Zobrazeno 1 - 10
of 42
pro vyhledávání: '"KI Maijer"'
Autor:
Monika Hansson, Paul P. Tak, Matthijs Janssen, M. Starmans-Kool, Niek de Vries, Aeilko H. Zwinderman, Man Wai Tang, M Safy, KI Maijer, Danielle M. Gerlag, Sander W. Tas, Maria J. H. de Hair, Astrid van Tubergen
Publikováno v:
Annals of the Rheumatic Diseases, 78(2), 179-185. BMJ Publishing Group
Annals of the Rheumatic Diseases
Annals of the rheumatic diseases, 78(2), 179-185. BMJ Publishing Group
Annals of the Rheumatic Diseases
Annals of the rheumatic diseases, 78(2), 179-185. BMJ Publishing Group
ObjectivesWe explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis develo
Autor:
Leonard J van Boven, Danielle M. Gerlag, TH Ramwadhdoebe, Lisa G. M. van Baarsen, Paul P. Tak, J Hähnlein, KI Maijer
Publikováno v:
European Journal of Immunology
European journal of immunology, 46(12), 2812-2821. Wiley-VCH Verlag
European journal of immunology, 46(12), 2812-2821. Wiley-VCH Verlag
The balance between proinflammatory and regulatory CD4(+) T cells is tightly controlled in lymphoid organs. In autoimmune diseases this balance is altered in the periphery and target tissue of patients. However, not much is known about the balance in
Autor:
KI Maijer, K.P. van Lienden, M I Ramos, L G M van Baarsen, Paul P. Tak, M C Lebre, TH Ramwadhdoebe, M. Maas, Danielle M. Gerlag
Publikováno v:
Cells, Vol 8, Iss 7, p 756 (2019)
Cells, 8(7). MDPI Multidisciplinary Digital Publishing Institute
Cells
Volume 8
Issue 7
Cells, 8(7). MDPI Multidisciplinary Digital Publishing Institute
Cells
Volume 8
Issue 7
Lymph nodes (LNs) are highly organized structures where specific immune responses are initiated by dendritic cells (DCs). We investigated the frequency and distribution of human myeloid (mDCs) and plasmacytoid (pDCs) in LNs and blood during the earli
Autor:
Danielle M. Gerlag, Sander W. Tas, Paul P. Tak, Maria J. H. de Hair, KI Maijer, Christiaan van der Leij, Mario Maas, Cristina Lavini
Publikováno v:
Arthritis & Rheumatology. 68:587-596
Objective. Analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using pharmacokinetic modeling (PKM) provides quantitative measures that mirror microvessel integrity and can be used as an objective marker of the level of synovia
Autor:
J Hähnlein, Danielle M. Gerlag, Tineke de Jong, Reza Nadafi, KI Maijer, Lisa G. M. van Baarsen, TH Ramwadhdoebe, Reina E. Mebius, Paul P. Tak, Ijsbrand A.J. Zijlstra, Mario Maas, JF Semmelink, Teunis B. H. Geijtenbeek
Publikováno v:
Arthritis Research & Therapy
Arthritis research & therapy, 20(1). BioMed Central
Hähnlein, J S, Nadafi, R, de Jong, T, Ramwadhdoebe, T H, Semmelink, J F, Maijer, K I, Zijlstra, I J A, Maas, M, Gerlag, D M, Geijtenbeek, T B H, Tak, P P, Mebius, R E & van Baarsen, L G M 2018, ' Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis ', Arthritis Research & Therapy, vol. 20, no. 1, 35 . https://doi.org/10.1186/s13075-018-1529-8, https://doi.org/10.1186/s13075-018-1529-8
Arthritis Research & Therapy, 20(1):35. BioMed Central
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-12 (2018)
Arthritis research & therapy, 20(1). BioMed Central
Hähnlein, J S, Nadafi, R, de Jong, T, Ramwadhdoebe, T H, Semmelink, J F, Maijer, K I, Zijlstra, I J A, Maas, M, Gerlag, D M, Geijtenbeek, T B H, Tak, P P, Mebius, R E & van Baarsen, L G M 2018, ' Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis ', Arthritis Research & Therapy, vol. 20, no. 1, 35 . https://doi.org/10.1186/s13075-018-1529-8, https://doi.org/10.1186/s13075-018-1529-8
Arthritis Research & Therapy, 20(1):35. BioMed Central
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-12 (2018)
Background Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses through their intimate connec
Autor:
Mario Maas, KI Maijer, Ae Ri Noort, Paul P. Tak, Danielle M. Gerlag, Maria J.H. de Hair, Sander W. Tas, IY Choi, Christiaan van der Leij, Katinka P.M. van Zoest
Publikováno v:
Journal of rheumatology, 42(9), 1573-1581. Journal of Rheumatology
Objective.The nuclear factor-κB (NF-κB) family of transcription factors is strongly involved in synovial inflammation. We have previously shown that NF-κB–inducing kinase (NIK) is a key regulator of inflammation-induced angiogenesis in rheumatoi
Publikováno v:
Arthritis & Rheumatology. 67:3324-3326
Autor:
Monique A.J. Janssen, L. Klareskog, S. Eyre, A. van Tubergen, N. de Vries, K. Zwinderman, Danielle M. Gerlag, M. Starmans-Kool, KI Maijer, M Safy, PP Tak, TH Ramwadhdoebe, Sander W. Tas
Publikováno v:
Poster Presentations.
Background Exploration of the mechanism underlying the delay of development of clinical signs of seropositive rheumatoid arthritis (RA) observed after B cell directed therapy in individuals at risk of developing autoantibody positive RA may offer ins
Publikováno v:
Annals of the Rheumatic Diseases
Annals of the rheumatic diseases, 74(11), 2097-2099. BMJ Publishing Group
Annals of the rheumatic diseases, 74(11), 2097-2099. BMJ Publishing Group
The 2010 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) updated classification criteria for rheumatoid arthritis (RA) focus on identifying patients at early disease stage.1 They facilitate early implementation of
Autor:
Paul P. Tak, Danielle M. Gerlag, Anne-Christine Bay-Jensen, Natasja Stæhr Gudmann, Morten A. Karsdal, KI Maijer
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149329 (2016)
Maijer, K I, Gudmann, N S, Karsdal, M A, Gerlag, D M, Tak, P P & Bay-Jensen, A C 2016, ' Neo-Epitopes—Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis ', PLoS ONE, vol. 11, no. 3, e0149329 . https://doi.org/10.1371/journal.pone.0149329
PLoS ONE, 11(3). Public Library of Science
PLoS ONE
Maijer, K I, Gudmann, N S, Karsdal, M A, Gerlag, D M, Tak, P P & Bay-Jensen, A C 2016, ' Neo-Epitopes—Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis ', PLoS ONE, vol. 11, no. 3, e0149329 . https://doi.org/10.1371/journal.pone.0149329
PLoS ONE, 11(3). Public Library of Science
PLoS ONE
OBJECTIVE: Tissue destruction in rheumatoid arthritis (RA) is predominantly mediated by matrix metalloproteinases (MMPs), thereby generating protein fragments. Previous studies have revealed that these fragments include MMP-mediated collagen type I,