disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors of dopamine degradation have been used for PD therapy, cell death progresses during treatment. DJ-1, a causative gene product of a familial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::550b74c9a913bc898c07b7e84d5b3249
https://doi.org/10.1111/j.1471-4159.2008.05327.x
https://doi.org/10.1111/j.1471-4159.2008.05327.x
Autor:
Kosaku, HIROTA
Publikováno v:
岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy. 55:31-42
ウラシル誘導体は核酸の構成塩基として重要であり、その反応性に関する研究が広範囲に実施されている。筆者の研究室ではウラシル誘導体が求核試薬に対して特色ある反応性を示すこ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::8b51c6c03023eda2a109a96c3c2093cd
http://id.nii.ac.jp/1076/00012804/
http://id.nii.ac.jp/1076/00012804/
Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH4OAc
Autor:
Kosaku Hirota, Tomohiro Maegawa, Tomoteru Mizusaki, Hironao Sajiki, Akinori Mori, Takashi Ikawa
Publikováno v:
Organic Letters. 8:987-990
A Pd/C-catalyzed deoxygenation method of phenolic hydroxyl groups via aryl triflates or mesylates using Mg metal in MeOH at room temperature was developed. The addition of NH4OAc dramatically affects the reactivity and reaction rate. This method is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76e5a459adb64b5ce3451014c5efe99
https://doi.org/10.1021/ol060045q
https://doi.org/10.1021/ol060045q
Autor:
Tomohiro Maegawa, Nobuhiro Ito, Hironao Sajiki, Hiroyoshi Esaki, Kosaku Hirota, Tsuneaki Maesawa
Publikováno v:
Tetrahedron Letters. 46:6995-6998
An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H–D exchange results on the aromatic ring syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22a2362b787c57b1c5f67139c5804c56
https://doi.org/10.1016/j.tetlet.2005.08.067
https://doi.org/10.1016/j.tetlet.2005.08.067
Publikováno v:
Tetrahedron. 61:8499-8504
1-(2,3-Anhydro-5-deoxy-4,5-didehydro-α-l-erythro-pent-4-enofuranosyl)uracil 4 was obtained by the treatment of 5′-iodo-2′,3′-epoxyuridine 5 with LiHMDS in excellent yield. The pyrimidine nucleoside 4 possesses quite unique vinyl epoxide moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d63a2c523479c4a28c300d202e8ca3f
https://doi.org/10.1016/j.tet.2005.06.053
https://doi.org/10.1016/j.tet.2005.06.053
Publikováno v:
Synlett. :1385-1388
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D 2 O-H 2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02c0ca8cc4bc7ac63f5e1aa5816ee9f6
https://doi.org/10.1055/s-2005-868489
https://doi.org/10.1055/s-2005-868489
Publikováno v:
Tetrahedron. 60:6901-6911
Recently we have reported undesirable and frequent deprotection of the TBDMS protective group of a variety of hydroxyl functions occurred under neutral and mild hydrogenation conditions using 10% Pd/C in MeOH. The deprotection of silyl ethers is susc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45b910dda415ad5de6102e99fc038e2
https://doi.org/10.1016/j.tet.2004.05.098
https://doi.org/10.1016/j.tet.2004.05.098
Publikováno v:
Tetrahedron. 60:6189-6195
Commercial Pd/C catalysts show different catalytic activity toward the deprotection of silyl and THP ethers. The Pd/C purchased from Merck and ACROS exhibits marked tendency to cleave these protective groups unexpectedly without hydrogen conditions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5107c062bcabed1213379bfa9fc63409
https://doi.org/10.1016/j.tet.2004.05.040
https://doi.org/10.1016/j.tet.2004.05.040