Zobrazeno 1 - 10
of 220
pro vyhledávání: '"KNOOK, DL"'
Autor:
Scherphof, GL, Romero, EL, Kamps, JAAM, Koning, GA, Meijer, DKF, Swart, P, Daemen, T, Wisse, E, Knook, DL, DeZanger, R, Fraser, R
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 7, 73-78
STARTPAGE=73;ENDPAGE=78;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 7
STARTPAGE=73;ENDPAGE=78;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 7
The architecture of the liver constitutes a favorable condition for cell-specific delivery of drugs by means of targeted delivery systems due to the presence of a fenestrated endothelium. This allows access of particulate drug carriers such as liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::4495fd5015bc4b1a6c937d075c7e9626
https://research.rug.nl/en/publications/69b4d2e9-64c3-493d-8169-65bdcef127bd
https://research.rug.nl/en/publications/69b4d2e9-64c3-493d-8169-65bdcef127bd
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 6, 187-190
STARTPAGE=187;ENDPAGE=190;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
STARTPAGE=187;ENDPAGE=190;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
Increased expression of alkaline phosphatase (AP) in the liver is a hallmark of cholestasis but the pathophysiological role of this is not clear. We argue that deprotonation of carboxyl groups at the active site of the enzyme may be a prerequisite fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::d188ff8c18de759e50f0024733d584c0
https://research.rug.nl/en/publications/09fd49d5-a92a-41af-9ee7-a40d67bddc00
https://research.rug.nl/en/publications/09fd49d5-a92a-41af-9ee7-a40d67bddc00
Autor:
Kamps, JAAM, Morselt, HWM, Swart, PJ, Meijer, DKF, Scherphof, GL, Wisse, E, Knook, DL, Balabaud, C
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 6, 387-388
STARTPAGE=387;ENDPAGE=388;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
STARTPAGE=387;ENDPAGE=388;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) was covalently coupled to liposomes (Aco-HSA-Lip). Aco-HSA-Lip were cleared from the blood and taken up by the liver within 30 minutes after injection into a rat. In the live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::1dc1ac1f98fbaab85cdc5fe054c7dd05
https://research.rug.nl/en/publications/529f0d62-fce4-4655-9f41-3550db166c51
https://research.rug.nl/en/publications/529f0d62-fce4-4655-9f41-3550db166c51
Autor:
Beljaars, E, Vos, TA, Poelstra, K, Molema, G, Jansen, PLM, Meijer, DKF, Moshage, H, Wisse, E, Knook, DL, Balabaud, C
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 6, 32-33
STARTPAGE=32;ENDPAGE=33;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
STARTPAGE=32;ENDPAGE=33;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
Increased expression of the enzyme inducible Nitric Oxide Synthase (iNOS) has been observed in models of acute liver inflammation. Since in recent reports an influence of Nitric Oxide radicals (NO) on fibrosis was proposed, we studied the hepatic exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::856187eddeb16967a759f3c9e1f48ab5
https://research.rug.nl/en/publications/6a244dad-f1db-45a8-b41c-e73afce418ad
https://research.rug.nl/en/publications/6a244dad-f1db-45a8-b41c-e73afce418ad
Autor:
Melgert, BN, Lebbe, C, Wartna, E, Molema, G, Poelstra, K, Albrecht, C, Reichen, J, Meijer, DKF, Wisse, E, Knook, DL, Balabaud, C
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 6, 389-390
STARTPAGE=389;ENDPAGE=390;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
STARTPAGE=389;ENDPAGE=390;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6
We have coupled the anti-inflammatory drug naproxen (Nap) covalently to human serum albumin (HSA) to deliver this drug selectively to non parenchymal cell types of the liver during endotoxin induced hepatic inflammation. Liver endothelial cells and K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::59fbeaad18a5603fc3edb0cf41028a7c
https://research.rug.nl/en/publications/2152177a-3045-4987-aac6-09f6c967a792
https://research.rug.nl/en/publications/2152177a-3045-4987-aac6-09f6c967a792
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 5, 29-32
STARTPAGE=29;ENDPAGE=32;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
STARTPAGE=29;ENDPAGE=32;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::2cd09a11d69ca8bc620248afa5df97eb
https://research.rug.nl/en/publications/57427f2a-fccf-4107-888f-75d8cf81674b
https://research.rug.nl/en/publications/57427f2a-fccf-4107-888f-75d8cf81674b
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 5, 130-133
STARTPAGE=130;ENDPAGE=133;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
STARTPAGE=130;ENDPAGE=133;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::8e369bf10d9b00e3a3098490c238da28
https://research.rug.nl/en/publications/f908e9c6-009d-4764-b0f1-c837db06bf15
https://research.rug.nl/en/publications/f908e9c6-009d-4764-b0f1-c837db06bf15
Publikováno v:
CELLS OF THE HEPATIC SINUSOID, VOL 5, 124-129
STARTPAGE=124;ENDPAGE=129;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
STARTPAGE=124;ENDPAGE=129;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::260e9bc541435415bc027a81dd53f7ca
https://research.rug.nl/en/publications/65329fbc-a62d-4c3a-90e7-8d9b3ce0363c
https://research.rug.nl/en/publications/65329fbc-a62d-4c3a-90e7-8d9b3ce0363c
Publikováno v:
Experimental cell research. 210(1)
Scavenger receptor-mediated processing by rat liver endothelial cells in vivo is studied by using acetylated and oxidized low-density lipoproteins (LDL) as ligands. The cellular localization of acetylated LDL (Ac-LDL) is visualized by both immunohist
Publikováno v:
Cells of the Hepatic Sinusoid, 4, 544-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::0c2319a91448544f81faa8f454e3305d
https://research.rug.nl/en/publications/c9055efc-3976-4bf4-b279-6be9253f4b61
https://research.rug.nl/en/publications/c9055efc-3976-4bf4-b279-6be9253f4b61