Výsledky vyhledávání - "KH Weisgraber"

Akademický článek

A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder

Autor: TP Bersot, SJ Russell, SR Thatcher, NK Pomernacki, RW Mahley, KH Weisgraber, TL Innerarity, CS Fox

Publikováno v: Journal of Lipid Research, Vol 34, Iss 7, Pp 1149-1154 (1993)

The prevalence of familial defective apolipoprotein (apo) B-100 (FDB) was determined by sampling 5,160 volunteer subjects from among 14,058 eligible employees of a bank in California. The sample was ethnically diverse (44.6% of the population was non

Externí odkaz: https://doaj.org/article/69efb2936b7c417da6c76e631d24d678

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Akademický článek

Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.

Autor: S Fazio, Y Horie, KH Weisgraber, LM Havekes, SC Rall, Jr

Publikováno v: Journal of Lipid Research, Vol 34, Iss 3, Pp 447-453 (1993)

Apolipoprotein (apo) E Leiden is a rare variant of human apoE characterized by defective receptor binding and associated with dominant transmission of type III hyperlipoproteinemia. In heterozygotes, apoE Leiden is present in higher concentrations in

Externí odkaz: https://doaj.org/article/0054c4cc8356490e930c89d719f2dc99

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Akademický článek

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.

Autor: GE Handelmann, JK Boyles, KH Weisgraber, RW Mahley, RE Pitas

Publikováno v: Journal of Lipid Research, Vol 33, Iss 11, Pp 1677-1688 (1992)

Previous studies suggest that during nerve regeneration apoE acts as a lipid transport protein that assists in the rapid initial extension of axons and then in their myelination. To determine whether apoE and/or apoE-containing lipoproteins can modul

Externí odkaz: https://doaj.org/article/bfbe9289884249738d0a9ca4e17fa40c

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Akademický článek

Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity

Autor: MR Wardell, SC Rall, Jr, EJ Schaefer, JP Kane, KH Weisgraber

Publikováno v: Journal of Lipid Research, Vol 32, Iss 3, Pp 521-528 (1991)

Apolipoprotein (apo) E polymorphism has a significant effect on plasma cholesterol and low density lipoprotein cholesterol concentrations. The association of two apoE5 isoforms with elevated plasma low density lipoprotein cholesterol levels in two un

Externí odkaz: https://doaj.org/article/b52536dfc161449397674e19936298c5

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Akademický článek

Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.

Autor: TL Innerarity, RW Mahley, KH Weisgraber, TP Bersot, RM Krauss, GL Vega, SM Grundy, W Friedl, J Davignon, BJ McCarthy

Publikováno v: Journal of Lipid Research, Vol 31, Iss 8, Pp 1337-1349 (1990)

Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to

Externí odkaz: https://doaj.org/article/e84507283cdb4cfaabfc4a320d3b82e2

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Akademický článek

Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.

Autor: M R Wardell, SC Rall, Jr, SO Brennan, ER Nye, PM George, ED Janus, KH Weisgraber

Publikováno v: Journal of Lipid Research, Vol 31, Iss 3, Pp 535-543 (1990)

Homozygosity for the apolipoprotein (apo) E variant apoE2(158 Arg—-Cys) invariably gives rise to dysbetalipoproteinemia, and when associated with obesity or a gene for hyperlipidemia, results in type III hyperlipoproteinemia. The association of the

Externí odkaz: https://doaj.org/article/87235570022e42c2becaa2230800b82f

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