Zobrazeno 1 - 10
of 369
pro vyhledávání: '"KEITH R. WALLEY"'
Autor:
Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin
Externí odkaz:
https://doaj.org/article/f5f9c595a1074237837d943ff4b74a9f
Autor:
Patrick R. Lawler, MD, MPH, Garen Manvelian, PhD, Alida Coppi, PhD, Amy Damask, PhD, Michael N. Cantor, MD, Manuel A. R. Ferreira, PhD, Charles Paulding, PhD, Nilanjana Banerjee, PhD, Dadong Li, PhD, Susan Jorgensen, MS, Richa Attre, PhD, David J. Carey, PhD, Kristi Krebs, PhD, Lili Milani, PhD, Kristian Hveem, MD, Jan K. Damås, PhD, Erik Solligård, PhD, Stefan Stender, MD, Anne Tybjærg-Hansen, MD, Børge G. Nordestgaard, MD, Tamara Hernandez-Beeftink, PhD, Tormod Rogne, MD, Carlos Flores, PhD, Jesús Villar, MD, Keith R. Walley, MD, Vincent X. Liu, MD, Alison E. Fohner, PhD, Luca A. Lotta, MD, Christos A. Kyratsous, PhD, Mark W. Sleeman, PhD, Michel Scemama, MD, Richard DelGizzi, MS, Robert Pordy, MD, Julie E. Horowitz, PhD, Aris Baras, MD, Greg S. Martin, MD, Philippe Gabriel Steg, MD, Gregory G. Schwartz, MD, Michael Szarek, PhD, Shaun G. Goodman, MD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 11, p e0997 (2023)
OBJECTIVES:. Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early inhibition of proprotein conve
Externí odkaz:
https://doaj.org/article/9668af2bf04b4033991c97345adef80d
Autor:
Mohammad M. Banoei, Lauralyn A. McIntyre, Duncan J. Stewart, Shirley H. J. Mei, David Courtman, Irene Watpool, John Granton, John Marshall, Claudia dos Santos, Keith R. Walley, Kenny Schlosser, Dean A. Fergusson, Brent W. Winston, on behalf of Canadian Critical Care Trials Group (CCCTG), on behalf of Canadian Critical Care Translational Biology Group (CCCTBG)
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1142 (2023)
Sepsis is the result of an uncontrolled host inflammatory response to infection that may lead to septic shock with multiorgan failure and a high mortality rate. There is an urgent need to improve early diagnosis and to find markers identifying those
Externí odkaz:
https://doaj.org/article/3455d13757b24114a6f29090a6d96d18
Autor:
Terry Lee, PhD, Alessandro Cau, BSc, Matthew Pellan Cheng, MD, Adeera Levin, MD, Todd C. Lee, MD, Donald C. Vinh, MD, Francois Lamontagne, MD, Joel Singer, PhD, Keith R. Walley, MD, Srinivas Murthy, MD, David Patrick, MD, Oleksa G. Rewa, MD, Brent W. Winston, MD, John Marshall, MD, John Boyd, MD, Karen Tran, MD, Andre C. Kalil, MD, Russell Mcculoh, MD, Robert Fowler, MD, James M. Luther, MD, James A. Russell, MD
Publikováno v:
CJC Open, Vol 3, Iss 7, Pp 965-975 (2021)
Background: Angiotensin receptor blockers (ARBs) and/or angiotensin-converting enzyme (ACE) inhibitors could alter mortality from coronavirus disease 2019 (COVID-19), but existing meta-analyses that combined crude and adjusted results may be confound
Externí odkaz:
https://doaj.org/article/5553bc00956f4f2b90b366257853dc68
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Lactate clearance is affected by hepatic function. However, it is unclear whether the association between hepatic dysfunction and lactate clearance can act as a prognostic marker of clinical outcomes in patients with septic shock. We aimed t
Externí odkaz:
https://doaj.org/article/7f98fea2fe824db2aace8bf0c8db4980
Autor:
Takashi Shimazui, Taka-aki Nakada, Keith R. Walley, Taku Oshima, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Kazuma Yamakawa, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Satoshi Fujimi, Satoshi Gando, on behalf of the JAAM FORECAST Group
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-9 (2020)
Abstract Background Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in el
Externí odkaz:
https://doaj.org/article/eb8bb58aa86b4e5bb69e1a4442d4e307
Autor:
Kelly Roveran Genga, Cody Lo, Mihai S. Cirstea, Fernando Sergio Leitao Filho, Keith R. Walley, James A. Russell, Adam Linder, Gordon A. Francis, John H. Boyd
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 257-264 (2018)
Background: Reduced activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) has been associated with decreased short-term death in patients with septic shock. Whether PCSK9 genotype influences long-term outcomes in sepsis survivors is unkno
Externí odkaz:
https://doaj.org/article/3cb285c9e71f411e929da8ca5a85eac3
Publikováno v:
Journal of Intensive Care, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Purpose It is not clear whether vasopressin versus norepinephrine changed mortality in clinical practice in the Vasopressin and Septic Shock Trial (VASST) coordinating center hospital after VASST was published. We tested the hypothesis that
Externí odkaz:
https://doaj.org/article/aac081c12a514c1f974cd8c3ec6e49f3
Autor:
Beth A. Payne, Helen Ryan, Jeffrey Bone, Laura A. Magee, Alice B. Aarvold, J. Mark Ansermino, Zulfiqar A. Bhutta, Mary Bowen, J. Guilherme Cecatti, Cynthia Chazotte, Tim Crozier, Anne-Cornélie J. M. de Pont, Oktay Demirkiran, Tao Duan, Marlot Kallen, Wessel Ganzevoort, Michael Geary, Dena Goffman, Jennifer A. Hutcheon, K. S. Joseph, Stephen E. Lapinsky, Isam Lataifeh, Jing Li, Sarka Liskonova, Emily M. Hamel, Fionnuala M. McAuliffe, Colm O’Herlihy, Ben W. J. Mol, P. Gareth R. Seaward, Ramzy Tadros, Turkan Togal, Rahat Qureshi, U. Vivian Ukah, Daniela Vasquez, Euan Wallace, Paul Yong, Vivian Zhou, Keith R. Walley, Peter von Dadelszen, the CIPHER Group
Publikováno v:
Critical Care, Vol 22, Iss 1, Pp 1-13 (2018)
Abstract Background Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations is contentious. The ai
Externí odkaz:
https://doaj.org/article/ef1e6ddbaa5d46a78fc93832fcc42ebd
Autor:
Mary Thompson, Shirley H.J. Mei, Dianna Wolfe, Josée Champagne, Dean Fergusson, Duncan J. Stewart, Katrina J. Sullivan, Emily Doxtator, Manoj Lalu, Shane W. English, John Granton, Brian Hutton, John Marshall, Alies Maybee, Keith R. Walley, Claudia Dos Santos, Brent Winston, Lauralyn McIntyre
Publikováno v:
EClinicalMedicine, Vol 19, Iss , Pp - (2020)
Background: Characterization of the mesenchymal stromal cell (MSC) safety profile is important as this novel therapy continues to be evaluated in clinical trials for various inflammatory conditions. Due to an increase in published randomized controll
Externí odkaz:
https://doaj.org/article/2856876ef0534afc924b326b38252675