Zobrazeno 1 - 10
of 91
pro vyhledávání: '"KITHSIRI HERATH"'
Autor:
Lauren Girard, Kithsiri Herath, Hernando Escobar, Renate Reimschuessel, Olgica Ceric, Hiranthi Jayasuriya
Publikováno v:
Molecules, Vol 26, Iss 9, p 2449 (2021)
The U.S. Food and Drug Administration’s (FDA′s) Center for Veterinary Medicine (CVM) has been investigating reports of pets becoming ill after consuming jerky pet treats since 2007. Renal failure accounted for 30% of reported cases. Jerky pet tre
Externí odkaz:
https://doaj.org/article/8c4cc638a297418384e0926ade798cd6
Autor:
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2183-2195 (2015)
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor
Externí odkaz:
https://doaj.org/article/2172e3fff908429b99f72a94d0b8f239
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170721 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0164133.].
Externí odkaz:
https://doaj.org/article/a0c42ee3102d4affbbde67b225f02f09
Autor:
Seongah Han, Taro E. Akiyama, Stephen F. Previs, Kithsiri Herath, Thomas P. Roddy, Kristian K. Jensen, Hong-Ping Guan, Beth A. Murphy, Lesley A. McNamara, Xun Shen, Walter Strapps, Brian K. Hubbard, Shirly Pinto, Cai Li, Jing Li
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2615-2622 (2013)
Hepatic glucose overproduction is a major characteristic of type 2 diabetes. Because glucagon is a key regulator for glucose homeostasis, antagonizing the glucagon receptor (GCGR) is a possible therapeutic strategy for the treatment of diabetes melli
Externí odkaz:
https://doaj.org/article/1d1d5798fd99409895b2d79ffd6971d0
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164133 (2016)
Platensimycin (PTM) is a natural antibiotic produced by Streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase (FAS) without affecting synthesis of other lipids. Recently, we reported that oral administration of
Externí odkaz:
https://doaj.org/article/09d9a7eab4db484ba8f12a3152bad96d
Autor:
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1223-1231 (2012)
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mic
Externí odkaz:
https://doaj.org/article/6c63ed70b4314113b68773d0b93c3352
Autor:
Stephen F. Previs, Ablatt Mahsut, Alison Kulick, Keiana Dunn, Genevieve Andrews-Kelly, Christopher Johnson, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sheng-Ping Wang, Karim Azer, Jing Xu, Douglas G. Johns, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1420-1428 (2011)
The advantages of using 2H2O to quantify cholesterol synthesis include i) homogeneous precursor labeling, ii) incorporation of 2H via multiple pathways, and iii) the ability to perform long-term studies in free-living subjects. However, there are two
Externí odkaz:
https://doaj.org/article/ff2afdbb781d47b6b23bed7e3352c5b1
Autor:
David G. McLaren, Timothy He, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, Karen Gagen, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sloan Stribling, Andrew Taggart, Jason Imbriglio, Jinqi Liu, Dunlu Chen, Shirly Pinto, James M. Balkovec, Robert J. DeVita, Donald J. Marsh, Jose M. Castro-Perez, Alison Strack, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1150-1161 (2011)
The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to be gained from such studies is of partic
Externí odkaz:
https://doaj.org/article/d66b12300bbf4a1f976747589c656716
Autor:
Jose Castro-Perez, Stephen F. Previs, David G. McLaren, Vinit Shah, Kithsiri Herath, Gowri Bhat, Douglas G. Johns, Sheng-Ping Wang, Lyndon Mitnaul, Kristian Jensen, Robert Vreeken, Thomas Hankemeier, Thomas P. Roddy, Brian K. Hubbard
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 159-169 (2011)
High resolution LC/MS-MS and LC/APPI-MS methods have been established for the quantitation of flux in the turnover of cholesterol and cholesterol ester. Attention was directed toward quantifying the monoisotopic mass (M0) and that of the singly deute
Externí odkaz:
https://doaj.org/article/c748fc80dd984745b02810b15b8a171d
Autor:
Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh, Olga Genilloud, Thomas P. Roddy, Stephen F. Previs, Ignacio González
Publikováno v:
Journal of Natural Products. 84:814-823
Natural product congeners serve a useful role in the understanding of natural product biosynthesis and structure-activity relationships. A minor congener with superior activity, selectivity, and modifiable functional groups could serve as a more effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12a7e9798a8198be4b1ea09ccc8b86
https://doi.org/10.1021/acs.jnatprod.0c01190
https://doi.org/10.1021/acs.jnatprod.0c01190