Výsledky vyhledávání - "KOOPERBERG, CHARLES L."

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Autor: Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M, Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K, Aslibekyan, Stella, Ballantyne, Christie M, Bielak, Lawrence F, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Broome, Jai G, Conomos, Matthew P, Correa, Adolfo, Cupples, L Adrienne, Curran, Joanne E, Freedman, Barry I, Guo, Xiuqing, Hindy, George, Irvin, Marguerite R, Kardia, Sharon LR, Kathiresan, Sekar, Khan, Alyna T, Kooperberg, Charles L, Laurie, Cathy C, Liu, X Shirley, Mahaney, Michael C, Manichaikul, Ani W, Martin, Lisa W, Mathias, Rasika A, McGarvey, Stephen T, Mitchell, Braxton D, Montasser, May E, Moore, Jill E, Morrison, Alanna C, O'Connell, Jeffrey R, Palmer, Nicholette D, Pampana, Akhil, Peralta, Juan M, Peyser, Patricia A, Psaty, Bruce M, Redline, Susan, Rice, Kenneth M, Rich, Stephen S, Smith, Jennifer A, Tiwari, Hemant K, Tsai, Michael Y, Vasan, Ramachandran S, Wang, Fei Fei, Weeks, Daniel E, Weng, Zhiping, Wilson, James G, Yanek, Lisa R, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group, Neale, Benjamin M, Sunyaev, Shamil R, Abecasis, Gonçalo R, Rotter, Jerome I, Willer, Cristen J, Peloso, Gina M, Natarajan, Pradeep, Lin, Xihong

Publikováno v: Nature genetics, vol 52, iss 9

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose STAAR (variant-set test f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e52aef530ecaa2ce04de16503b6abfa5
https://escholarship.org/uc/item/61s9b995

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