Zobrazeno 1 - 10
of 366
pro vyhledávání: '"KOJI YOSHIMOTO"'
Autor:
Mari Kirishima, Seiya Yokoyama, Toshiaki Akahane, Nayuta Higa, Hiroyuki Uchida, Hajime Yonezawa, Kei Matsuo, Junkoh Yamamoto, Koji Yoshimoto, Ryosuke Hanaya, Akihide Tanimoto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic biomarkers of GBMs, the histomorphological features that predict their prognosis rem
Externí odkaz:
https://doaj.org/article/ca1a6b39034b432fb711dd4038deb0be
Autor:
Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Takuro Isoda, Ataru Nishimura, Koichi Arimura, Akira Nakamizo, Koji Yoshimoto, Kousei Ishigami
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Moyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brai
Externí odkaz:
https://doaj.org/article/36b3962ea0ed41feac603bf6db23ea36
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109735- (2024)
Summary: Lysosomes, the hub of metabolic signaling, are associated with various diseases and participate in autophagy by supplying nutrients to cells under nutrient starvation. However, their function and regulation under glucose starvation remain un
Externí odkaz:
https://doaj.org/article/c0083f3530d141338dd44d317e895de3
Autor:
Hirokazu Takami, Kaishi Satomi, Kohei Fukuoka, Taishi Nakamura, Shota Tanaka, Akitake Mukasa, Nobuhito Saito, Tomonari Suzuki, Takaaki Yanagisawa, Kazuhiko Sugiyama, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga, Kaoru Tamura, Taketoshi Maehara, Masahiro Nonaka, Akio Asai, Kiyotaka Yokogami, Hideo Takeshima, Toshihiko Iuchi, Keiichi Kobayashi, Koji Yoshimoto, Keiichi Sakai, Yoichi Nakazato, Masao Matsutani, Motoo Nagane, Ryo Nishikawa, Koichi Ichimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract We have previously reported that 12p gain may predict the presence of malignant components and poor prognosis for CNS germ cell tumor (GCT). Recently, 3p25.3 gain was identified as an independent predictor of poor prognosis for testicular GC
Externí odkaz:
https://doaj.org/article/b1edffdef3be461c8605db7e0072f4c6
Autor:
Noritoshi Shirozu, Masahiro Ohgidani, Nobuhiro Hata, Shunya Tanaka, Shogo Inamine, Noriaki Sagata, Tetsuaki Kimura, Ituro Inoue, Koichi Arimura, Akira Nakamizo, Ataru Nishimura, Naoki Maehara, Soh Takagishi, Katsuma Iwaki, Tomohiro Nakao, Keiji Masuda, Yasunari Sakai, Masahiro Mizoguchi, Koji Yoshimoto, Takahiro A. Kato
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2 polarized microglia in ischemic stroke, suggesting that microglia may be involved in the pathophysiology of MMD; however, existing approaches are not applicabl
Externí odkaz:
https://doaj.org/article/cf03e8acbc4144bdad49470e7083ea0b
Autor:
Ryosuke OTSUJI, Nobuhiro HATA, Yusuke FUNAKOSHI, Daisuke KUGA, Osamu TOGAO, Ryusuke HATAE, Yuhei SANGATSUDA, Yutaka FUJIOKA, Kosuke TAKIGAWA, Aki SAKO, Kazufumi KIKUCHI, Tadamasa YOSHITAKE, Hidetaka YAMAMOTO, Masahiro MIZOGUCHI, Koji YOSHIMOTO
Publikováno v:
Neurologia Medico-Chirurgica, Vol 63, Iss 8, Pp 364-374 (2023)
We aimed to retrospectively determine the resection rate of fluid-attenuated inversion recovery (FLAIR) lesions to evaluate the clinical effects of supramaximal resection (SMR) on the survival of patients with glioblastoma (GBM). Thirty-three adults
Externí odkaz:
https://doaj.org/article/d7296ab8103e41a7be11e4dbd0940fb9
Autor:
Kenji Miki, Mikako Yagi, Naoki Noguchi, Yura Do, Ryosuke Otsuji, Daisuke Kuga, Dongchon Kang, Koji Yoshimoto, Takeshi Uchiumi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Glioblastoma, a malignant tumor, has no curative treatment. Recently, mitochondria have been considered a potential target for treating glioblastoma. Previously, we reported that agents initiating mitochondrial dysfunction were effective und
Externí odkaz:
https://doaj.org/article/d6c411e507084146b2b25e1ac2ed7142
Autor:
Nayuta Higa, Toshiaki Akahane, Taiji Hamada, Hajime Yonezawa, Hiroyuki Uchida, Ryutaro Makino, Shoji Watanabe, Tomoko Takajo, Seiya Yokoyama, Mari Kirishima, Kei Matsuo, Shingo Fujio, Ryosuke Hanaya, Akihide Tanimoto, Koji Yoshimoto
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 49-60 (2023)
Abstract Background We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)‐wildtype glioblastomas (GBMs). Methods We sequenced
Externí odkaz:
https://doaj.org/article/4c6bd20f275d4736930ec1130baa61f2
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial oxidative phosphorylation (OXPHOS) is not well utilized. Here, we inv
Externí odkaz:
https://doaj.org/article/7ba0da91d2b844a6b7d7f1fb8014ae2c
Autor:
Nayuta HIGA, Toshiaki AKAHANE, Seiya YOKOYAMA, Hajime YONEZAWA, Hiroyuki UCHIDA, Shingo FUJIO, Mari KIRISHIMA, Kosuke TAKIGAWA, Nobuhiro HATA, Keita TOH, Junkoh YAMAMOTO, Ryosuke HANAYA, Akihide TANIMOTO, Koji YOSHIMOTO
Publikováno v:
Neurologia Medico-Chirurgica, Vol 62, Iss 9, Pp 391-399 (2022)
Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations in central nervous system (CNS) tumors. Accordingly, the fifth edition of the World Health Organization (WHO) CNS tumor c
Externí odkaz:
https://doaj.org/article/71f1b1a333e64450a6db85d29bf4ba3a