Zobrazeno 1 - 10
of 67
pro vyhledávání: '"KEITARO SATOH"'
Autor:
Hajime Sato, Keitaro Satoh, Kazunori Nozaki, Misato Yugawa, Takafumi Kato, Hiroki Toyoda, Ayano Katagiri, Naoto Suda, Kazunori Adachi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms, and it is associated with several prodromal non-motor symptoms, including an impaired sense of smell, taste and touch. We previously reported that bitter tast
Externí odkaz:
https://doaj.org/article/d0a9544948c14428a6a947205cf76fd7
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17220 (2023)
Cdc42 is a small GTPase essential for the cell cycle, morphogenesis, and cell adhesion, and it is involved in the polarity of epithelial cells. However, the functional roles of Cdc42 in exocrine glands, such as the maintenance of acini and water secr
Externí odkaz:
https://doaj.org/article/ca52cfa019a64f678421c1cf97cb058d
Autor:
Motoshi Ouchi, Asuka Morita, Keitaro Satoh, Shunsuke Kobayashi, Misao Terada, Hiroe Kon, Keitaro Hayashi, Tatsuya Suzuki, Kenzo Oba, Hitoshi Sugihara, Masahiro Yasutake, Naohiko Anzai, Tomoe Fujita
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 66-72 (2022)
Organ bath experiments are conventionally used to investigate the physiological actions and effects of hormones and drugs on organ responses. We developed an experimental method to reproduce insulin secretion from isolated rat pancreas preparations,
Externí odkaz:
https://doaj.org/article/1b2bdd34a7454a31b8619adc8ad7214a
Autor:
Yuta Ohno, Tomohiro Yako, Keitaro Satoh, Haruna Nagase, Akiko Shitara, Hideaki Hara, Masanori Kashimata
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 1, Pp 20-26 (2022)
Early detection of such retinal diseases as glaucoma and age-related macular degeneration (AMD) is important to prevent blindness. There have been reports of changes in some components in the tears of glaucoma and AMD patients, suggesting tears' pote
Externí odkaz:
https://doaj.org/article/5c4d8c0ecab14f8897f2a1e8fc6f982b
Autor:
Aruna Chhikara, Praveen K. Roayapalley, Hiroshi Sakagami, Shigeru Amano, Keitaro Satoh, Yoshihiro Uesawa, Umashankar Das, Swagatika Das, Edgar A. Borrego, Cristina D. Guerena, Clare R. Hernandez, Renato J. Aguilera, Jonathan R. Dimmock
Publikováno v:
Molecules, Vol 27, Iss 19, p 6718 (2022)
Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones 2a–f and 3a–e were designed as candidate antineoplastic agents. These compounds display potent cytotoxicity towards two colon cancers, as well as several oral squamous cell carc
Externí odkaz:
https://doaj.org/article/2a31bd5df66d4cda8c251e729ecf8583
Autor:
Mohammad Hossain, Praveen K. Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Kenjiro Bandow, Umashankar Das, Jonathan R. Dimmock
Publikováno v:
Medicines, Vol 9, Iss 6, p 35 (2022)
A series of 3,5-bis(benzylidene)-1-dichloroacetyl-4-piperidones 1a–l was evaluated against Ca9-22, HSC-2, HSC-3, and HSC-4 squamous cell carcinomas. Virtually all of the compounds displayed potent cytotoxicity, with 83% of the CC50 values being sub
Externí odkaz:
https://doaj.org/article/e1392a226b3e438e9c17385d828908b1
Autor:
Kotone Naitoh, Yuta Orihara, Hiroshi Sakagami, Takumi Miura, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Yosuke Iijima, Kota Kurosaki, Yoshihiro Uesawa, Masashi Hashimoto, Hidetsugu Wakabayashi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2601 (2022)
Background: Very few papers covering the anticancer activity of azulenes have been reported, as compared with those of antibacterial and anti-inflammatory activity. This led us to investigate the antitumor potential of fifteen 4,6,8-trimethyl azulene
Externí odkaz:
https://doaj.org/article/eec2e00e8ca7495eae411ecb55b5a784
Autor:
Praveen K. Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Renato J. Aguilera, Karla G. Cano Hernandez, Austre Y. Schiaffino Bustamante, Stephen G. Dimmock, Rajendra K. Sharma, Umashankar Das, Jonathan R. Dimmock
Publikováno v:
Medicines, Vol 8, Iss 12, p 78 (2021)
A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In general, the compounds are highly toxic to human gingival carcinoma (Ca9-22), human squamous carcinoma-2 (HSC-2) and human squamous carcinoma-4 (HSC
Externí odkaz:
https://doaj.org/article/198a39eb92f24173b32bdf749d37a50d
Autor:
Hiroshi Sakagami, Toshiko Furukawa, Keitaro Satoh, Shigeru Amano, Yosuke Iijima, Takuro Koshikawa, Daisuke Asai, Kunihiko Fukuchi, Hiromu Takemura, Taisei Kanamoto, Satoshi Yokose
Publikováno v:
Medicines, Vol 8, Iss 7, p 33 (2021)
Background: Pyoktanin blue (PB) is used for staining tissues and cells, and it is applied in photodynamic therapy due to its potent bactericidal activity. However, clinical application of PB as an antiviral and antitumor agent has been limited due to
Externí odkaz:
https://doaj.org/article/9447aea798784f2bafe5e68138571ce5
Autor:
Hiroshi Sugiya, Keitaro Satoh
Publikováno v:
Japanese Dental Science Review, Vol 45, Iss 2, Pp 121-126 (2009)
It is well known that β-adrenergic receptor activation in parotid acinar cells results in increased intracellular cAMP levels, and consequently induces exocytotic amylase release. However, protein kinase C (PKC) has also been considered to contribut
Externí odkaz:
https://doaj.org/article/f0c179c5f0ba484cb94b4dd301a57d5c