Výsledky vyhledávání - "KO, Knockout"

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

Autor: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)

Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2-/- mice replicate the human phenotype but were n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291c
http://europepmc.org/articles/PMC8804273

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Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice

Autor: Mai Tu Dang, Carly I. Misztal, Iakov Efimenko, Matthew Villanueva, Lin Zhang, Kelly M. Dexter, Shiv Krishnaswamy, Malinda Gerard, Fumiaki Yokoi, Patrick Lynch, Yuqing Li

Publikováno v: IBRO Neuroscience Reports, Vol 11, Iss, Pp 1-7 (2021)
IBRO Neuroscience Reports

DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures. The majority of the DYT1 dystonia patients have a trinuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf995925b903998cc00bb08dddbee16d
http://www.sciencedirect.com/science/article/pii/S2667242121000233

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CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics

Autor: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

The 2020 Nobel Prize in Chemistry recognized CRISPR-Cas9, a super-selective and precise gene editing tool. CRISPR-Cas9 has an obvious advantage in editing multiple genes in the same cell, and presents great potential in disease treatment and animal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668a
http://www.sciencedirect.com/science/article/pii/S2211383521000113

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Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

Autor: Zhengcai Ju, Lin-shan Jiang, Xunjiang Wang, Wendong Huang, Zhengtao Wang, Siming Sun, Eryun Zhang, Lili Ding, Tong Tian, Qiaoling Yang, Li Yang, Yangmeng Wang, Yingbo Yang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1541-1554 (2021)
Acta Pharmaceutica Sinica. B

Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f45516d038bca9fd9338d0a4c987b9
http://www.sciencedirect.com/science/article/pii/S2211383521001106

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FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo

Autor: Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e5357537596081286716a9a13fac0
http://europepmc.org/articles/PMC8093479

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DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy

Autor: Min Xu, Fang Wang, Xiaoni Kong, Junzhe Jiao, Yueqiu Gao, Xuehua Sun, Hailong Wu, Jinyang Gu, Hualian Hang, Dongwei Xu, Jichang Li, Miao Huang

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 567-584 (2021)

Background & Aims DJ-1 is universally expressed in various tissues and organs and is involved in the physiological processes in various liver diseases. However, the role of DJ-1 in liver ischemia-reperfusion (I/R) injury is largely unknown. Methods I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a2bef2e703fa3d8ef38d5240ce768c
http://europepmc.org/articles/PMC8258983

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DAB2IP modulates primary cilia formation associated with renal tumorigenesis

Autor: Chun-Jung Lin, Jer Tsong Hsieh, Andrew Dang, Elizabeth Hernandez

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 169-180 (2021)
Neoplasia (New York, N.Y.)

Primary cilium is a microtubule-based organelle that projects from the surfaces of most mammalian cell types and protrudes into the extracellular milieu as an antenna-like sensor to senses extracellular physical and biochemical signals, and then tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361470a71f476fd73c328cb0a2367cb3
http://www.sciencedirect.com/science/article/pii/S1476558620301834

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Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis

Autor: Shanshan Zhang, Antonio Cigliano, Xianqiong Liu, Xinhua Song, Jie Zhang, Pan Wang, Yong Zeng, Xin Chen, Matthias Evert, Haichuan Wang, Ke Liu, Diego F. Calvisi, Jingxiao Wang, Hong Wu, Jiaoyuan Jia, Silvia Ribback, Li Che

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 4
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)

Background & Aims Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447d7bcd8df00ed9b5b307b5d9e85371
https://doi.org/10.1016/j.jcmgh.2020.11.008

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Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

Autor: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12cc853a36cd441fcfaf543a427312
http://www.sciencedirect.com/science/article/pii/S2352345X21001181

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Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNASummary

Autor: Jie Zan, Bi Wang, Xuya Zhao, Xiya Deng, Hongda Ding, Zijing Wei, Shuai Wang, Zhi Huang, Minyi Lu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 465-487 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Hepatocellular carcinoma (HCC) is the most common type of hepatic malignancies, with poor prognosis and low survival rate. Paraspeckles, which are unique subnuclear structures, are recently found to be involved in the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ab4ee8ec76c4cf013b60b95b4da027
http://www.sciencedirect.com/science/article/pii/S2352345X21000436

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