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Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients

Autor: Daniel B. Larach, Adam Lewis, Lisa Bastarache, Anita Pandit, Jing He, Anik Sinha, Nicholas J. Douville, Michael Heung, Michael R. Mathis, Jonathan D. Mosley, Jonathan P. Wanderer, Sachin Kheterpal, Matthew Zawistowski, Chad M. Brummett, Edward D. Siew, Cassianne Robinson-Cohen, Miklos D. Kertai

Publikováno v: BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)

Abstract Background Prior studies support a genetic basis for postoperative acute kidney injury (AKI). We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estimated the heritable com

Externí odkaz: https://doaj.org/article/813edc1012fa4c88a501d1fbf8d0c6be

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PeRiOperative Glucose PRAgMatic (PROGRAM) trial protocol and statistical analysis plan for comparing automated intraoperative reminders to standardise insulin administration in surgical patients at high risk of hyperglycaemia

Autor: Karen McCarthy, Robert E Freundlich, Matthew D McEvoy, Matthew S Shotwell, Svetlana Eden, Miklos D Kertai, Jonathan P Wanderer, Matthew Zapf, Dev Patel, Patrick Henson, Eunice Huang, Leslie Fowler

Publikováno v: BMJ Open, Vol 13, Iss 8 (2023)

Introduction Studies finding perioperative hyperglycaemia is associated with adverse patient outcomes in surgical procedures spurred the development of blood glucose guidelines at many institutions. In this trial, we will assess the implementation of

Externí odkaz: https://doaj.org/article/dd57f3a0d6e244fabb1f8e2d75195de9

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Suspected Simple Appendicitis in Children: Should We Use a Nonoperative, Antibiotic-Free Approach? An Observational Study

Autor: Patricia Reis Wolfertstetter, John Blanford Ebert, Judith Barop, Markus Denzinger, Michael Kertai, Hans J. Schlitt, Christian Knorr

Publikováno v: Children, Vol 11, Iss 3, p 340 (2024)

Background: Simple appendicitis may be self-limiting or require antibiotic treatment or appendectomy. The aim of this study was to assess the feasibility and safety of a nonoperative, antibiotic-free approach for suspected simple appendicitis in chil

Externí odkaz: https://doaj.org/article/6c17795f01b94549878fed95d49fe470

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Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury

Autor: Nicholas J. Douville, Daniel B. Larach, Adam Lewis, Lisa Bastarache, Anita Pandit, Jing He, Michael Heung, Michael Mathis, Jonathan P. Wanderer, Sachin Kheterpal, Ida Surakka, Miklos D. Kertai

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Background: The recent integration of genomic data with electronic health records has enabled large scale genomic studies on a variety of perioperative complications, yet genome-wide association studies on acute kidney injury have been limited in siz

Externí odkaz: https://doaj.org/article/6e9fe0d4416b4fc6be7ccf6f263fab07

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Simple Physical Process Can Slow Down the Progression of Cancer

Autor: Jozsef Garai, Pal Kertai

Publikováno v: SciMedicine Journal, Vol 4, Iss 1, Pp 39-45 (2022)

If a liquid contains suspended solids and flows out of a perforated pipe, the suspended particles of the right size can accumulate and eventually clog the openings. It is suggested that this physical process could be employed to effectively block the

Externí odkaz: https://doaj.org/article/379d64b1b5794648a94fdd44815a7126

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