Aortic reservoir-excess pressure parameters are associated with worse cognitive function in people with untreated stage II/III hypertension.

Autor: Aizawa K; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Jordan AN; Department of Clinical and Biomedical Sciences.; University Hospitals Dorset, Poole.; NIHR Exeter Clinical Research Facility, Exeter., Gooding KM; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Llewellyn DJ; Department of Health and Community Sciences, University of Exeter Medical School, Exeter.; Alan Turing Institute, London., Mawson DM; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Casanova F; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Gates PE; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Adingupu DD; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Elyas S; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter.; Department of Healthcare for Older People, Royal Devon University Healthcare NHS Foundation Trust., Hope SV; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter.; Department of Healthcare for Older People, Royal Devon University Healthcare NHS Foundation Trust., Gilchrist M; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter., Strain WD; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter.; Department of Healthcare for Older People, Royal Devon University Healthcare NHS Foundation Trust., Clark CE; Department of Health and Community Sciences, University of Exeter Medical School, Exeter., Bellenger NG; Department of Cardiology, Royal Devon University Healthcare NHS Foundation Trust, Exeter., Sharp ASP; University Hospital of Wales, Cardiff., Parker KH; Department of Bioengineering, Imperial College., Hughes AD; MRC Unit for Lifelong Health & Ageing, Institute of Cardiovascular Science, University College London, London, UK., Shore AC; Department of Clinical and Biomedical Sciences.; NIHR Exeter Clinical Research Facility, Exeter.

Publikováno v: Journal of hypertension [J Hypertens] 2024 Dec 01; Vol. 42 (12), pp. 2139-2147. Date of Electronic Publication: 2024 Aug 29.

Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? Insights from post-hoc analysis of EXSCEL.

Autor: Gooding KM; Vascular Research Centre, University of Exeter Medical School, Barrack Road, Exeter, UK; NIHR Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust, Barrack Road, Exeter, UK. Electronic address: K.M.Gooding@exeter.ac.uk., Stevens S; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Lokhnygina Y; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Giczewska A; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Shore AC; Vascular Research Centre, University of Exeter Medical School, Barrack Road, Exeter, UK; NIHR Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust, Barrack Road, Exeter, UK., Holman RR; Diabetes Trials Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Publikováno v: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2024 Jun; Vol. 212, pp. 111685. Date of Electronic Publication: 2024 Apr 25.

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease.

Autor: Dwivedi OP; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Barreiro K; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, EV and HiPrep Core, University of Helsinki, Helsinki, Finland., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Hietalahdenkatu 2-4, 65130 Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Sepänkyläntie 14-16, 65100 Vaasa, Finland., Valo E; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Giri AK; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Foundation for the Finnish Cancer Institute (FCI), Tukholmankatu 8, 00290 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Prasad RB; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, SE 214 28 Malmö, Sweden., Roy RD; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Thorn LM; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Rannikko A; Research Program in Systems Oncology, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.; Department of Urology, 00014 University of Helsinki, and Helsinki University Hospital, 00100 Helsinki, Finland., Holthöfer H; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Gooding KM; Diabetes and Vascular Research Centre, National Institute for Health Research Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Sourbron S; Department of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK., Delic D; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.; Fifth Department of Medicine, Nephrology/Endocrinology/Rheumatology/Pneumology, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany., Gomez MF; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, SE 214 28 Malmö, Sweden., Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Diabetes, Central Clinical School Monash University, Melbourne, VIC, Australia., Tuomi T; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, SE 214 28 Malmö, Sweden.; Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland., Forsblom C; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Groop L; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, SE 214 28 Malmö, Sweden., Puhka M; Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, EV and HiPrep Core, University of Helsinki, Helsinki, Finland.

Publikováno v: IScience [iScience] 2023 Apr 18; Vol. 26 (5), pp. 106686. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis.

Autor: Khan F; Division of Systems Medicine, University of Dundee, Dundee, UK., Gonçalves I; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, Sweden., Shore AC; Diabetes and Vascular Medicine, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, UK., Natali A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Palombo C; Department of Surgical, Medical, Molecular, and Critical Area Pathology, University of Pisa, Pisa, Italy., Colhoun HM; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Östling G; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Casanova F; Diabetes and Vascular Medicine, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, UK., Kennbäck C; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Aizawa K; Diabetes and Vascular Medicine, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, UK., Persson M; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Gooding KM; Diabetes and Vascular Medicine, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, UK., Strain D; Diabetes and Vascular Medicine, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, UK., Looker H; Division of Systems Medicine, University of Dundee, Dundee, UK., Dove F; Division of Systems Medicine, University of Dundee, Dundee, UK., Belch J; Division of Systems Medicine, University of Dundee, Dundee, UK., Pinnola S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Venturi E; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Kozakova M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; Department of Surgical, Medical, Molecular, and Critical Area Pathology, University of Pisa, Pisa, Italy., Nilsson J; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden. Electronic address: jan.nilsson@med.lu.se.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2022 Jul 19; Vol. 3 (7), pp. 100676.

Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals With Type 2 Diabetes.

Autor: Aizawa K; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Casanova F; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Gates PE; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Mawson DM; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Gooding KM; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Strain WD; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Östling G; Department of Clinical Sciences, Lund University, Malmö, Sweden (G.O., J.N.)., Nilsson J; Department of Clinical Sciences, Lund University, Malmö, Sweden (G.O., J.N.)., Khan F; Division of Molecular & Clinical Medicine, University of Dundee, United Kingdom (F.K.)., Colhoun HM; Centre for Genomic and Experimental Medicine, University of Edinburgh, United Kingdom (H.M.C.)., Palombo C; Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Italy (C.P.)., Parker KH; Department of Bioengineering, Imperial College, London, United Kingdom (K.H.P.)., Shore AC; Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, United Kingdom (K.A., F.C., P.E.G., D.M.M., K.M.G., W.D.S., A.C.S.)., Hughes AD; MRC Unit for Lifelong Health & Ageing, Institute of Cardiovascular Science, University College London, United Kingdom (A.D.H.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2021 Jul; Vol. 78 (1), pp. 40-50. Date of Electronic Publication: 2021 Jun 01.