Zobrazeno 1 - 10
of 345
pro vyhledávání: '"KERMIT L. CARRAWAY"'
Autor:
Michelle Hu, Ruiwu Liu, Noemi Castro, Liliana Loza Sanchez, Lapamas Rueankham, Julie A. Learn, Ruiqi Huang, Kit S. Lam, Kermit L. Carraway
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have the capacity to target tumor cell populations resistant to currently employed therapeutic agents. Howe
Externí odkaz:
https://doaj.org/article/e2c9d3c858cc4cc5b0a5666d7202c03c
Autor:
Kacey VanderVorst, Courtney A. Dreyer, Jason Hatakeyama, George R. R. Bell, Julie A. Learn, Anastasia L. Berg, Maria Hernandez, Hyun Lee, Sean R. Collins, Kermit L. Carraway
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-19 (2023)
Abstract Background In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to the treatment of advanc
Externí odkaz:
https://doaj.org/article/e905f750599d4911b712a3df4fed5973
Autor:
Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A. Dreyer, Xuyan Chen, Steven D. Quinn, Wei He, Matthew A. Coleman, Kermit L. Carraway, Bin Zhang, Gabriela S. Schlau-Cohen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
EGFR regulates cellular processes across the animal kingdom. Here, the authors show that transmembrane conformational coupling is the first step in EGFR signaling, providing evidence for the existence of transmembrane intramolecular conformational ch
Externí odkaz:
https://doaj.org/article/90a9162d54e04ceeb2e665ccb5f97ed2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The establishment of polarity within tissues and dynamic cellular morphogenetic events are features common to both developing and adult tissues, and breakdown of these programs is associated with diverse human diseases. Wnt/Planar cell polarity (Wnt/
Externí odkaz:
https://doaj.org/article/c44069e5686648068294c1311b90635d
Autor:
Michelle Hu, Kermit L. Carraway
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
A major confounding issue in the successful treatment of cancer is the existence of tumor cell populations that resist therapeutic agents and regimens. While tremendous effort has gone into understanding the biochemical mechanisms underlying resistan
Externí odkaz:
https://doaj.org/article/dad3e27932494ffcbe03e70c198a16eb
Autor:
Jin Zhang, Kermit L. Carraway
Publikováno v:
The Scientific World Journal, Vol 2, Pp 140-141 (2002)
Externí odkaz:
https://doaj.org/article/35eb812d3735462d885dc66b4bd2401e
Amiloride and its derivatives have long attracted attention as potential anticancer therapeutic agents. Several original studies characterized amilorides as inhibitors of sodium-proton antiporter tumor growth and urokinase plasminogen activator-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c844d09601c16a6b4ea93f92201220
https://doi.org/10.1101/2023.05.25.542364
https://doi.org/10.1101/2023.05.25.542364
Autor:
Colleen Sweeney, Kermit L. Carraway, Joe W. Gray, Obi L. Griffith, Lihong Qi, Lakmal Kotelawala, Hanine Rafidi, Will H.D. Fry, Jamie K. Miller, Catalina Simion, Seth Frietze, Sheryl R. Krig
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7329ecae6fd5b20e3768cfd41268e2
https://doi.org/10.1158/1541-7786.22519117
https://doi.org/10.1158/1541-7786.22519117
Autor:
Colleen Sweeney, Kermit L. Carraway, Joe W. Gray, Obi L. Griffith, Lihong Qi, Lakmal Kotelawala, Hanine Rafidi, Will H.D. Fry, Jamie K. Miller, Catalina Simion, Seth Frietze, Sheryl R. Krig
PDF file - 1.19MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc44158a30a355f52f473274641798e
https://doi.org/10.1158/1541-7786.22519129.v1
https://doi.org/10.1158/1541-7786.22519129.v1
Autor:
Colleen Sweeney, Kermit L. Carraway, Joe W. Gray, Obi L. Griffith, Lihong Qi, Lakmal Kotelawala, Hanine Rafidi, Will H.D. Fry, Jamie K. Miller, Catalina Simion, Seth Frietze, Sheryl R. Krig
Lrig1 is the founding member of the Lrig family and has been implicated in the negative regulation of several oncogenic receptor tyrosine kinases including ErbB2. Lrig1 is expressed at low levels in several cancer types but is overexpressed in some p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d281af8616267b2cab3cfb21ce810f
https://doi.org/10.1158/1541-7786.c.6542308
https://doi.org/10.1158/1541-7786.c.6542308