Zobrazeno 1 - 10
of 164
pro vyhledávání: '"KOJI OHNISHI"'
Autor:
Yoichi Saito, Yukio Fujiwara, Yuji Miyamoto, Koji Ohnishi, Yuta Nakashima, Yasuhiko Tabata, Hideo Baba, Yoshihiro Komohara
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10199-10211 (2023)
Abstract Aims Mismatch‐repair deficiency and microsatellite instability‐high (dMMR/MSI‐H) colorectal cancer (CRC) is treated with programmed death (PD)‐1 antibody regardless of PD‐ligand (L)1 expression in tumor cells. We previously found t
Externí odkaz:
https://doaj.org/article/85c9c1f64bac4835bef398c08bc6d691
Autor:
Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a r
Externí odkaz:
https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d
Autor:
Kazuya Matsumoto, Yoshinori Kushiyama, Akio Izumi, Koji Ohnishi, Masahiko Miura, Yasufumi Ohuchi, Ikuko Hori, Tomonori Nakamura, Kotaro Hori, Kenji Koshino, Junko Kobayashi, Nagisa Yoshino, Ushio Hoshino, Takekiyo Okumura, Takashi Tanimura, Shinsuke Tanaka, Shino Tanaka, Tadashi Nabika, Tatsuaki Nozu, Yutaka Wakatsuki, Syunsuke Katayama, Shizue Yoshioka, Kenichi Ito, Akiko Uchida, Noriji Yuhara, Hisashi Noma, Hajime Isomoto
Publikováno v:
Diagnostics, Vol 12, Iss 9, p 2257 (2022)
The 5-year survival rate for pancreatic cancer has improved (10%) but remains worse than that for other cancers. Early pancreatic cancer diagnosis is challenging, and delayed diagnosis can delay treatment, which impairs survival. Practitioners do not
Externí odkaz:
https://doaj.org/article/edbce94ba36f4b73b4865a92ee85b5d5
Autor:
Keiichiro Kumamoto, Takashi Tasaki, Koji Ohnishi, Michihiko Shibata, Shohei Shimajiri, Masaru Harada, Yoshihiro Komohara, Toshiyuki Nakayama
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The induction of an anti-cancer immune responses is potentially associated with the efficacy of anti-cancer therapy. Recent studies have indicated that sinus macrophages in regional lymph nodes are involved in anti-cancer immune responses in the canc
Externí odkaz:
https://doaj.org/article/8090f8ac3705467ba7ecda54566c853e
Autor:
Yukio Fujiwara, Koji Ohnishi, Hasita Horlad, Yoichi Saito, Daisuke Shiraishi, Hiroto Takeya, Daiki Yoshii, Shinjiro Kaieda, Tomoaki Hoshino, Yoshihiro Komohara
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 9, Pp n/a-n/a (2020)
Abstract Objectives Septic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it is known that increased serum levels of CD163 are observed in septic/endotoxin shock patients, the exact func
Externí odkaz:
https://doaj.org/article/a50d7bbd6d5245e0a3beb21df1fba037
Autor:
Takuya Shiota, Yuko Miyasato, Koji Ohnishi, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase, Motohiro Takeya, Yoshihiro Komohara
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166680 (2016)
The immune status of patients can impact on the clinical course of cancer. Lymph node (LN) macrophages play critical roles in anti-cancer immunity via the activation of cytotoxic T-lymphocytes (CTLs). In this study, the prognostic significance of CD1
Externí odkaz:
https://doaj.org/article/424051c0c40f416db6733e29fb014d7c
Autor:
Yoichiro Kaku, Haruki Imaoka, Yoshitaka Morimatsu, Yoshihiro Komohara, Koji Ohnishi, Hanako Oda, Shinichi Takenaka, Masanobu Matsuoka, Tomotaka Kawayama, Motohiro Takeya, Tomoaki Hoshino
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87400 (2014)
We have previously reported that the lungs of patients with very severe chronic obstructive pulmonary disease (COPD) contain significantly higher numbers of alveolar macrophages than those of non-smokers or smokers. M1 and M2 macrophages represent pr
Externí odkaz:
https://doaj.org/article/2f2f291802e440a29245e76adad6833c
Autor:
Yoichi Saito, Yukio Fujiwara, Yuji Miyamoto, Koji Ohnishi, Yuta Nakashima, Yasuhiko Tabata, Hideo Baba, Yoshihiro Komohara
Publikováno v:
Cancer Medicine. 12:10199-10211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa49c22a833784bc91b42de671f5967
https://doi.org/10.1002/cam4.5747
https://doi.org/10.1002/cam4.5747
Autor:
Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy J.Y. Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, Feng Wei, Lingfeng Fu, Jun Zhang, Fumimasa Kitamura, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Hirotake Tsukamoto, Terumasa Umemoto, Mari Masuda, Osamu Nagano, Yorifumi Satou, Hideyuki Saya, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Publikováno v:
Cancer Research. 83:753-770
Excess stroma and cancer-associated fibroblasts (CAF) enhance cancer progression and facilitate immune evasion. Insights into the mechanisms by which the stroma manipulates the immune microenvironment could help improve cancer treatment. Here, we aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1009c6fac1d9909e2a316434917b067
https://doi.org/10.1158/0008-5472.can-22-1890
https://doi.org/10.1158/0008-5472.can-22-1890
CXCL10 Expression in Human Colorectal Cancer Tissue and its Correlation With Serum Levels of CXCL10.
Autor:
LIANBO LI, KOSUKE KANEMITSU, KOJI OHNISHI, RIN YAMADA, HIROMU YANO, YUKIO FUJIWARA, YUJI MIYAMOTO, YOSHIKI MIKAMI, TAIZO HIBI, HIDEO BABA, YOSHIHIRO KOMOHARA
Publikováno v:
Cancer Genomics & Proteomics (1109-6535); Jan/Feb2024, Vol. 21 Issue 1, p54-64, 11p