Zobrazeno 1 - 10
of 44
pro vyhledávání: '"KELLEDY MANSON"'
Autor:
Mark M. Awad, Ramaswamy Govindan, Kristen N. Balogh, David R. Spigel, Edward B. Garon, Meghan E. Bushway, Asaf Poran, Joong Hyuk Sheen, Victoria Kohler, Ekaterina Esaulova, John Srouji, Suchitra Ramesh, Rohit Vyasamneni, Binisha Karki, Tracey E. Sciuto, Himanshu Sethi, Jesse Z. Dong, Melissa A. Moles, Kelledy Manson, Michael S. Rooney, Zakaria S. Khondker, Mark DeMario, Richard B. Gaynor, Lakshmi Srinivasan
Publikováno v:
Cancer cell. 40(9)
Neoantigens arising from mutations in tumor DNA provide targets for immune-based therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a personalized neoantigen-vaccine NEO-PV-01 in combination with pemetrexed, carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935d29553f74594992b9744ac0684da4
https://pubmed.ncbi.nlm.nih.gov/36027917
https://pubmed.ncbi.nlm.nih.gov/36027917
Autor:
Lakshmi Srinivasan, Yvonne Ware, Kelledy Manson, Asaf Poran, Benjamin Trapp, Joel Greshock, Mark M. Awad, Dominik Barthelme, Dewi Harjanto, Victoria Kohler, Ying S. Ting, Richard B. Gaynor, Yuting Huang, Matthew D. Hellmann, Samantha J. Turnbull, Siwen Hu-Lieskovan, Ed Fritsch, Meghan E. Bushway, Jessica J. Lin, Lisa D. Cleary, Bartosz Chmielowski, Zhengping Huang, Michael S. Rooney, Terence W. Friedlander, Rana H. Besada, Patrick A. Ott, Zakaria S. Khondker, Mark DeMario, Kristen N. Balogh, Aung Naing, Melissa A. Moles, Riley R. Curran, Kim Margolin, Nina Bhardwaj, Tracey E. Sciuto, Jesse Z. Dong, Ramaswamy Govindan, Julian Scherer, Amy Wanamaker
Publikováno v:
Cell. 183(2)
Summary Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515738446c00429f62713aedbb493a4c
https://pubmed.ncbi.nlm.nih.gov/34781699
https://pubmed.ncbi.nlm.nih.gov/34781699
Autor:
Yue Sun, Valerie Philippon, Alicia Gomez-Yafal, Jenny G. Parvani, Norman L. Letvin, Phillip D. Markham, Michael S. Wyand, David C. Montefiori, Sampa Santra, Gail P. Mazzara, Dennis Panicali, Kelledy Manson
Publikováno v:
Journal of Virology. 81:8563-8570
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors. The present study was initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e37b35bd7c1de67ed5f69dcb3a51448
https://doi.org/10.1128/jvi.00744-07
https://doi.org/10.1128/jvi.00744-07
Autor:
Howard L. Kaufman, Ken Cheung, Kelledy Manson, Magalese Voulo, Julie Donovan, Joseph Divito, Dorota Moroziewicz, Karl S. Hurst-Wicker, Gail DeRaffele, David S. Lee, Dennis Panicali, Heidi Hörig, Seth Cohen, Josephine Mitcham, Kate Dolan, Francesco M. Marincola, Ena Wang
Publikováno v:
Journal of Clinical Investigation. 115:1903-1912
Immunotherapy for the treatment of metastatic melanoma remains a major clinical challenge. The melanoma microenvironment may lead to local T cell tolerance in part through downregulation of costimulatory molecules, such as B7.1 (CD80). We report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e3e2acc64f93f78280a7cf3b557bae
https://doi.org/10.1172/jci24624
https://doi.org/10.1172/jci24624
Autor:
Kimberly A. Zinnack, Norman L. Letvin, Kristin Beaudry, Alicia Gómez Yafal, Petr O. Ilyinskii, Dennis Panicali, Kelledy Manson, Shawn S. Jackson, Valerie Philippon, Marcelo J. Kuroda, Linda Gritz, Michelle A. Lifton, Gail P. Mazzara
Publikováno v:
Journal of Virology. 79:6554-6559
Poxvirus vaccine vectors, although capable of eliciting potent immune responses, pose serious health risks in immunosuppressed individuals. We therefore constructed five novel recombinant vaccinia virus vectors which contained overlapping deletions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9541e2a5eb8a75ac73a4c801a230912
https://doi.org/10.1128/jvi.79.10.6554-6559.2005
https://doi.org/10.1128/jvi.79.10.6554-6559.2005
Autor:
Ronald C. Montelaro, Jacqueline Gillis, Kelledy Manson, Kelly Stefano-Cole, Ussama M. Abdel-Motal, R. Paul Johnson, John D. Altman, Michael S. Wyand, David C. Montefiori
Publikováno v:
Virology. 333(2):226-238
The ability of memory T cells to mount a recall response plays a key role in the ability of vaccinated animals to contain viral challenge. In this study, we intensively monitored the expansion of SIV Gag-specific CD8+ T cells in peripheral blood and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d33c5f30e81d9eaae1c324a49ecda52
Autor:
Pamela A. Kozlowski, Lara Herrmann, Angela Carville, Anna Aldovini, Mike Piatak, R. Paul Johnson, Shainn Wei Wang, Frederic M.N. Bertley, Gail P. Mazzara, Keith G. Mansfield, Kelledy Manson
Publikováno v:
AIDS Research and Human Retroviruses. 20:846-859
We explored the use of a simian-human immunodeficiency virus (SHIV) DNA vaccine as an effective mucosal priming agent to stimulate a protective immune response for AIDS prevention. Rhesus macaques were vaccinated rectally with a DNA construct produci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b702c267503e36a3c83ca7796c594d
https://doi.org/10.1089/0889222041725253
https://doi.org/10.1089/0889222041725253
Autor:
David B. Weiner, Velpandi Ayyavoo, Dan Conway, Donghui Zhang, Daniel S. Hwang, Jean D. Boyer, Jong J. Kim, Kelledy Manson, Mark L. Bagarazzi, Karuppiah Muthumani
Publikováno v:
Journal of Medical Primatology. 31:179-185
We compared the immunogenicity of plasmid vaccines containing multiple human immunodeficiency virus (HIV) antigens and found that covaccination with plasmids expressing HIV-1 14 kDa vpr gene product profoundly reduces antigen-specific CD8-mediated cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb8f61df20d269207acf8329e6b7f27
https://doi.org/10.1034/j.1600-0684.2002.02004.x
https://doi.org/10.1034/j.1600-0684.2002.02004.x
Autor:
Kesen Dang, Liesl K. Nottingham, Joo-Sung Yang, David B. Weiner, Michael S. Wyand, Waixing Tang, Darren M. Wilson, J. Joseph Kim, Kelledy Manson
Publikováno v:
Oncogene. 20:4497-4506
Prostate specific antigen (PSA) is a widely used marker for prostate cancer, which is secreted by normal prostate cells at low levels, but is produced more substantially by cancer cells. We have previously reported on the use of a DNA vaccine constru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b98c9252638cc971a2bcb3b5c17198
https://doi.org/10.1038/sj.onc.1204542
https://doi.org/10.1038/sj.onc.1204542
Autor:
J. Joseph Kim, Kelledy Manson, Michael S. Wyand, Daniel J. Lee, Liesl K. Nottingham, Joo-Sung Yang, David B. Weiner, Jean D. Boyer, Kenneth E. Ugen, Mark H. Lee
Publikováno v:
Virology. 285(2):204-217
Multicomponent DNA vaccines were used to elicit immune responses, which can impact viral challenge in three separate rhesus macaque models. Eight rhesus macaques were immunized with DNA vaccines for HIV env/rev and SIV gag/pol and were challenged int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90ebab582dff985373d1f0a320d59