Zobrazeno 1 - 10
of 77
pro vyhledávání: '"KIF21B"'
Publikováno v:
Open Medicine, Vol 17, Iss 1, Pp 253-265 (2022)
In this study, we intended to figure out the biological significance of long non-coding RNAs (lncRNAs) solute carrier organic anion transporter family member 4A1 antisense RNA 1 (SLCO4A1-AS1) in pancreatic cancer (PC). Cell counting kit-8, colony for
Externí odkaz:
https://doaj.org/article/e08b50d9ddb84cb59922eddbb19a4e64
Kif21B mediates the effect of estradiol on the morphological plasticity of mouse hippocampal neurons
Autor:
Danny Ganchala, Daniel Pinto-Benito, Elisa Baides, Isabel Ruiz-Palmero, Daniela Grassi, Maria Angeles Arevalo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionNeurons are polarized cells, and their ability to change their morphology has a functional implication in the development and plasticity of the nervous system in order to establish new connections. Extracellular factors strongly influence
Externí odkaz:
https://doaj.org/article/4827467b65c2439e8e8fd9a584d75cea
Autor:
Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta
Publikováno v:
eLife, Vol 11 (2022)
Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations of kinesin-4 cause several diseases,
Externí odkaz:
https://doaj.org/article/7e036509e52e42ebb8bcf2b69ed29cfd
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Kinesin superfamily proteins (KIFs) serve as microtubule-dependent molecular motors, and are involved in the progression of many malignant tumors. In this study, we aimed to investigate the expression pattern and precise role of k
Externí odkaz:
https://doaj.org/article/356a750cb8244a849af147c1cd2c92aa
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Osteosarcoma (OS) is the most common malignancy that occurs mainly during childhood and adolescence; however, no clear molecular or biological mechanism has been identified. In this study, we aimed to explore new biomarkers for the early diagnosis, t
Externí odkaz:
https://doaj.org/article/d8b27057780a43a9a093b8334e032163
Autor:
Kira V. Gromova, Mary Muhia, Nicola Rothammer, Christine E. Gee, Edda Thies, Irina Schaefer, Sabrina Kress, Manfred W. Kilimann, Olga Shevchuk, Thomas G. Oertner, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2705-2717 (2018)
Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synapti
Externí odkaz:
https://doaj.org/article/ca348ec380c54b27b6fa8ba02855ace0
Autor:
Mary Muhia, Edda Thies, Dorthe Labonté, Amy E. Ghiretti, Kira V. Gromova, Francesca Xompero, Corinna Lappe-Siefke, Irm Hermans-Borgmeyer, Dietmar Kuhl, Michaela Schweizer, Ora Ohana, Jürgen R. Schwarz, Erika L.F. Holzbaur, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 968-977 (2016)
The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF2
Externí odkaz:
https://doaj.org/article/fe8a1afb790842fab33b17605daed690
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Wilhelmina E van Riel, Ankit Rai, Sarah Bianchi, Eugene A Katrukha, Qingyang Liu, Albert JR Heck, Casper C Hoogenraad, Michel O Steinmetz, Lukas C Kapitein, Anna Akhmanova
Publikováno v:
eLife, Vol 6 (2017)
Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus end
Externí odkaz:
https://doaj.org/article/6f94d5e6bfaf4dc0957d5bb79b6a6008