Výsledky vyhledávání

Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats

Autor: Vos, TA, Gouw, ASH, Klok, PA, Havinga, R, vanGoor, H, Roelofsen, H, Kuipers, F, Jansen, PLM, Moshage, H

Publikováno v: Gastroenterology, 113(4), 1323-1333. W B SAUNDERS CO-ELSEVIER INC

Background & Aims: During endotoxemia, expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in the liver is increased, NO has been suggested to have a hepatoprotective function. The aim of this study was to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c8f62888b81767ac09b995132749c17c
https://research.rug.nl/en/publications/5fa40b67-2185-469f-b45f-9e802e0bd83d

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Systemic injection of products of activated neutrophils and H2O2 in myeloperoxidase-immunized rats leads to necrotizing vasculitis in the lungs and gut

Autor: Peter Heeringa, Foucher, P., Klok, Pa, Huitema, Mg, Tervaert, Jwc, Weening, Jj, Kallenberg, Cgm

Publikováno v: American journal of pathology, 151(1), 131-140. Elsevier Inc.
Web of Science
American Journal of Pathology, 151(1), 131-140. ELSEVIER SCIENCE INC

The strong association of anti-neutrophil cytoplasmic antibodies with various forms of systemic vasculitis suggests a role for these autoantibodies in the pathophysiology of systemic vasculitis. In the present study, we tested the hypothesis that rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d09c6683eb3e0cde413f5f6049451624
https://pure.amc.nl/en/publications/systemic-injection-of-products-of-activated-neutrophils-and-h2o2-in-myeloperoxidaseimmunized-rats-leads-to-necrotizing-vasculitis-in-the-lungs-and-gut(dd30f925-dc78-4326-aa06-c2ae1518ef15).html

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Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat

Autor: Peter Heeringa, Brouwer, E., Klok, Pa, Huitema, Mg, Vandenborn, J., Weening, Jj, Kallenberg, Cgm

Publikováno v: American Journal of Pathology, 149(5), 1695-1706. ELSEVIER SCIENCE INC
Web of Science
American Journal of Pathology, 149, pp. 1695-1706
American Journal of Pathology, 149, 5, pp. 1695-1706
American journal of pathology, 149(5), 1695-1706. Elsevier Inc.
American Journal of Pathology, 149, 1695-1706

Autoantibodies to myeloperoxidase (MPO) are present in sera from patients with various forms of vasculitis-associated glomerulonephritis. Evidence for a pathogenic role of anti-MPO antibodies has been provided mainly by in vitro studies. We studied t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4d6c37303c0f9256ad8bca89c59684d1
https://research.rug.nl/en/publications/85efc417-5baa-4950-8eeb-3277d52ecb30

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Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats

Autor: Heeringa, P, VanDenBorn, J, Brouwer, E, Dolman, KM, Klok, PA, Huitema, MG, Limburg, PC, Bakker, MAH, Berden, JHM, Daha, MR, Kallenberg, CGM

Publikováno v: Clinical and Experimental Immunology, 105(2), 321-329. Wiley

Elastase, but not PR3, induces proteinuria associated with loss of glomerular basement membrane (GEM) heparan sulphate after in vivo renal perfusion in rats. PR3 and elastase are cationic neutral serine proteinases present in the azurophilic granules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c6c7dafcf60adbd12ad6e72e7338377b
https://research.rug.nl/en/publications/589634a5-d05c-4123-aff0-09b04006b813

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