Zobrazeno 1 - 10
of 348
pro vyhledávání: '"KENTA KOBAYASHI"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 rec
Externí odkaz:
https://doaj.org/article/4822963dd51b44e69dd1546b20906230
Autor:
Kunihiro Azuma, Takafumi Suzuki, Kenta Kobayashi, Masako Nagahara, Hirotaka Imai, Akiko Suga, Takeshi Iwata, Tomoyasu Shiraya, Makoto Aihara, Takashi Ueta
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-12 (2024)
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models
Externí odkaz:
https://doaj.org/article/bd3beb598eb64000a5b3ab5cb93b582f
Autor:
Masahiro Mitsuhashi, Reona Yamaguchi, Toshinari Kawasaki, Satoko Ueno, Yiping Sun, Kaoru Isa, Jun Takahashi, Kenta Kobayashi, Hirotaka Onoe, Ryosuke Takahashi, Tadashi Isa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the role of interhemispheric pathway from the contralesional to ipsilesional premotor cor
Externí odkaz:
https://doaj.org/article/1b6bcb85086648e28ecb0b681dfcc717
Autor:
Teppei Ebina, Akitaka Sasagawa, Dokyeong Hong, Rieko Setsuie, Keitaro Obara, Yoshito Masamizu, Masashi Kondo, Shin-Ichiro Terada, Katsuya Ozawa, Masato Uemura, Masafumi Takaji, Akiya Watakabe, Kenta Kobayashi, Kenichi Ohki, Tetsuo Yamamori, Masanori Murayama, Masanori Matsuzaki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). To reveal PM- and M1-specific reorganization in a primate, we conducted calcium imaging in common marmosets while t
Externí odkaz:
https://doaj.org/article/7c710459480c402cbd4a10117bc17fa4
Autor:
Yasuyuki Osanai, Yao Lulu Xing, Shinya Mochizuki, Kenta Kobayashi, Jihane Homman-Ludiye, Amali Cooray, Jasmine Poh, Ayumu Inutsuka, Nobuhiko Ohno, Tobias D. Merson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101288- (2024)
Molecular cloning techniques enabling contemporaneous expression of two or more protein-coding sequences provide an invaluable tool for understanding the molecular regulation of cellular functions. The Cre-lox system is used for inducing the expressi
Externí odkaz:
https://doaj.org/article/58ba34fea2c24f2c9fe996aecdcdaad2
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The anterior cingulate cortex (ACC) responds to noxious and innocuous sensory inputs, and integrates them to coordinate appropriate behavioral reactions. However, the role of the projections of ACC neurons to subcortical areas and their infl
Externí odkaz:
https://doaj.org/article/e3b78fdd496d434487c9431f88ab1a7b
Autor:
Keitaro Obara, Teppei Ebina, Shin-Ichiro Terada, Takanori Uka, Misako Komatsu, Masafumi Takaji, Akiya Watakabe, Kenta Kobayashi, Yoshito Masamizu, Hiroaki Mizukami, Tetsuo Yamamori, Kiyoto Kasai, Masanori Matsuzaki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Although cortical feedback signals are essential for modulating feedforward processing, no feedback error signal across hierarchical cortical areas has been reported. Here, we observed such a signal in the auditory cortex of awake common mar
Externí odkaz:
https://doaj.org/article/0c7f82a62c9f42d1baf1c3a3a58ab429
Autor:
Yuichi Tsuchiya, Takao Seki, Kenta Kobayashi, Sachiko Komazawa-Sakon, Shigeyuki Shichino, Takashi Nishina, Kyoko Fukuhara, Kenichi Ikejima, Hidenari Nagai, Yoshinori Igarashi, Satoshi Ueha, Akira Oikawa, Shinya Tsurusaki, Soh Yamazaki, Chiharu Nishiyama, Tetuo Mikami, Hideo Yagita, Ko Okumura, Taketomo Kido, Atsushi Miyajima, Kouji Matsushima, Mai Imasaka, Kimi Araki, Toru Imamura, Masaki Ohmuraya, Minoru Tanaka, Hiroyasu Nakano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Liver fibrosis results from chronic liver injury triggered by factors such as viral infection, excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver fibrosis are not fully understood. Here, we demonstrate th
Externí odkaz:
https://doaj.org/article/634090b816f84d4c88ef880ddf06cc84
Autor:
Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 1-13 (2023)
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. There are l
Externí odkaz:
https://doaj.org/article/2eb99aaf89804103af13347c0cff9850
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract During offline brain states, such as sleep and memory consolidation, respiration coordinates hippocampal activity. However, the role of breathing during online memory traces remains unclear. Here, we show that respiration can be recruited du
Externí odkaz:
https://doaj.org/article/29cc6d70dbb74c63873dbce996a408f8