Zobrazeno 1 - 10
of 2 009
pro vyhledávání: '"KIM-1"'
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Polymyxins have been revived as a last-line therapeutic option for multi-drug resistant bacteria and continue to account for a significant proportion of global antibiotic usage. However, kidney injury is often a treatment limiting
Externí odkaz:
https://doaj.org/article/8c26cb5db8fe426085246ffc90d1daeb
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 4, Pp 448-462 (2024)
INTRODUCTION. The determination of nephrotoxicity markers is a useful and necessary step in the detection of renal injury in animal experiments; these markers help accurately localise organ damage. With multiple damaging agents, known nephrotoxicity
Externí odkaz:
https://doaj.org/article/53d85317f6654e4db4c4d6e44419c5c7
Autor:
Sophia L. Samodelov, Zhibo Gai, Francesca De Luca, Klara Haldimann, Sven N. Hobbie, Daniel Müller, Gerd A. Kullak-Ublick, Michele Visentin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Colistin is a polymyxin antibiotic currently experiencing renewed clinical interest due to its efficacy in the treatment of multidrug resistant (MDR) bacterial infections. The frequent onset of acute dose-dependent kidney injury, with the po
Externí odkaz:
https://doaj.org/article/a51caf5e8b014775b1788ea24ca7f003
Autor:
Ping Yu, Tanwei Gu, Yueyang Rao, Weimin Liang, Xi Zhang, Huanguo Jiang, Jindi Lu, Jianglian She, Jianmin Guo, Wei Yang, Yonghong Liu, Yingfeng Tu, Lan Tang, Xuefeng Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3232-3250 (2024)
Insufficient therapeutic strategies for acute kidney injury (AKI) necessitate precision therapy targeting its pathogenesis. This study reveals the new mechanism of the marine-derived anti-AKI agent, piericidin glycoside S14, targeting peroxiredoxin 1
Externí odkaz:
https://doaj.org/article/d25b34968aac42819ebddcb13d0f09a5
Autor:
Nermine Nabil Mahfouz, Azza Abd El-Shaheed, Sara Fawzy Sallam, Rehab Selim Ismail Moustafa, Salwa Refaat El-Zayat, Hiba Sibaii
Publikováno v:
Journal of Clinical and Basic Research, Vol 8, Iss 2, Pp 17-19 (2024)
Background: The onset of obesity-associated renal injury is insidious and asymptomatic. Therefore, finding an early marker will be extremely useful in its detection. Kidney injury molecule-1 (KIM-1) can be evaluated as an early marker for renal injur
Externí odkaz:
https://doaj.org/article/1499f8fd73ac40868cdc4e5cd86c19ee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Diabetic nephropathy represents one of the main long-term complications in T2DM patients. Cigarette smoking represents one of modifiable renal risk factors to kidney damage due to lead (Pb) exposure in these patients. Our goal is to investig
Externí odkaz:
https://doaj.org/article/572633febe4d456eb423c8f4bfa04d73
Publikováno v:
Revista Científica, Vol 34, Iss 2 (2024)
Advanced age, called geriatrics, negatively affects the aging–related physiological changes on bodysystems. non–steroidal anti–inflammatory drugs (NSAIDs) used in geriatric pets or humans have negative effects on the kidneys. For this purpose,
Externí odkaz:
https://doaj.org/article/70063f932e8044c5996282fa7a834691
Publikováno v:
Research and Reports in Urology, Vol Volume 16, Pp 65-78 (2024)
Rishabh Singh,1 James C Watchorn,2 Alexander Zarbock,3 Lui G Forni4,5 1Department of Surgery, Royal Surrey Hospital, Guildford, Surrey, UK; 2Intensive Care Unit, Royal Berkshire NHS Foundation Trust, Reading, Berkshire, UK; 3Department of Anesthesiol
Externí odkaz:
https://doaj.org/article/355dd4dd034e4b0d810eb0240140821e
Autor:
Jonathan G. Amatruda, Ronit Katz, Casey M. Rebholz, Mark J. Sarnak, Orlando M. Gutierrez, Sarah J. Schrauben, Jason H. Greenberg, Josef Coresh, Mary Cushman, Sushrut Waikar, Chirag R. Parikh, Jeffrey R. Schelling, Manasi P. Jogalekar, Joseph V. Bonventre, Ramachandran S. Vasan, Paul L. Kimmel, Joachim H. Ix, Michael G. Shlipak
Publikováno v:
Kidney Medicine, Vol 6, Iss 6, Pp 100834- (2024)
Rationale & Objective: Tubulointerstitial damage is a feature of early chronic kidney disease (CKD), but current clinical tests capture it poorly. Urine biomarkers of tubulointerstitial health may identify risk of CKD. Study Design: Prospective cohor
Externí odkaz:
https://doaj.org/article/6c30c18def6e45a6aa01ef19841e1239
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionChronic hyperglycemia-induced oxidative stress plays a crucial role in the development of diabetic nephropathy (DN). Moreover, adverse extracellular matrix (ECM) accumulation elevates renal resistive index leading to progressive worsening
Externí odkaz:
https://doaj.org/article/dfc76c6172d743ae80efc2f2d09fb6fa