Výsledky vyhledávání - "KEITH T. MUIR"

An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction

Autor: Robert M. Wurm, Keith T. Muir, Lisa A St. John-Williams, Donavon J. McConn, Melinda J. Reese, Grant T. Generaux

Publikováno v: Drug Metabolism and Disposition. 36:1198-1201

There are documented clinical drug-drug interactions between bupropion and the CYP2D6-metabolized drug desipramine resulting in marked (5-fold) increases in desipramine exposure. This finding was unexpected as CYP2D6 does not play a significant role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817554c2d0e3b6e994ae64807c3eda5e
https://doi.org/10.1124/dmd.107.020198

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Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations

Autor: James W. Jefferson, James F. Pradko, Keith T. Muir

Publikováno v: Clinical Therapeutics. 27:1685-1695

Major depressive disorder (MDD) is a common psychiatric condition, with 6.6% of the adult population in the United States experiencing a major depressive episode during any given year. Depressed patients must receive adequate treatment to maximize th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1f5dd65f1ff86d15ace24507b6216b
https://doi.org/10.1016/j.clinthera.2005.11.011

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Pharmacokinetics of Remifentanil in Anesthetized Pediatric Patients Undergoing Elective Surgery or Diagnostic Procedures

Autor: Richard D. Stiller, Lynn Graham Henson, Brian Ginsberg, Keith T. Muir, Peter J. Davis, Allison Kinder Ross, Francis X. McGowan, Guy deL. Dear, Cameron Huffman

Publikováno v: Anesthesia & Analgesia. 93:1393-1401

PhD§*Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina; †Departments ofAnesthesiology and Pediatrics, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh, Pittsburgh,Pennsylvania; ‡

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a40350d5f0a94d53794d35153e883463
https://doi.org/10.1097/00000539-200112000-00008

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The electroencephalogram (EEG) and clinical measures of opioid potency: defining the EEG-clinical potency relationship (‘fingerprint’) with application to remifentanil

Autor: Donald R. Stanski, Keith T. Muir, David J. Hermann, Talmage D. Egan, Steven L. Shafer

Publikováno v: International Journal of Pharmaceutical Medicine. 15:11-19

The processed electroencephalogram (EEG) is a useful surrogate effect measure in estimating opioid potency and latency to peak effect. However, the relationship between EEG determined potency and clinical measures of potency is unclear. The aim of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4f9b2e444c25c75c78536b1ebb33538
https://doi.org/10.2165/00124363-200102000-00009

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Influence of arteriovenous sampling on remifentanil pharmacokinetics and pharmacodynamics

Autor: David J. Hermann, Keith T. Muir, Talmage D. Egan

Publikováno v: Clinical Pharmacology & Therapeutics. 65:511-518

Introduction Remifentanil is a new, short-acting, rapidly metabolized opioid. Because remifentanil is metabolized in blood and tissues by nonspecific esterases, there is a substantial difference between arterial and venous remifentanil concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd0af7861b7cf6c7db52299c79ef08
https://doi.org/10.1016/s0009-9236(99)70070-6

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The Comparative Pharmacodynamics of Remifentanil and Its Metabolite, GR90291, in a Rat Electroencephalographic Model

Autor: Josy M. Gubbens-Stibbe, Eugene H. Cox, M. W. E. Langemeijer, Meindert Danhof, Keith T. Muir

Publikováno v: Anesthesiology. 90:535-544

Background The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite, GR90291, in a rat electroencephalographic model. Methods Remifentanil and GR90291 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f312034b7d5409c5c5b63e63f4a81527
https://doi.org/10.1097/00000542-199902000-00030

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Evaluating a Possible Pharmacokinetic Interaction between Remifentanil and Esmolol in the Rat

Autor: Natalie D. Eddington, Zhongming Liang, John F. Hoke, Julian E. Moreton, Sam H. Haidar, Keith T. Muir

Publikováno v: Journal of Pharmaceutical Sciences. 86:1278-1282

Remifentanil (Ultiva) is a novel, ultra-short-acting opioid which has recently been approved for use as an analgesic during induction and maintenance of general anesthesia. Esmolol is a short-acting beta-blocker used during surgical procedures to red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6932cd157bed49967c858b8aa62425f4
https://doi.org/10.1021/js970079e

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Remifentanil and Pulmonary Extraction During and After Cardiac Anesthesia

Autor: Jan J. W. M. Stevens, Andrew J. T. Kirkham, Keith T. Muir, Anthony R. Doyle, David J. R. Duthie, Samir K. Gupta, Henry H. K. Baddoo

Publikováno v: Anesthesia & Analgesia. 84:740-744

We measured the apparent blood clearance and pulmonary extraction ratio of remifentanil in 10 adult patients undergoing elective myocardial revascularization for the first time with hypothermic cardiopulmonary bypass (CPB).Patients received continuou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8a35ea88e406dcb78476c753ea7c26
https://doi.org/10.1213/00000539-199704000-00007

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