Zobrazeno 1 - 10
of 24
pro vyhledávání: '"KINGA SUBA"'
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Autor:
Aldara Martin Alonso, Simon C. Cork, Phyllis Phuah, Benjamin Hansen, Mariana Norton, Sijing Cheng, Xiang Xu, Kinga Suba, Yue Ma, Georgina KC. Dowsett, John A. Tadross, Brian YH. Lam, Giles SH. Yeo, Herbert Herzog, Stephen R. Bloom, Myrtha Arnold, Walter Distaso, Kevin G. Murphy, Victoria Salem
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101895- (2024)
Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its the
Externí odkaz:
https://doaj.org/article/8ca434c5412d4079a5b6bb6f4eff13e9
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell f
Externí odkaz:
https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e
Autor:
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford JB Briant
Publikováno v:
eLife, Vol 10 (2021)
Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon. Varying glucose over the range of concentrations that oc
Externí odkaz:
https://doaj.org/article/706e44ec35864e4a845aaa9f2824dfba
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c286f4e96f8148e0ae12a0a2035467e5
Autor:
Stavroula Bitsi, Liliane El Eid, Yusman Manchanda, Affiong I. Oqua, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A. Rutter, Victoria Salem, Ben Jones, Alejandra Tomas
Publikováno v:
Science Advances. 9
The glucagon-like peptide-1 receptor (GLP-1R) is a major type 2 diabetes therapeutic target. Stimulated GLP-1Rs are rapidly desensitized by β-arrestins, scaffolding proteins that not only terminate G protein interactions but also act as independent
Autor:
Walter Distaso, Mohammad M.A.H. Malik, Saba Semere, Amal AlHakami, Emma C. Alexander, Dhruti Hirani, Ronak J. Shah, Kinga Suba, Vicky McKechnie, Ana Nikčević, Nick Oliver, Marcantonio Spada, Victoria Salem
Publikováno v:
Diabetic Medicine. 39
The effects of the COVID-19 pandemic on mental health have been profound. Mental health and diabetes self-care are inter-related. We examined whether COVID-19 anxiety, depressive symptoms and health anxiety were associated with domains of diabetes se
Autor:
KINGA SUBA, YATEEN S. PATEL, ANNA ROBERTS, JED V. SHREWSBURY, SHIQIAN CHEN, RACHEL KWOK, VASILIKI KALOGIANNI, XIAOXUAN LIU, GUY A. RUTTER, BEN JONES, TRICIA M. TAN, BRYN OWEN, DANIEL J. DRUCKER, STEPHEN BLOOM, KEVIN MURPHY, VICTORIA SALEM
Publikováno v:
Diabetes. 71
Background: Type 2 diabetes (T2D) is characterised by the loss of pulsatile insulin secretion. We studied mice with β-cell specific loss of the glucagon receptor (GCGRflox/flox X Ins-1 cre) , to investigate the role of intra-islet glucagon signallin
Autor:
Stavroula Bitsi, Yusman Manchanda, Liliane ElEid, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A. Rutter, Victoria Salem, Ben Jones, Alejandra Tomas
The glucagon-like peptide-1 receptor (GLP-1R) is a major therapeutic target in type 2 diabetes (T2D) and obesity. Following activation, GLP-1Rs are rapidly desensitised by β-arrestins, scaffolding proteins that terminate G protein interactions but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54864b84cea635fadb6d75807be2eb2
https://doi.org/10.1101/2022.04.21.489075
https://doi.org/10.1101/2022.04.21.489075
Autor:
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford JB Briant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2aa125ca58a5cadb1c6c7a9647fc64
https://doi.org/10.7554/elife.72919.sa2
https://doi.org/10.7554/elife.72919.sa2
Autor:
Kinga Suba, Victoria Salem, Guy A. Rutter, Elina Akalestou, Asger Wretlind, Eleni Georgiadou, Isabelle Leclerc, Pauline Chabosseau, Alasdair Gallie, Livia Lopez-Noriega, Cristina Legido-Quigley
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this st