Zobrazeno 1 - 10
of 74
pro vyhledávání: '"KKXX"'
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background Cisd1 and Cisd2 proteins share very similar structures with an N-terminal membrane-anchoring domain and a C-terminal cytosolic domain containing an iron-cluster binding domain and ending with a C-terminal KKxx sequence. Despite sharing a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6905a97dbaf2ac763b2f4b28fbd32d4a
https://doaj.org/article/23585bef85894f8190cd7edb7acd3cf0
https://doaj.org/article/23585bef85894f8190cd7edb7acd3cf0
Autor:
Peter I. Mackenzie, Keiko Fujimoto, Akane Kimura, Shinji Takechi, Yoshitaka Tanaka, Yuji Ishii, Ken Kurohara, Madoka Esaki, Yuko Hirota, Yuu Miyauchi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:466-474
UDP-Glucuronosyltransferase (UGT) is a type I membrane protein localized to the endoplasmic reticulum (ER). UGT has a di-lysine motif (KKXX/KXKXX) in its cytoplasmic domain, which is defined as an ER retention signal. However, our previous study has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9648c2214588d94591a0ce12bf813a83
https://doi.org/10.1016/j.dmpk.2020.07.006
https://doi.org/10.1016/j.dmpk.2020.07.006
Autor:
Samo Roškar, Tina Fink, Arne Praznik, Nina Jerala, Jan Lonzarić, Nik Franko, Roman Jerala, Tjaša Plaper, Mojca Benčina
Publikováno v:
Nature communications. 13(1)
Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Protein secretion based on transcriptional control is rather slow, as proteins requires transcription, translation, followed by the transport from the end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19717d6271bae33fca0babd4cf8ef7b
https://pubmed.ncbi.nlm.nih.gov/35260576
https://pubmed.ncbi.nlm.nih.gov/35260576
Autor:
Peter I. Mackenzie, Keiko Fujimoto, Akane Kimura, Yuu Miyauchi, Yoshitaka Tanaka, Yuji Ishii, Sora Kimura, Yuko Hirota, Ken Kurohara
Publikováno v:
Molecular Pharmacology. 95:551-562
UDP-Glucuronosyltransferase (UGT) plays an important role in the metabolism of endogenous and exogenous compounds. UGT is a type I membrane protein, and has a dilysine motif (KKXX/KXKXX) in its C-terminal cytoplasmic domain. Although a dilysine motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c61356f1fb613223b0f8bd81560a89c
https://doi.org/10.1124/mol.118.113902
https://doi.org/10.1124/mol.118.113902
Publikováno v:
Journal of Virology
Porcine epidemic diarrhea virus (PEDV) causes high mortality in neonatal piglets. The PEDV spike (S) protein contains two intracellular sorting motifs, YxxΦ (tyrosine-based motif YEVF or YEAF) and KVHVQ at the cytoplasmic tail, yet their functions h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816b0475eba9299d21c63a75bac19dc0
https://pubmed.ncbi.nlm.nih.gov/30404797
https://pubmed.ncbi.nlm.nih.gov/30404797
Publikováno v:
Mycobiology
Eukaryotic cells contain a collection of spatially separated internal organelles embedded in the cytoplasm. Communication between these internal organelles is mediated by trafficking events that are mainly accomplished by vesicular transport. These t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099e7a57b8dd0af790915aa507ee3594
https://doi.org/10.5941/myco.2015.43.1.31
https://doi.org/10.5941/myco.2015.43.1.31
Autor:
Liwen Jiang, Byung-Ho Kang, Fernando Aniento, Yi Cai, Caiji Gao, Yejun Wang, David G. Robinson
Publikováno v:
Trends in Plant Science. 19:508-515
Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeaca739807daac8e1b974f06b88104
https://doi.org/10.1016/j.tplants.2014.04.004
https://doi.org/10.1016/j.tplants.2014.04.004
Enhanced secretion of a methyl parathion hydrolase in Pichia pastoris using a combinational strategy
Publikováno v:
Microbial Cell Factories
Although Pichia pastoris has been successfully used to produce various recombinant heterologous proteins, the efficiency varies. In this study, we used methyl parathion hydrolase (MPH) from Ochrobactrum sp. M231 as an example to study the effect of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddaf48fbfda2772abf71b9503f83dfac
https://doi.org/10.1186/s12934-015-0315-4
https://doi.org/10.1186/s12934-015-0315-4
Autor:
Jonathan Goldberg, Wenfu Ma
Publikováno v:
The EMBO Journal
Cytoplasmic dilysine motifs on transmembrane proteins are captured by coatomer α-COP and β'-COP subunits and packaged into COPI-coated vesicles for Golgi-to-ER retrieval. Numerous ER/Golgi proteins contain K(x)Kxx motifs, but the rules for their re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4d50df14ad3b023950ca99b82ec2fa
https://doi.org/10.1038/emboj.2013.41
https://doi.org/10.1038/emboj.2013.41
Autor:
Philip R. Evans, Lauren P. Jackson, Michael J. Lewis, Rainer Duden, Helen M. Kent, Melissa A. Edeling, David J. Owen
Publikováno v:
Developmental Cell
Summary COPI mediates retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) and within the Golgi stack, sorting transmembrane proteins bearing C-terminal KKxx or KxKxx motifs. The structure of KxKxx motifs bound to the N-terminal WD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f186b64c825a471343018f17620d2cb5
http://europepmc.org/articles/PMC3521961
http://europepmc.org/articles/PMC3521961